Longitudinal change in cardiac structure and function following acute coronary syndrome according to culprit coronary artery lesion
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Longitudinal change in cardiac structure and function following acute coronary syndrome according to culprit coronary artery lesion. / Ravnkilde, Kirstine; Skaarup, Kristoffer Grundtvig; Grove, Gabriela Lladó; Modin, Daniel; Nielsen, Anne Bjerg; Falsing, Mathilde Musoni; Iversen, Allan Zeeberg; Pedersen, Sune; Fritz-Hansen, Thomas; Galatius, Søren; Shah, Amil; Biering-Sørensen, Tor.
In: International Journal of Cardiovascular Imaging, Vol. 38, No. 5, 2022, p. 1029–1036.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Longitudinal change in cardiac structure and function following acute coronary syndrome according to culprit coronary artery lesion
AU - Ravnkilde, Kirstine
AU - Skaarup, Kristoffer Grundtvig
AU - Grove, Gabriela Lladó
AU - Modin, Daniel
AU - Nielsen, Anne Bjerg
AU - Falsing, Mathilde Musoni
AU - Iversen, Allan Zeeberg
AU - Pedersen, Sune
AU - Fritz-Hansen, Thomas
AU - Galatius, Søren
AU - Shah, Amil
AU - Biering-Sørensen, Tor
PY - 2022
Y1 - 2022
N2 - Acute coronary syndrome (ACS) may lead to adverse remodelling and impaired cardiac function. Limited data exists on the effect of culprit coronary artery lesion site and impact on longitudinal cardiac remodelling. The present study included a total of 299 patients suffering from ACS treated with percutaneous coronary intervention (PCI). All patients had two echocardiographic examinations. The first echocardiography was median 2(IQR: 1;3) days following PCI, while the follow-up echocardiography (FUE) was median 257(IQR: 96;942) days following the first. Patients were grouped based on coronary artery PCI location; left anterior descending artery (LAD), right coronary artery (RCA) or circumflex artery (Cx). Patients with multiple lesions were excluded. Mean age was 63 +/- 11 years and 77% were male. At FUE, mean left ventricular ejection fraction was 42 +/- 9% and global longitudinal strain (GLS) was - 13 +/- 4%. PCI treatment was allocated as 168 LAD lesions, 95 RCA lesions, and 36 Cx lesions. Linear regression analysis showed that patients with a LAD lesion displayed worsening in E/A (mean increment = 0.05, beta = - 0.196, p = 0.001) and a larger increase in LVEDV (mean increment = 33.18 mL, beta = 0.135, p = 0.012). Meanwhile patients with Cx lesion were significantly associated with a larger decrease in E/e ' (mean increment = 2.6, beta = - 0.120, p = 0.028). Patients with Cx lesion were observed to have elevated E/e ' at baseline, which normalized at FUE. The present study suggests that culprit coronary artery lesion has a differential impact on myocardial remodelling. This information may potentially aid in understanding the pathophysiological differences in cardiac structure and function amongst patients with ACS.
AB - Acute coronary syndrome (ACS) may lead to adverse remodelling and impaired cardiac function. Limited data exists on the effect of culprit coronary artery lesion site and impact on longitudinal cardiac remodelling. The present study included a total of 299 patients suffering from ACS treated with percutaneous coronary intervention (PCI). All patients had two echocardiographic examinations. The first echocardiography was median 2(IQR: 1;3) days following PCI, while the follow-up echocardiography (FUE) was median 257(IQR: 96;942) days following the first. Patients were grouped based on coronary artery PCI location; left anterior descending artery (LAD), right coronary artery (RCA) or circumflex artery (Cx). Patients with multiple lesions were excluded. Mean age was 63 +/- 11 years and 77% were male. At FUE, mean left ventricular ejection fraction was 42 +/- 9% and global longitudinal strain (GLS) was - 13 +/- 4%. PCI treatment was allocated as 168 LAD lesions, 95 RCA lesions, and 36 Cx lesions. Linear regression analysis showed that patients with a LAD lesion displayed worsening in E/A (mean increment = 0.05, beta = - 0.196, p = 0.001) and a larger increase in LVEDV (mean increment = 33.18 mL, beta = 0.135, p = 0.012). Meanwhile patients with Cx lesion were significantly associated with a larger decrease in E/e ' (mean increment = 2.6, beta = - 0.120, p = 0.028). Patients with Cx lesion were observed to have elevated E/e ' at baseline, which normalized at FUE. The present study suggests that culprit coronary artery lesion has a differential impact on myocardial remodelling. This information may potentially aid in understanding the pathophysiological differences in cardiac structure and function amongst patients with ACS.
KW - Echocardiography
KW - Cardiac remodelling
KW - Follow-up echocardiography
KW - Acute coronary syndrome
KW - MYOCARDIAL-INFARCTION
KW - EJECTION FRACTION
KW - LOCATION
KW - ELEVATION
U2 - 10.1007/s10554-021-02478-8
DO - 10.1007/s10554-021-02478-8
M3 - Journal article
C2 - 34855043
VL - 38
SP - 1029
EP - 1036
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
SN - 1569-5794
IS - 5
ER -
ID: 286843762