Imaging of Prostate Cancer Using Urokinase-Type Plasminogen Activator Receptor PET
Research output: Contribution to journal › Review › Research › peer-review
Urokinase-type plasminogen activator receptor (uPAR) overexpression is an important biomarker for aggressiveness in cancer including prostate cancer (PC) and provides independent clinical information in addition to prostate-specific antigen and Gleason score. This article focuses on uPAR PET as a new diagnostic and prognostic imaging biomarker in PC. Many preclinical uPAR-targeted PET imaging studies using AE105 in cancer models have been undertaken with promising results. A major breakthrough was obtained with the recent human translation of uPAR PET in using 64Cu- and 68Ga-labelled versions of AE105, respectively. Clinical results from patients with PC included in these studies are encouraging and support continuation with large-scale clinical trials.
Original language | English |
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Journal | PET Clinics |
Volume | 12 |
Issue number | 2 |
Pages (from-to) | 243-255 |
Number of pages | 13 |
ISSN | 1556-8598 |
DOIs | |
Publication status | Published - Apr 2017 |
- Molecular imaging, PET, Prostate cancer, Radionuclide imaging, Theranostics, uPAR
Research areas
ID: 196048622