Immunohistochemical localization of epidermal growth factor in rat and man

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Standard

Immunohistochemical localization of epidermal growth factor in rat and man. / Poulsen, Steen Seier; Nexø, Ebba.

In: Histochemistry, Vol. 85, No. 5, 1986, p. 389-94.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS & Nexø, E 1986, 'Immunohistochemical localization of epidermal growth factor in rat and man', Histochemistry, vol. 85, no. 5, pp. 389-94.

APA

Poulsen, S. S., & Nexø, E. (1986). Immunohistochemical localization of epidermal growth factor in rat and man. Histochemistry, 85(5), 389-94.

Vancouver

Poulsen SS, Nexø E. Immunohistochemical localization of epidermal growth factor in rat and man. Histochemistry. 1986;85(5):389-94.

Author

Poulsen, Steen Seier ; Nexø, Ebba. / Immunohistochemical localization of epidermal growth factor in rat and man. In: Histochemistry. 1986 ; Vol. 85, No. 5. pp. 389-94.

Bibtex

@article{341c2c7194fa4e418163bca28a42abbf,
title = "Immunohistochemical localization of epidermal growth factor in rat and man",
abstract = "Epidermal growth factor (EGF) is a peptide which stimulates cell mitotic activity and differentiation, has a cytoprotective effect on the gastroduodenal mucosa, and inhibits gastric acid secretion. The immunohistochemical localization of EGF in the Brunner's glands and the submandibular glands is well documented. The localization of EGF in other tissues is still unclarified. In the present study, the immunohistochemical localization of EGF in tissues from rat, man and a 20 week human fetus were investigated. In man and rat, immunoreaction was found in the submandibular glands, the serous glands of the nasal cavity, Brunner's glands of the duodenum, the Paneth cells of the small intestine, and the tubular cells of the kidney. In the fetus EGF was found in the kidney and in the intestinal Paneth cells. Antisera raised against rat submandibular EGF did not recognize EGF in human tissues, whereas antisera against human urinary EGF worked in rat as well as man. EGF was found only in cells with an exocrine function.",
keywords = "Animals, Brunner Glands, Epidermal Growth Factor, Female, Fetus, Humans, Immunoenzyme Techniques, Intestine, Small, Kidney, Male, Nasal Mucosa, Rats, Rats, Inbred Strains, Submandibular Gland, Tissue Distribution",
author = "Poulsen, {Steen Seier} and Ebba Nex{\o}",
year = "1986",
language = "English",
volume = "85",
pages = "389--94",
journal = "Histochemistry",
issn = "0301-5564",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Immunohistochemical localization of epidermal growth factor in rat and man

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1986

Y1 - 1986

N2 - Epidermal growth factor (EGF) is a peptide which stimulates cell mitotic activity and differentiation, has a cytoprotective effect on the gastroduodenal mucosa, and inhibits gastric acid secretion. The immunohistochemical localization of EGF in the Brunner's glands and the submandibular glands is well documented. The localization of EGF in other tissues is still unclarified. In the present study, the immunohistochemical localization of EGF in tissues from rat, man and a 20 week human fetus were investigated. In man and rat, immunoreaction was found in the submandibular glands, the serous glands of the nasal cavity, Brunner's glands of the duodenum, the Paneth cells of the small intestine, and the tubular cells of the kidney. In the fetus EGF was found in the kidney and in the intestinal Paneth cells. Antisera raised against rat submandibular EGF did not recognize EGF in human tissues, whereas antisera against human urinary EGF worked in rat as well as man. EGF was found only in cells with an exocrine function.

AB - Epidermal growth factor (EGF) is a peptide which stimulates cell mitotic activity and differentiation, has a cytoprotective effect on the gastroduodenal mucosa, and inhibits gastric acid secretion. The immunohistochemical localization of EGF in the Brunner's glands and the submandibular glands is well documented. The localization of EGF in other tissues is still unclarified. In the present study, the immunohistochemical localization of EGF in tissues from rat, man and a 20 week human fetus were investigated. In man and rat, immunoreaction was found in the submandibular glands, the serous glands of the nasal cavity, Brunner's glands of the duodenum, the Paneth cells of the small intestine, and the tubular cells of the kidney. In the fetus EGF was found in the kidney and in the intestinal Paneth cells. Antisera raised against rat submandibular EGF did not recognize EGF in human tissues, whereas antisera against human urinary EGF worked in rat as well as man. EGF was found only in cells with an exocrine function.

KW - Animals

KW - Brunner Glands

KW - Epidermal Growth Factor

KW - Female

KW - Fetus

KW - Humans

KW - Immunoenzyme Techniques

KW - Intestine, Small

KW - Kidney

KW - Male

KW - Nasal Mucosa

KW - Rats

KW - Rats, Inbred Strains

KW - Submandibular Gland

KW - Tissue Distribution

M3 - Journal article

C2 - 3536807

VL - 85

SP - 389

EP - 394

JO - Histochemistry

JF - Histochemistry

SN - 0301-5564

IS - 5

ER -

ID: 47488977