Influence of maximal fat oxidation on long-term weight loss maintenance in humans

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Influence of maximal fat oxidation on long-term weight loss maintenance in humans. / Dandanell, Sune; Husted, Karina; Amdisen, Signe; Vigelso, Andreas; Dela, Flemming; Larsen, Steen; Helge, Jorn Wulff.

In: Journal of Applied Physiology, Vol. 123, No. 1, 07.2017, p. 267-274.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Dandanell, S, Husted, K, Amdisen, S, Vigelso, A, Dela, F, Larsen, S & Helge, JW 2017, 'Influence of maximal fat oxidation on long-term weight loss maintenance in humans', Journal of Applied Physiology, vol. 123, no. 1, pp. 267-274. https://doi.org/10.1152/japplphysiol.00270.2017

APA

Dandanell, S., Husted, K., Amdisen, S., Vigelso, A., Dela, F., Larsen, S., & Helge, J. W. (2017). Influence of maximal fat oxidation on long-term weight loss maintenance in humans. Journal of Applied Physiology, 123(1), 267-274. https://doi.org/10.1152/japplphysiol.00270.2017

Vancouver

Dandanell S, Husted K, Amdisen S, Vigelso A, Dela F, Larsen S et al. Influence of maximal fat oxidation on long-term weight loss maintenance in humans. Journal of Applied Physiology. 2017 Jul;123(1):267-274. https://doi.org/10.1152/japplphysiol.00270.2017

Author

Dandanell, Sune ; Husted, Karina ; Amdisen, Signe ; Vigelso, Andreas ; Dela, Flemming ; Larsen, Steen ; Helge, Jorn Wulff. / Influence of maximal fat oxidation on long-term weight loss maintenance in humans. In: Journal of Applied Physiology. 2017 ; Vol. 123, No. 1. pp. 267-274.

Bibtex

@article{1c87009a522346bc909ceef7adaf46bc,
title = "Influence of maximal fat oxidation on long-term weight loss maintenance in humans",
abstract = "Impaired maximal fat oxidation has been linked to obesity and weight regain after weight loss. The aim was to investigate the relationship between maximal fat oxidation (MFO) and long-term weight loss maintenance. Eighty subjects [means (SD): age, 36(13) yrs; BMI, 38(1) kg/m2] were recruited from a total of 2,420 former participants of an 11- to 12-wk lifestyle intervention. Three groups were established based on percent weight loss at follow-up [5.3(3.3) yr]: clinical weight loss maintenance (CWL), >10{\%} weight loss; moderate weight loss (MWL), 1–10{\%} weight loss; and weight regain (WR). Body composition (dual X-ray absorptiometry) and fat oxidation (indirect calorimetry) during incremental exercise were measured at follow-up. Blood and a muscle biopsy were sampled. At follow-up, a U-shaped parabolic relationship between MFO and percent weight loss was observed (r = 0.448; P < 0.001). Overall differences between CWL, MWL, and WR were observed in MFO (mean [95{\%} confidence interval], in g/min, respectively: 0.46 [0.41–0.52]; 0.32 [0.27–0.38]; 0.45 [0.38–0.51]; P = 0.002), maximal oxygen uptake (V̇o2max, in ml·min−1·FFM−1, respectively; 49 [46–51]; 43 [40–47]; 41 [39–44]; P = 0.007), HAD-activity (in µmol·g−1·min−1, respectively: 123 [113–133]; 104 [91–118]; 97 [88–105]; P < 0.001), muscle protein content of CD36 (in AU, respectively: 1.1 [1.0–1.2]; 0.9 [0.8–1.0]; 0.9 [0.8–0.9]; P = 0.008) and FABPpm (in AU, respectively, 1.0 [0.8–1.2]; 0.7 [0.5–0.8]; 0.7 [0.5–0.9]; P = 0.008), body fat (in {\%}, respectively: 33 [29–38]; 42 [38–46]; 52 [49–55]; P < 0.001), and plasma triglycerides (in mM, respectively: 0.8 [0.7–1.0]; 1.3 [0.9–1.7]; 1.6 [1.0–2.1]; P = 0.013). CWL and WR both had higher MFO compared with MWL, but based on different mechanisms. CWL displayed higher V̇o2max and intramuscular capacity for fat oxidation, whereas abundance of lipids at whole-body level and in plasma was higher in WR",
keywords = "physical activity, adiposity, weight regain, lifestyle intervention, obesity",
author = "Sune Dandanell and Karina Husted and Signe Amdisen and Andreas Vigelso and Flemming Dela and Steen Larsen and Helge, {Jorn Wulff}",
year = "2017",
month = "7",
doi = "10.1152/japplphysiol.00270.2017",
language = "English",
volume = "123",
pages = "267--274",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Influence of maximal fat oxidation on long-term weight loss maintenance in humans

AU - Dandanell, Sune

AU - Husted, Karina

AU - Amdisen, Signe

AU - Vigelso, Andreas

AU - Dela, Flemming

AU - Larsen, Steen

AU - Helge, Jorn Wulff

PY - 2017/7

Y1 - 2017/7

N2 - Impaired maximal fat oxidation has been linked to obesity and weight regain after weight loss. The aim was to investigate the relationship between maximal fat oxidation (MFO) and long-term weight loss maintenance. Eighty subjects [means (SD): age, 36(13) yrs; BMI, 38(1) kg/m2] were recruited from a total of 2,420 former participants of an 11- to 12-wk lifestyle intervention. Three groups were established based on percent weight loss at follow-up [5.3(3.3) yr]: clinical weight loss maintenance (CWL), >10% weight loss; moderate weight loss (MWL), 1–10% weight loss; and weight regain (WR). Body composition (dual X-ray absorptiometry) and fat oxidation (indirect calorimetry) during incremental exercise were measured at follow-up. Blood and a muscle biopsy were sampled. At follow-up, a U-shaped parabolic relationship between MFO and percent weight loss was observed (r = 0.448; P < 0.001). Overall differences between CWL, MWL, and WR were observed in MFO (mean [95% confidence interval], in g/min, respectively: 0.46 [0.41–0.52]; 0.32 [0.27–0.38]; 0.45 [0.38–0.51]; P = 0.002), maximal oxygen uptake (V̇o2max, in ml·min−1·FFM−1, respectively; 49 [46–51]; 43 [40–47]; 41 [39–44]; P = 0.007), HAD-activity (in µmol·g−1·min−1, respectively: 123 [113–133]; 104 [91–118]; 97 [88–105]; P < 0.001), muscle protein content of CD36 (in AU, respectively: 1.1 [1.0–1.2]; 0.9 [0.8–1.0]; 0.9 [0.8–0.9]; P = 0.008) and FABPpm (in AU, respectively, 1.0 [0.8–1.2]; 0.7 [0.5–0.8]; 0.7 [0.5–0.9]; P = 0.008), body fat (in %, respectively: 33 [29–38]; 42 [38–46]; 52 [49–55]; P < 0.001), and plasma triglycerides (in mM, respectively: 0.8 [0.7–1.0]; 1.3 [0.9–1.7]; 1.6 [1.0–2.1]; P = 0.013). CWL and WR both had higher MFO compared with MWL, but based on different mechanisms. CWL displayed higher V̇o2max and intramuscular capacity for fat oxidation, whereas abundance of lipids at whole-body level and in plasma was higher in WR

AB - Impaired maximal fat oxidation has been linked to obesity and weight regain after weight loss. The aim was to investigate the relationship between maximal fat oxidation (MFO) and long-term weight loss maintenance. Eighty subjects [means (SD): age, 36(13) yrs; BMI, 38(1) kg/m2] were recruited from a total of 2,420 former participants of an 11- to 12-wk lifestyle intervention. Three groups were established based on percent weight loss at follow-up [5.3(3.3) yr]: clinical weight loss maintenance (CWL), >10% weight loss; moderate weight loss (MWL), 1–10% weight loss; and weight regain (WR). Body composition (dual X-ray absorptiometry) and fat oxidation (indirect calorimetry) during incremental exercise were measured at follow-up. Blood and a muscle biopsy were sampled. At follow-up, a U-shaped parabolic relationship between MFO and percent weight loss was observed (r = 0.448; P < 0.001). Overall differences between CWL, MWL, and WR were observed in MFO (mean [95% confidence interval], in g/min, respectively: 0.46 [0.41–0.52]; 0.32 [0.27–0.38]; 0.45 [0.38–0.51]; P = 0.002), maximal oxygen uptake (V̇o2max, in ml·min−1·FFM−1, respectively; 49 [46–51]; 43 [40–47]; 41 [39–44]; P = 0.007), HAD-activity (in µmol·g−1·min−1, respectively: 123 [113–133]; 104 [91–118]; 97 [88–105]; P < 0.001), muscle protein content of CD36 (in AU, respectively: 1.1 [1.0–1.2]; 0.9 [0.8–1.0]; 0.9 [0.8–0.9]; P = 0.008) and FABPpm (in AU, respectively, 1.0 [0.8–1.2]; 0.7 [0.5–0.8]; 0.7 [0.5–0.9]; P = 0.008), body fat (in %, respectively: 33 [29–38]; 42 [38–46]; 52 [49–55]; P < 0.001), and plasma triglycerides (in mM, respectively: 0.8 [0.7–1.0]; 1.3 [0.9–1.7]; 1.6 [1.0–2.1]; P = 0.013). CWL and WR both had higher MFO compared with MWL, but based on different mechanisms. CWL displayed higher V̇o2max and intramuscular capacity for fat oxidation, whereas abundance of lipids at whole-body level and in plasma was higher in WR

KW - physical activity

KW - adiposity

KW - weight regain

KW - lifestyle intervention

KW - obesity

U2 - 10.1152/japplphysiol.00270.2017

DO - 10.1152/japplphysiol.00270.2017

M3 - Journal article

C2 - 28546468

VL - 123

SP - 267

EP - 274

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -

ID: 183825093