Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H
Research output: Contribution to journal › Journal article › peer-review
It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.
|Journal||Biochimica et Biophysica Acta - Bioenergetics|
|Number of pages||6|
|Publication status||Published - Feb 2014|
- Citrate (si)-Synthase, Geography, Haplotypes, Humans, Male, Middle Aged, Mitochondria, Muscle Fibers, Skeletal, Oxidative Phosphorylation, Permeability