Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development. / Petersen, Yvette M; Hartmann, Bolette; Holst, Jens Juul; Le Huerou-Luron, Isabelle; Bjørnvad, Charlotte R; Sangild, Per T.

In: Journal of Nutrition, Vol. 133, No. 6, 06.2003, p. 1781-6.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Petersen, YM, Hartmann, B, Holst, JJ, Le Huerou-Luron, I, Bjørnvad, CR & Sangild, PT 2003, 'Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development', Journal of Nutrition, vol. 133, no. 6, pp. 1781-6.

APA

Petersen, Y. M., Hartmann, B., Holst, J. J., Le Huerou-Luron, I., Bjørnvad, C. R., & Sangild, P. T. (2003). Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development. Journal of Nutrition, 133(6), 1781-6.

Vancouver

Petersen YM, Hartmann B, Holst JJ, Le Huerou-Luron I, Bjørnvad CR, Sangild PT. Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development. Journal of Nutrition. 2003 Jun;133(6):1781-6.

Author

Petersen, Yvette M ; Hartmann, Bolette ; Holst, Jens Juul ; Le Huerou-Luron, Isabelle ; Bjørnvad, Charlotte R ; Sangild, Per T. / Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development. In: Journal of Nutrition. 2003 ; Vol. 133, No. 6. pp. 1781-6.

Bibtex

@article{d5ff8de809ff48a1ac0744bedef9c049,
title = "Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development",
abstract = "Glucagon-like peptide 2 (GLP-2) may mediate in part the rapid growth effects of luminal nutrients in the small intestine of newborns. The objectives of this study were to determine plasma GLP-2 concentrations and small intestinal GLP-2 receptor (GLP-2R) mRNA abundance (measured by reverse transcription polymerase chain reaction) during pre- and postnatal development and the relationship between these variables and small intestinal growth in enterally and parenterally fed fetal and newborn pigs (premature and term-delivered, 92 and 100{\%} gestation, respectively). Plasma GLP-2 concentrations increased before birth, peaked in suckling 1-d-old pigs (87 +/- 14 pmol/L, P < 0.05), decreased with weaning-related anorexia (34 +/- 5 pmol/L, P < 0.05) and increased when normal food intake resumed (81 +/- 9 pmol/L, P < 0.05). Plasma GLP-2 concentrations were increased 1 d after enteral infusion of colostrum in fetal pigs at 92{\%} gestation compared with untreated controls (59 +/- 11 vs. 7 +/- 2 pmol/L, P < 0.05). In newborn pigs, plasma GLP-2 was increased 2-6 d after the enteral administration of a milk diet, compared with the parenteral infusion of elemental nutrients, but the time course of the response was delayed in premature newborn pigs. Small intestinal GLP-2R mRNA abundance was highest at birth and decreased with enteral food intake in fetal, suckling and weaned pigs (P < 0.05). In contrast, enteral feeding increased (P < 0.05) relative small intestinal weight and/or villous heights in these pigs. We conclude that the introduction of enteral feeding transiently increases plasma GLP-2 concentrations and decreases small intestinal GLP-2R mRNA levels during pig development. GLP-2 may play a role in the growth of the small intestine around birth and weaning via a response to enteral nutrition.",
keywords = "Aging, Animals, Animals, Newborn, Enteral Nutrition, Fetus, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Intestine, Small, Parenteral Nutrition, Parturition, Peptides, RNA, Messenger, Receptors, Glucagon, Swine",
author = "Petersen, {Yvette M} and Bolette Hartmann and Holst, {Jens Juul} and {Le Huerou-Luron}, Isabelle and Bj{\o}rnvad, {Charlotte R} and Sangild, {Per T}",
year = "2003",
month = "6",
language = "English",
volume = "133",
pages = "1781--6",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "6",

}

RIS

TY - JOUR

T1 - Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development

AU - Petersen, Yvette M

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Le Huerou-Luron, Isabelle

AU - Bjørnvad, Charlotte R

AU - Sangild, Per T

PY - 2003/6

Y1 - 2003/6

N2 - Glucagon-like peptide 2 (GLP-2) may mediate in part the rapid growth effects of luminal nutrients in the small intestine of newborns. The objectives of this study were to determine plasma GLP-2 concentrations and small intestinal GLP-2 receptor (GLP-2R) mRNA abundance (measured by reverse transcription polymerase chain reaction) during pre- and postnatal development and the relationship between these variables and small intestinal growth in enterally and parenterally fed fetal and newborn pigs (premature and term-delivered, 92 and 100% gestation, respectively). Plasma GLP-2 concentrations increased before birth, peaked in suckling 1-d-old pigs (87 +/- 14 pmol/L, P < 0.05), decreased with weaning-related anorexia (34 +/- 5 pmol/L, P < 0.05) and increased when normal food intake resumed (81 +/- 9 pmol/L, P < 0.05). Plasma GLP-2 concentrations were increased 1 d after enteral infusion of colostrum in fetal pigs at 92% gestation compared with untreated controls (59 +/- 11 vs. 7 +/- 2 pmol/L, P < 0.05). In newborn pigs, plasma GLP-2 was increased 2-6 d after the enteral administration of a milk diet, compared with the parenteral infusion of elemental nutrients, but the time course of the response was delayed in premature newborn pigs. Small intestinal GLP-2R mRNA abundance was highest at birth and decreased with enteral food intake in fetal, suckling and weaned pigs (P < 0.05). In contrast, enteral feeding increased (P < 0.05) relative small intestinal weight and/or villous heights in these pigs. We conclude that the introduction of enteral feeding transiently increases plasma GLP-2 concentrations and decreases small intestinal GLP-2R mRNA levels during pig development. GLP-2 may play a role in the growth of the small intestine around birth and weaning via a response to enteral nutrition.

AB - Glucagon-like peptide 2 (GLP-2) may mediate in part the rapid growth effects of luminal nutrients in the small intestine of newborns. The objectives of this study were to determine plasma GLP-2 concentrations and small intestinal GLP-2 receptor (GLP-2R) mRNA abundance (measured by reverse transcription polymerase chain reaction) during pre- and postnatal development and the relationship between these variables and small intestinal growth in enterally and parenterally fed fetal and newborn pigs (premature and term-delivered, 92 and 100% gestation, respectively). Plasma GLP-2 concentrations increased before birth, peaked in suckling 1-d-old pigs (87 +/- 14 pmol/L, P < 0.05), decreased with weaning-related anorexia (34 +/- 5 pmol/L, P < 0.05) and increased when normal food intake resumed (81 +/- 9 pmol/L, P < 0.05). Plasma GLP-2 concentrations were increased 1 d after enteral infusion of colostrum in fetal pigs at 92% gestation compared with untreated controls (59 +/- 11 vs. 7 +/- 2 pmol/L, P < 0.05). In newborn pigs, plasma GLP-2 was increased 2-6 d after the enteral administration of a milk diet, compared with the parenteral infusion of elemental nutrients, but the time course of the response was delayed in premature newborn pigs. Small intestinal GLP-2R mRNA abundance was highest at birth and decreased with enteral food intake in fetal, suckling and weaned pigs (P < 0.05). In contrast, enteral feeding increased (P < 0.05) relative small intestinal weight and/or villous heights in these pigs. We conclude that the introduction of enteral feeding transiently increases plasma GLP-2 concentrations and decreases small intestinal GLP-2R mRNA levels during pig development. GLP-2 may play a role in the growth of the small intestine around birth and weaning via a response to enteral nutrition.

KW - Aging

KW - Animals

KW - Animals, Newborn

KW - Enteral Nutrition

KW - Fetus

KW - Glucagon-Like Peptide 2

KW - Glucagon-Like Peptides

KW - Intestine, Small

KW - Parenteral Nutrition

KW - Parturition

KW - Peptides

KW - RNA, Messenger

KW - Receptors, Glucagon

KW - Swine

M3 - Journal article

C2 - 12771317

VL - 133

SP - 1781

EP - 1786

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 6

ER -

ID: 132056110