Interleukin-6: possible biological roles during exercise
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Interleukin-6 : possible biological roles during exercise. / Reihmane, Dace; Dela, Flemming.
In: European Journal of Sport Science, Vol. 14, No. 3, 2014, p. 242-50.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Interleukin-6
T2 - possible biological roles during exercise
AU - Reihmane, Dace
AU - Dela, Flemming
PY - 2014
Y1 - 2014
N2 - Interleukin-6 (IL-6) is a multifunctional cytokine that exerts its modulatory effects on cells that express membrane bound IL-6 receptors; however, IL-6 in a complex with soluble IL-6R can bind to any cell that express glycoprotein 130 (gp130). Thus, all cell types may respond to the pro- as well as anti-inflammatory properties of IL-6. Since the first report of acute exercise-induced increase in plasma IL-6 in the early 1990s, scientists have tried to elucidate the factors that influence the magnitude of change of plasma IL-6, as well as the possible biological roles of this cytokine. Evidence suggests that exercise intensity and duration as well as the form of contraction (e.g., eccentric or concentric) and muscle damage all influence IL-6 response to acute exercise. However, data on training status and performance on plasma IL-6 concentration changes during exercise are more inconclusive, as discussed in this review. In the last decade, most of the studies have focused on IL-6 as an 'energy sensor' possibly secreted by skeletal muscle that activates glycogenolysis in the liver and lipolysis in fat tissue in order to provide muscle with the growing energy demands during exercise.
AB - Interleukin-6 (IL-6) is a multifunctional cytokine that exerts its modulatory effects on cells that express membrane bound IL-6 receptors; however, IL-6 in a complex with soluble IL-6R can bind to any cell that express glycoprotein 130 (gp130). Thus, all cell types may respond to the pro- as well as anti-inflammatory properties of IL-6. Since the first report of acute exercise-induced increase in plasma IL-6 in the early 1990s, scientists have tried to elucidate the factors that influence the magnitude of change of plasma IL-6, as well as the possible biological roles of this cytokine. Evidence suggests that exercise intensity and duration as well as the form of contraction (e.g., eccentric or concentric) and muscle damage all influence IL-6 response to acute exercise. However, data on training status and performance on plasma IL-6 concentration changes during exercise are more inconclusive, as discussed in this review. In the last decade, most of the studies have focused on IL-6 as an 'energy sensor' possibly secreted by skeletal muscle that activates glycogenolysis in the liver and lipolysis in fat tissue in order to provide muscle with the growing energy demands during exercise.
U2 - 10.1080/17461391.2013.776640
DO - 10.1080/17461391.2013.776640
M3 - Review
C2 - 24655147
VL - 14
SP - 242
EP - 250
JO - European Journal of Sport Science
JF - European Journal of Sport Science
SN - 1746-1391
IS - 3
ER -
ID: 110099142