Left atrial functional measurements’ utility in predicting long-term risk of atrial fibrillation after isolated CABG
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Left atrial functional measurements’ utility in predicting long-term risk of atrial fibrillation after isolated CABG. / Dyhr, Mikkel Ravn; Olsen, Flemming Javier; Lindberg, Søren; Modin, Daniel; Fritz-Hansen, Thomas; Pedersen, Sune; Iversen, Allan; Galatius, Søren; Jespersen, Thomas; Møgelvang, Rasmus; Biering-Sørensen, Tor.
In: Echocardiography, Vol. 40, No. 7, 2023, p. 695-702.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Left atrial functional measurements’ utility in predicting long-term risk of atrial fibrillation after isolated CABG
AU - Dyhr, Mikkel Ravn
AU - Olsen, Flemming Javier
AU - Lindberg, Søren
AU - Modin, Daniel
AU - Fritz-Hansen, Thomas
AU - Pedersen, Sune
AU - Iversen, Allan
AU - Galatius, Søren
AU - Jespersen, Thomas
AU - Møgelvang, Rasmus
AU - Biering-Sørensen, Tor
N1 - Publisher Copyright: © 2023 The Authors. Echocardiography published by Wiley Periodicals LLC.
PY - 2023
Y1 - 2023
N2 - Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia following coronary artery bypass grafting (CABG). We hypothesized that measures of left atrial (LA) function would be useful in predicting AF in patients undergoing CABG. Methods and results: In the study, 611 patients were included after CABG. All patients had echocardiograms performed preoperatively and LA functional measurements were assessed. These measurements were LA maximum volume index (LAVmax), LA minimum volume index (LAVmin) and LA emptying fraction (LAEF). The endpoint was AF occurring >14 days after surgery. During the follow-up period of a median of 3.7 years, 52 (9%) developed AF. The mean age was 67 years, 84% were male and the average left ventricle ejection fraction was 50%. Patients who developed AF had a lower CCS class and lower LAEF (40 vs. 45%), otherwise no clinical differences were observed between outcome groups. No functional LA measurements were significant predictors of AF in the whole CABG population. However, in patients with normal-sized LA (n = 532, events: 49), both LAEF and LAVmin were univariable predictors of AF. When the functional measurements were adjusted for the CHADS2 score, both LAVmin (HR = 1.07 [1.01-1.13], p =.014) and LAEF (HR: 1.02 [1.00-1.03], p =.023), remained significant predictors. Conclusion: No echocardiographic measurements were significant predictors of AF after CABG. In patients with a normal LA size, LAVmin as well as LAEF were significant predictors of AF.
AB - Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia following coronary artery bypass grafting (CABG). We hypothesized that measures of left atrial (LA) function would be useful in predicting AF in patients undergoing CABG. Methods and results: In the study, 611 patients were included after CABG. All patients had echocardiograms performed preoperatively and LA functional measurements were assessed. These measurements were LA maximum volume index (LAVmax), LA minimum volume index (LAVmin) and LA emptying fraction (LAEF). The endpoint was AF occurring >14 days after surgery. During the follow-up period of a median of 3.7 years, 52 (9%) developed AF. The mean age was 67 years, 84% were male and the average left ventricle ejection fraction was 50%. Patients who developed AF had a lower CCS class and lower LAEF (40 vs. 45%), otherwise no clinical differences were observed between outcome groups. No functional LA measurements were significant predictors of AF in the whole CABG population. However, in patients with normal-sized LA (n = 532, events: 49), both LAEF and LAVmin were univariable predictors of AF. When the functional measurements were adjusted for the CHADS2 score, both LAVmin (HR = 1.07 [1.01-1.13], p =.014) and LAEF (HR: 1.02 [1.00-1.03], p =.023), remained significant predictors. Conclusion: No echocardiographic measurements were significant predictors of AF after CABG. In patients with a normal LA size, LAVmin as well as LAEF were significant predictors of AF.
KW - atrial fibrillation
KW - cardiac surgery
KW - echocardiography
KW - left atrium
U2 - 10.1111/echo.15636
DO - 10.1111/echo.15636
M3 - Journal article
C2 - 37335308
AN - SCOPUS:85162186038
VL - 40
SP - 695
EP - 702
JO - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques
JF - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques
SN - 0742-2822
IS - 7
ER -
ID: 358432199