Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

Research output: Contribution to journalJournal articleResearchpeer-review

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Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. / Binderup, Tina; Duivenvoorden, Raphaël; Fay, Francois; Van Leent, Mandy M.T.; Malkus, Joost; Baxter, Samantha; Ishino, Seigo; Zhao, Yiming; Sanchez-Gaytan, Brenda; Teunissen, Abraham J.P.; Frederico, Yohana C.A.; Tang, Jun; Carlucci, Giuseppe; Lyashchenko, Serge; Calcagno, Claudia; Karakatsanis, Nicolas; Soultanidis, Georgios; Senders, Max L.; Robson, Philip M.; Mani, Venkatesh; Ramachandran, Sarayu; Lobatto, Mark E.; Hutten, Barbara A.; Granada, Juan F.; Reiner, Thomas; Swirski, Filip K.; Nahrendorf, Matthias; Kjaer, Andreas; Fisher, Edward A.; Fayad, Zahi A.; Pérez-Medina, Carlos; Mulder, Willem J.M.

In: Science Translational Medicine, Vol. 11, No. 506, eaaw7736, 08.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Binderup, T, Duivenvoorden, R, Fay, F, Van Leent, MMT, Malkus, J, Baxter, S, Ishino, S, Zhao, Y, Sanchez-Gaytan, B, Teunissen, AJP, Frederico, YCA, Tang, J, Carlucci, G, Lyashchenko, S, Calcagno, C, Karakatsanis, N, Soultanidis, G, Senders, ML, Robson, PM, Mani, V, Ramachandran, S, Lobatto, ME, Hutten, BA, Granada, JF, Reiner, T, Swirski, FK, Nahrendorf, M, Kjaer, A, Fisher, EA, Fayad, ZA, Pérez-Medina, C & Mulder, WJM 2019, 'Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species', Science Translational Medicine, vol. 11, no. 506, eaaw7736. https://doi.org/10.1126/scitranslmed.aaw7736

APA

Binderup, T., Duivenvoorden, R., Fay, F., Van Leent, M. M. T., Malkus, J., Baxter, S., ... Mulder, W. J. M. (2019). Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. Science Translational Medicine, 11(506), [eaaw7736]. https://doi.org/10.1126/scitranslmed.aaw7736

Vancouver

Binderup T, Duivenvoorden R, Fay F, Van Leent MMT, Malkus J, Baxter S et al. Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. Science Translational Medicine. 2019 Aug;11(506). eaaw7736. https://doi.org/10.1126/scitranslmed.aaw7736

Author

Binderup, Tina ; Duivenvoorden, Raphaël ; Fay, Francois ; Van Leent, Mandy M.T. ; Malkus, Joost ; Baxter, Samantha ; Ishino, Seigo ; Zhao, Yiming ; Sanchez-Gaytan, Brenda ; Teunissen, Abraham J.P. ; Frederico, Yohana C.A. ; Tang, Jun ; Carlucci, Giuseppe ; Lyashchenko, Serge ; Calcagno, Claudia ; Karakatsanis, Nicolas ; Soultanidis, Georgios ; Senders, Max L. ; Robson, Philip M. ; Mani, Venkatesh ; Ramachandran, Sarayu ; Lobatto, Mark E. ; Hutten, Barbara A. ; Granada, Juan F. ; Reiner, Thomas ; Swirski, Filip K. ; Nahrendorf, Matthias ; Kjaer, Andreas ; Fisher, Edward A. ; Fayad, Zahi A. ; Pérez-Medina, Carlos ; Mulder, Willem J.M. / Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. In: Science Translational Medicine. 2019 ; Vol. 11, No. 506.

Bibtex

@article{4fbe3426f11040d5867f1354e15a0a3e,
title = "Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species",
abstract = "Nanomedicine research produces hundreds of studies every year, yet very few formulations have been approved for clinical use. This is due in part to a reliance on murine studies, which have limited value in accurately predicting translational efficacy in larger animal models and humans. Here, we report the scale-up of a nanoimmunotherapy from mouse to large rabbit and porcine atherosclerosis models, with an emphasis on the solutions we implemented to overcome production and evaluation challenges. Specifically, we integrated translational imaging readouts within our workflow to both analyze the nanoimmunotherapeutic's in vivo behavior and assess treatment response in larger animals. We observed our nanoimmunotherapeutic's anti-inflammatory efficacy in mice, as well as rabbits and pigs. Nanoimmunotherapy-mediated reduction of inflammation in the large animal models halted plaque progression, supporting the approach's translatability and potential to acutely treat atherosclerosis.",
author = "Tina Binderup and Rapha{\"e}l Duivenvoorden and Francois Fay and {Van Leent}, {Mandy M.T.} and Joost Malkus and Samantha Baxter and Seigo Ishino and Yiming Zhao and Brenda Sanchez-Gaytan and Teunissen, {Abraham J.P.} and Frederico, {Yohana C.A.} and Jun Tang and Giuseppe Carlucci and Serge Lyashchenko and Claudia Calcagno and Nicolas Karakatsanis and Georgios Soultanidis and Senders, {Max L.} and Robson, {Philip M.} and Venkatesh Mani and Sarayu Ramachandran and Lobatto, {Mark E.} and Hutten, {Barbara A.} and Granada, {Juan F.} and Thomas Reiner and Swirski, {Filip K.} and Matthias Nahrendorf and Andreas Kjaer and Fisher, {Edward A.} and Fayad, {Zahi A.} and Carlos P{\'e}rez-Medina and Mulder, {Willem J.M.}",
year = "2019",
month = "8",
doi = "10.1126/scitranslmed.aaw7736",
language = "English",
volume = "11",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "american association for the advancement of science",
number = "506",

}

RIS

TY - JOUR

T1 - Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

AU - Binderup, Tina

AU - Duivenvoorden, Raphaël

AU - Fay, Francois

AU - Van Leent, Mandy M.T.

AU - Malkus, Joost

AU - Baxter, Samantha

AU - Ishino, Seigo

AU - Zhao, Yiming

AU - Sanchez-Gaytan, Brenda

AU - Teunissen, Abraham J.P.

AU - Frederico, Yohana C.A.

AU - Tang, Jun

AU - Carlucci, Giuseppe

AU - Lyashchenko, Serge

AU - Calcagno, Claudia

AU - Karakatsanis, Nicolas

AU - Soultanidis, Georgios

AU - Senders, Max L.

AU - Robson, Philip M.

AU - Mani, Venkatesh

AU - Ramachandran, Sarayu

AU - Lobatto, Mark E.

AU - Hutten, Barbara A.

AU - Granada, Juan F.

AU - Reiner, Thomas

AU - Swirski, Filip K.

AU - Nahrendorf, Matthias

AU - Kjaer, Andreas

AU - Fisher, Edward A.

AU - Fayad, Zahi A.

AU - Pérez-Medina, Carlos

AU - Mulder, Willem J.M.

PY - 2019/8

Y1 - 2019/8

N2 - Nanomedicine research produces hundreds of studies every year, yet very few formulations have been approved for clinical use. This is due in part to a reliance on murine studies, which have limited value in accurately predicting translational efficacy in larger animal models and humans. Here, we report the scale-up of a nanoimmunotherapy from mouse to large rabbit and porcine atherosclerosis models, with an emphasis on the solutions we implemented to overcome production and evaluation challenges. Specifically, we integrated translational imaging readouts within our workflow to both analyze the nanoimmunotherapeutic's in vivo behavior and assess treatment response in larger animals. We observed our nanoimmunotherapeutic's anti-inflammatory efficacy in mice, as well as rabbits and pigs. Nanoimmunotherapy-mediated reduction of inflammation in the large animal models halted plaque progression, supporting the approach's translatability and potential to acutely treat atherosclerosis.

AB - Nanomedicine research produces hundreds of studies every year, yet very few formulations have been approved for clinical use. This is due in part to a reliance on murine studies, which have limited value in accurately predicting translational efficacy in larger animal models and humans. Here, we report the scale-up of a nanoimmunotherapy from mouse to large rabbit and porcine atherosclerosis models, with an emphasis on the solutions we implemented to overcome production and evaluation challenges. Specifically, we integrated translational imaging readouts within our workflow to both analyze the nanoimmunotherapeutic's in vivo behavior and assess treatment response in larger animals. We observed our nanoimmunotherapeutic's anti-inflammatory efficacy in mice, as well as rabbits and pigs. Nanoimmunotherapy-mediated reduction of inflammation in the large animal models halted plaque progression, supporting the approach's translatability and potential to acutely treat atherosclerosis.

U2 - 10.1126/scitranslmed.aaw7736

DO - 10.1126/scitranslmed.aaw7736

M3 - Journal article

C2 - 31434756

AN - SCOPUS:85071299820

VL - 11

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 506

M1 - eaaw7736

ER -

ID: 240685737