Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling

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Standard

Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling. / Prats Gavalda, Clara; Gomez-Cabello, Alba; Vigelsø Hansen, Andreas.

In: Experimental Physiology, Vol. 96, No. 4, 2011, p. 385-390.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Prats Gavalda, C, Gomez-Cabello, A & Vigelsø Hansen, A 2011, 'Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling', Experimental Physiology, vol. 96, no. 4, pp. 385-390. https://doi.org/10.1113/expphysiol.2010.052860

APA

Prats Gavalda, C., Gomez-Cabello, A., & Vigelsø Hansen, A. (2011). Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling. Experimental Physiology, 96(4), 385-390. https://doi.org/10.1113/expphysiol.2010.052860

Vancouver

Prats Gavalda C, Gomez-Cabello A, Vigelsø Hansen A. Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling. Experimental Physiology. 2011;96(4):385-390. https://doi.org/10.1113/expphysiol.2010.052860

Author

Prats Gavalda, Clara ; Gomez-Cabello, Alba ; Vigelsø Hansen, Andreas. / Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling. In: Experimental Physiology. 2011 ; Vol. 96, No. 4. pp. 385-390.

Bibtex

@article{da7f6a8d4f7345c282009997767508b0,
title = "Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling",
abstract = "The interest in skeletal muscle metabolism and insulin signalling has increased exponentially in recent years as a consequence of their role in the development of type 2 diabetes mellitus. Despite this, the exact mechanisms involved in the regulation of skeletal muscle glycogen metabolism and insulin signalling transduction remain elusive. We believe that one of the reasons is that the role of intracellular compartmentalization as a regulator of metabolic pathways and signalling transduction has been rather ignored. This paper briefly reviews the literature to discuss the role of intracellular compartmentalization in the regulation of skeletal muscle glycogen metabolism and insulin signalling. As a result, a hypothetical regulatory mechanism is proposed by which cells could direct glycogen resynthesis towards different pools of glycogen particles depending on the metabolic needs. Furthermore, we discuss the role of skeletal muscle transverse tubules as potential modulators of tissue insulin responsiveness. ",
author = "{Prats Gavalda}, Clara and Alba Gomez-Cabello and {Vigels{\o} Hansen}, Andreas",
year = "2011",
doi = "10.1113/expphysiol.2010.052860",
language = "English",
volume = "96",
pages = "385--390",
journal = "Experimental Physiology",
issn = "0958-0670",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling

AU - Prats Gavalda, Clara

AU - Gomez-Cabello, Alba

AU - Vigelsø Hansen, Andreas

PY - 2011

Y1 - 2011

N2 - The interest in skeletal muscle metabolism and insulin signalling has increased exponentially in recent years as a consequence of their role in the development of type 2 diabetes mellitus. Despite this, the exact mechanisms involved in the regulation of skeletal muscle glycogen metabolism and insulin signalling transduction remain elusive. We believe that one of the reasons is that the role of intracellular compartmentalization as a regulator of metabolic pathways and signalling transduction has been rather ignored. This paper briefly reviews the literature to discuss the role of intracellular compartmentalization in the regulation of skeletal muscle glycogen metabolism and insulin signalling. As a result, a hypothetical regulatory mechanism is proposed by which cells could direct glycogen resynthesis towards different pools of glycogen particles depending on the metabolic needs. Furthermore, we discuss the role of skeletal muscle transverse tubules as potential modulators of tissue insulin responsiveness.

AB - The interest in skeletal muscle metabolism and insulin signalling has increased exponentially in recent years as a consequence of their role in the development of type 2 diabetes mellitus. Despite this, the exact mechanisms involved in the regulation of skeletal muscle glycogen metabolism and insulin signalling transduction remain elusive. We believe that one of the reasons is that the role of intracellular compartmentalization as a regulator of metabolic pathways and signalling transduction has been rather ignored. This paper briefly reviews the literature to discuss the role of intracellular compartmentalization in the regulation of skeletal muscle glycogen metabolism and insulin signalling. As a result, a hypothetical regulatory mechanism is proposed by which cells could direct glycogen resynthesis towards different pools of glycogen particles depending on the metabolic needs. Furthermore, we discuss the role of skeletal muscle transverse tubules as potential modulators of tissue insulin responsiveness.

U2 - 10.1113/expphysiol.2010.052860

DO - 10.1113/expphysiol.2010.052860

M3 - Journal article

VL - 96

SP - 385

EP - 390

JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

IS - 4

ER -

ID: 33811531