Hypothiocyanous acid - benign or deadly?

Research output: Contribution to journalJournal articlepeer-review

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Hypothiocyanous acid - benign or deadly? / Barrett, Tessa J; Hawkins, Clare L.

In: Chemical Research in Toxicology, Vol. 25, No. 2, 20.02.2012, p. 263-73.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Barrett, TJ & Hawkins, CL 2012, 'Hypothiocyanous acid - benign or deadly?', Chemical Research in Toxicology, vol. 25, no. 2, pp. 263-73. https://doi.org/10.1021/tx200219s

APA

Barrett, T. J., & Hawkins, C. L. (2012). Hypothiocyanous acid - benign or deadly? Chemical Research in Toxicology, 25(2), 263-73. https://doi.org/10.1021/tx200219s

Vancouver

Barrett TJ, Hawkins CL. Hypothiocyanous acid - benign or deadly? Chemical Research in Toxicology. 2012 Feb 20;25(2):263-73. https://doi.org/10.1021/tx200219s

Author

Barrett, Tessa J ; Hawkins, Clare L. / Hypothiocyanous acid - benign or deadly?. In: Chemical Research in Toxicology. 2012 ; Vol. 25, No. 2. pp. 263-73.

Bibtex

@article{0e435e10a4a14e7ab2804427d42647c4,
title = "Hypothiocyanous acid - benign or deadly?",
abstract = "Hypothiocyanous acid (HOSCN) is produced in biological systems by the peroxidase-catalyzed reaction of thiocyanate (SCN(-)) with H(2)O(2). This oxidant plays an important role in the human immune system, owing to its potent bacteriostatic properties. Significant amounts of HOSCN are also formed by immune cells under inflammatory conditions, yet the reactivity of this oxidant with host tissue is poorly characterized. Traditionally, HOSCN has been viewed as a mild oxidant, which is innocuous to mammalian cells. Indeed, recent studies show that the presence of SCN(-) in airways has a protective function, by preventing the formation of other, more damaging, inflammatory oxidants. However, there is an increasing body of evidence that challenges this dogma, showing that the selectivity of HOSCN for specific thiol-containing cellular targets results in the initiation of significant cellular damage. This propensity to induce cellular dysfunction is gaining considerable interest, particularly in the cardiovascular field, as smokers have elevated plasma SCN(-), the precursor for HOSCN. This review will outline the beneficial and detrimental aspects of HOSCN formation in biological systems.",
keywords = "Animals, Cardiovascular Diseases, Cystic Fibrosis, Humans, Lung, Mouth, Thiocyanates, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Barrett, {Tessa J} and Hawkins, {Clare L}",
year = "2012",
month = feb,
day = "20",
doi = "10.1021/tx200219s",
language = "English",
volume = "25",
pages = "263--73",
journal = "Chemical Research in Toxicology",
issn = "0893-228X",
publisher = "American Chemical Society",
number = "2",

}

RIS

TY - JOUR

T1 - Hypothiocyanous acid - benign or deadly?

AU - Barrett, Tessa J

AU - Hawkins, Clare L

PY - 2012/2/20

Y1 - 2012/2/20

N2 - Hypothiocyanous acid (HOSCN) is produced in biological systems by the peroxidase-catalyzed reaction of thiocyanate (SCN(-)) with H(2)O(2). This oxidant plays an important role in the human immune system, owing to its potent bacteriostatic properties. Significant amounts of HOSCN are also formed by immune cells under inflammatory conditions, yet the reactivity of this oxidant with host tissue is poorly characterized. Traditionally, HOSCN has been viewed as a mild oxidant, which is innocuous to mammalian cells. Indeed, recent studies show that the presence of SCN(-) in airways has a protective function, by preventing the formation of other, more damaging, inflammatory oxidants. However, there is an increasing body of evidence that challenges this dogma, showing that the selectivity of HOSCN for specific thiol-containing cellular targets results in the initiation of significant cellular damage. This propensity to induce cellular dysfunction is gaining considerable interest, particularly in the cardiovascular field, as smokers have elevated plasma SCN(-), the precursor for HOSCN. This review will outline the beneficial and detrimental aspects of HOSCN formation in biological systems.

AB - Hypothiocyanous acid (HOSCN) is produced in biological systems by the peroxidase-catalyzed reaction of thiocyanate (SCN(-)) with H(2)O(2). This oxidant plays an important role in the human immune system, owing to its potent bacteriostatic properties. Significant amounts of HOSCN are also formed by immune cells under inflammatory conditions, yet the reactivity of this oxidant with host tissue is poorly characterized. Traditionally, HOSCN has been viewed as a mild oxidant, which is innocuous to mammalian cells. Indeed, recent studies show that the presence of SCN(-) in airways has a protective function, by preventing the formation of other, more damaging, inflammatory oxidants. However, there is an increasing body of evidence that challenges this dogma, showing that the selectivity of HOSCN for specific thiol-containing cellular targets results in the initiation of significant cellular damage. This propensity to induce cellular dysfunction is gaining considerable interest, particularly in the cardiovascular field, as smokers have elevated plasma SCN(-), the precursor for HOSCN. This review will outline the beneficial and detrimental aspects of HOSCN formation in biological systems.

KW - Animals

KW - Cardiovascular Diseases

KW - Cystic Fibrosis

KW - Humans

KW - Lung

KW - Mouth

KW - Thiocyanates

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1021/tx200219s

DO - 10.1021/tx200219s

M3 - Journal article

C2 - 22053976

VL - 25

SP - 263

EP - 273

JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

SN - 0893-228X

IS - 2

ER -

ID: 174497372