Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls

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Standard

Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls. / Yabe, D; Kuroe, A; Lee, S; Watanabe, K; Hyo, T; Hishizawa, M; Kurose, T; Deacon, Carolyn F.; Holst, Jens Juul; Hirano, T; Inagaki, N; Seino, Y.

In: Journal of Diabetes Investigation, Vol. 1, No. 1/2, 01.2010, p. 56-59.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Yabe, D, Kuroe, A, Lee, S, Watanabe, K, Hyo, T, Hishizawa, M, Kurose, T, Deacon, CF, Holst, JJ, Hirano, T, Inagaki, N & Seino, Y 2010, 'Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls', Journal of Diabetes Investigation, vol. 1, no. 1/2, pp. 56-59. https://doi.org/10.1111/j.2040-1124.2010.00010.x

APA

Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, C. F., Holst, J. J., Hirano, T., Inagaki, N., & Seino, Y. (2010). Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls. Journal of Diabetes Investigation, 1(1/2), 56-59. https://doi.org/10.1111/j.2040-1124.2010.00010.x

Vancouver

Yabe D, Kuroe A, Lee S, Watanabe K, Hyo T, Hishizawa M et al. Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls. Journal of Diabetes Investigation. 2010 Jan;1(1/2):56-59. https://doi.org/10.1111/j.2040-1124.2010.00010.x

Author

Yabe, D ; Kuroe, A ; Lee, S ; Watanabe, K ; Hyo, T ; Hishizawa, M ; Kurose, T ; Deacon, Carolyn F. ; Holst, Jens Juul ; Hirano, T ; Inagaki, N ; Seino, Y. / Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls. In: Journal of Diabetes Investigation. 2010 ; Vol. 1, No. 1/2. pp. 56-59.

Bibtex

@article{ba860bfb88dc49ac80b1882e87001038,
title = "Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls",
abstract = "Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30–40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese",
author = "D Yabe and A Kuroe and S Lee and K Watanabe and T Hyo and M Hishizawa and T Kurose and Deacon, {Carolyn F.} and Holst, {Jens Juul} and T Hirano and N Inagaki and Y Seino",
year = "2010",
month = jan,
doi = "10.1111/j.2040-1124.2010.00010.x",
language = "English",
volume = "1",
pages = "56--59",
journal = "Journal of Diabetes Investigation",
number = "1/2",

}

RIS

TY - JOUR

T1 - Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls

AU - Yabe, D

AU - Kuroe, A

AU - Lee, S

AU - Watanabe, K

AU - Hyo, T

AU - Hishizawa, M

AU - Kurose, T

AU - Deacon, Carolyn F.

AU - Holst, Jens Juul

AU - Hirano, T

AU - Inagaki, N

AU - Seino, Y

PY - 2010/1

Y1 - 2010/1

N2 - Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30–40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese

AB - Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30–40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese

U2 - 10.1111/j.2040-1124.2010.00010.x

DO - 10.1111/j.2040-1124.2010.00010.x

M3 - Journal article

C2 - 24843409

VL - 1

SP - 56

EP - 59

JO - Journal of Diabetes Investigation

JF - Journal of Diabetes Investigation

IS - 1/2

ER -

ID: 33724701