Standard
Hundreds of variants clustered in genomic loci and biological pathways affect human height. / Lango Allen, Hana; Estrada, Karol; Lettre, Guillaume; Berndt, Sonja I; Weedon, Michael N; Rivadeneira, Fernando; Willer, Cristen J; Jackson, Anne U; Vedantam, Sailaja; Raychaudhuri, Soumya; Ferreira, Teresa; Wood, Andrew R; Weyant, Robert J; Segrè, Ayellet V; Speliotes, Elizabeth K; Wheeler, Eleanor; Soranzo, Nicole; Park, Ju-Hyun; Yang, Jian; Gudbjartsson, Daniel; Heard-Costa, Nancy L; Randall, Joshua C; Qi, Lu; Vernon Smith, Albert; Mägi, Reedik; Pastinen, Tomi; Liang, Liming; Heid, Iris M; Luan, Jian'an; Thorleifsson, Gudmar; Winkler, Thomas W; Goddard, Michael E; Sin Lo, Ken; Palmer, Cameron; Workalemahu, Tsegaselassie; Aulchenko, Yurii S; Johansson, Asa; Zillikens, M Carola; Feitosa, Mary F; Esko, Tõnu; Johnson, Toby; Ketkar, Shamika; Kraft, Peter; Mangino, Massimo; Prokopenko, Inga; Absher, Devin; Albrecht, Eva; Ernst, Florian; Glazer, Nicole L; Hayward, Caroline; Hottenga, Jouke-Jan; Jacobs, Kevin B; Knowles, Joshua W; Kutalik, Zoltán; Monda, Keri L; Polasek, Ozren; Preuss, Michael; Rayner, Nigel W; Robertson, Neil R; Steinthorsdottir, Valgerdur; Tyrer, Jonathan P; Voight, Benjamin F; Wiklund, Fredrik; Xu, Jianfeng; Zhao, Jing Hua; Nyholt, Dale R; Pellikka, Niina; Perola, Markus; Perry, John R B; Surakka, Ida; Tammesoo, Mari-Liis; Altmaier, Elizabeth L; Amin, Najaf; Aspelund, Thor; Bhangale, Tushar; Boucher, Gabrielle; Chasman, Daniel I; Chen, Constance; Coin, Lachlan; Cooper, Matthew N; Dixon, Anna L; Gibson, Quince; Grundberg, Elin; Hao, Ke; Juhani Junttila, M; Kaplan, Lee M; Kettunen, Johannes; König, Inke R; Kwan, Tony; Lawrence, Robert W; Levinson, Douglas F; Lorentzon, Mattias; McKnight, Barbara; Morris, Andrew P; Müller, Martina; Suh Ngwa, Julius; Purcell, Shaun; Rafelt, Suzanne; Salem, Rany M; Salvi, Erika; Sanna, Serena; Shi, Jianxin; Sovio, Ulla; Thompson, John R; Turchin, Michael C; Vandenput, Liesbeth; Verlaan, Dominique J; Vitart, Veronique; White, Charles C; Ziegler, Andreas; Almgren, Peter; Balmforth, Anthony J; Campbell, Harry; Citterio, Lorena; De Grandi, Alessandro; Dominiczak, Anna; Duan, Jubao; Elliott, Paul; Elosua, Roberto; Eriksson, Johan G; Freimer, Nelson B; Geus, Eco J C; Glorioso, Nicola; Haiqing, Shen; Hartikainen, Anna-Liisa; Havulinna, Aki S; Hicks, Andrew A; Hui, Jennie; Igl, Wilmar; Illig, Thomas; Jula, Antti; Kajantie, Eero; Oskari Kilpeläinen, Tuomas; Koiranen, Markku; Kolcic, Ivana; Koskinen, Seppo; Kovacs, Peter; Laitinen, Jaana; Liu, Jianjun; Lokki, Marja-Liisa; Marusic, Ana; Maschio, Andrea; Meitinger, Thomas; Mulas, Antonella; Paré, Guillaume; Parker, Alex N; Peden, John F; Petersmann, Astrid; Pichler, Irene; Pietiläinen, Kirsi H; Pouta, Anneli; Ridderstråle, Martin; Rotter, Jerome I; Sambrook, Jennifer G; Sanders, Alan R; Schmidt, Carsten Oliver; Sinisalo, Juha; Smit, Jan H; Stringham, Heather M; Bragi Walters, G; Widen, Elisabeth; Wild, Sarah H; Willemsen, Gonneke; Zagato, Laura; Zgaga, Lina; Zitting, Paavo; Alavere, Helene; Farrall, Martin; McArdle, Wendy L; Nelis, Mari; Peters, Marjolein J; Ripatti, Samuli; van Meurs, Joyce B J; Aben, Katja K; Ardlie, Kristin G; Beckmann, Jacques S; Beilby, John P; Bergman, Richard N; Bergmann, Sven; Collins, Francis S; Cusi, Daniele; den Heijer, Martin; Eiriksdottir, Gudny; Gejman, Pablo V; Hall, Alistair S; Hamsten, Anders; Huikuri, Heikki V; Iribarren, Carlos; Kähönen, Mika; Kaprio, Jaakko; Kathiresan, Sekar; Kiemeney, Lambertus; Kocher, Thomas; Launer, Lenore J; Lehtimäki, Terho; Melander, Olle; Mosley, Tom H; Musk, Arthur W; Nieminen, Markku S; O'Donnell, Christopher J; Ohlsson, Claes; Oostra, Ben; Palmer, Lyle J; Raitakari, Olli; Ridker, Paul M; Rioux, John D; Rissanen, Aila; Rivolta, Carlo; Schunkert, Heribert; Shuldiner, Alan R; Siscovick, David S; Stumvoll, Michael; Tönjes, Anke; Tuomilehto, Jaakko; van Ommen, Gert-Jan; Viikari, Jorma; Heath, Andrew C; Martin, Nicholas G; Montgomery, Grant W; Province, Michael A; Kayser, Manfred; Arnold, Alice M; Atwood, Larry D; Boerwinkle, Eric; Chanock, Stephen J; Deloukas, Panos; Gieger, Christian; Grönberg, Henrik; Hall, Per; Hattersley, Andrew T; Hengstenberg, Christian; Hoffman, Wolfgang; Lathrop, G Mark; Salomaa, Veikko; Schreiber, Stefan; Uda, Manuela; Waterworth, Dawn; Wright, Alan F; Assimes, Themistocles L; Barroso, Inês; Hofman, Albert; Mohlke, Karen L; Boomsma, Dorret I; Caulfield, Mark J; Cupples, L Adrienne; Erdmann, Jeanette; Fox, Caroline S; Gudnason, Vilmundur; Gyllensten, Ulf; Harris, Tamara B; Hayes, Richard B; Jarvelin, Marjo-Riitta; Mooser, Vincent; Munroe, Patricia B; Ouwehand, Willem H; Penninx, Brenda W; Pramstaller, Peter P; Quertermous, Thomas; Rudan, Igor; Samani, Nilesh J; Spector, Timothy D; Völzke, Henry; Watkins, Hugh; Wilson, James; Groop, Leif C; Haritunians, Talin; Hu, Frank B; Kaplan, Robert C; Metspalu, Andres; North, Kari E; Schlessinger, David; Wareham, Nicholas J; Hunter, David J; O'Connell, Jeffrey R; Strachan, David P; Wichmann, H-Erich; Borecki, Ingrid B; van Duijn, Cornelia M; Schadt, Eric E; Thorsteinsdottir, Unnur; Peltonen, Leena; Uitterlinden, André G; Visscher, Peter M; Chatterjee, Nilanjan; Loos, Ruth J F; Boehnke, Michael; McCarthy, Mark I; Ingelsson, Erik; Lindgren, Cecilia M; Abecasis, Gonçalo R; Stefansson, Kari; Frayling, Timothy M; Hirschhorn, Joel N.
In:
Nature, Vol. 467, No. 7317, 14.10.2010, p. 832-8.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Lango Allen, H, Estrada, K, Lettre, G, Berndt, SI, Weedon, MN, Rivadeneira, F, Willer, CJ, Jackson, AU, Vedantam, S, Raychaudhuri, S, Ferreira, T, Wood, AR, Weyant, RJ, Segrè, AV, Speliotes, EK, Wheeler, E, Soranzo, N, Park, J-H, Yang, J, Gudbjartsson, D, Heard-Costa, NL, Randall, JC, Qi, L, Vernon Smith, A, Mägi, R, Pastinen, T, Liang, L, Heid, IM, Luan, J, Thorleifsson, G, Winkler, TW, Goddard, ME, Sin Lo, K, Palmer, C, Workalemahu, T, Aulchenko, YS, Johansson, A, Zillikens, MC, Feitosa, MF, Esko, T, Johnson, T, Ketkar, S, Kraft, P, Mangino, M, Prokopenko, I, Absher, D, Albrecht, E, Ernst, F, Glazer, NL, Hayward, C, Hottenga, J-J, Jacobs, KB, Knowles, JW, Kutalik, Z, Monda, KL, Polasek, O, Preuss, M, Rayner, NW, Robertson, NR, Steinthorsdottir, V, Tyrer, JP, Voight, BF, Wiklund, F, Xu, J, Zhao, JH, Nyholt, DR, Pellikka, N, Perola, M, Perry, JRB, Surakka, I, Tammesoo, M-L, Altmaier, EL, Amin, N, Aspelund, T, Bhangale, T, Boucher, G, Chasman, DI, Chen, C, Coin, L, Cooper, MN, Dixon, AL, Gibson, Q, Grundberg, E, Hao, K, Juhani Junttila, M, Kaplan, LM, Kettunen, J, König, IR, Kwan, T, Lawrence, RW, Levinson, DF, Lorentzon, M, McKnight, B, Morris, AP, Müller, M, Suh Ngwa, J, Purcell, S, Rafelt, S, Salem, RM, Salvi, E, Sanna, S, Shi, J, Sovio, U, Thompson, JR, Turchin, MC, Vandenput, L, Verlaan, DJ, Vitart, V, White, CC, Ziegler, A, Almgren, P, Balmforth, AJ, Campbell, H, Citterio, L, De Grandi, A, Dominiczak, A, Duan, J, Elliott, P, Elosua, R, Eriksson, JG, Freimer, NB, Geus, EJC, Glorioso, N, Haiqing, S, Hartikainen, A-L, Havulinna, AS, Hicks, AA, Hui, J, Igl, W, Illig, T, Jula, A, Kajantie, E
, Oskari Kilpeläinen, T, Koiranen, M, Kolcic, I, Koskinen, S, Kovacs, P, Laitinen, J, Liu, J, Lokki, M-L, Marusic, A, Maschio, A, Meitinger, T, Mulas, A, Paré, G, Parker, AN, Peden, JF, Petersmann, A, Pichler, I, Pietiläinen, KH, Pouta, A, Ridderstråle, M, Rotter, JI, Sambrook, JG, Sanders, AR, Schmidt, CO, Sinisalo, J, Smit, JH, Stringham, HM, Bragi Walters, G, Widen, E, Wild, SH, Willemsen, G, Zagato, L, Zgaga, L, Zitting, P, Alavere, H, Farrall, M, McArdle, WL, Nelis, M, Peters, MJ, Ripatti, S, van Meurs, JBJ, Aben, KK, Ardlie, KG, Beckmann, JS, Beilby, JP, Bergman, RN, Bergmann, S, Collins, FS, Cusi, D, den Heijer, M, Eiriksdottir, G, Gejman, PV, Hall, AS, Hamsten, A, Huikuri, HV, Iribarren, C, Kähönen, M, Kaprio, J, Kathiresan, S, Kiemeney, L, Kocher, T, Launer, LJ, Lehtimäki, T, Melander, O, Mosley, TH, Musk, AW, Nieminen, MS, O'Donnell, CJ, Ohlsson, C, Oostra, B, Palmer, LJ, Raitakari, O, Ridker, PM, Rioux, JD, Rissanen, A, Rivolta, C, Schunkert, H, Shuldiner, AR, Siscovick, DS, Stumvoll, M, Tönjes, A, Tuomilehto, J, van Ommen, G-J, Viikari, J, Heath, AC, Martin, NG, Montgomery, GW, Province, MA, Kayser, M, Arnold, AM, Atwood, LD, Boerwinkle, E, Chanock, SJ, Deloukas, P, Gieger, C, Grönberg, H, Hall, P, Hattersley, AT, Hengstenberg, C, Hoffman, W, Lathrop, GM, Salomaa, V, Schreiber, S, Uda, M, Waterworth, D, Wright, AF, Assimes, TL, Barroso, I, Hofman, A, Mohlke, KL, Boomsma, DI, Caulfield, MJ, Cupples, LA, Erdmann, J, Fox, CS, Gudnason, V, Gyllensten, U, Harris, TB, Hayes, RB, Jarvelin, M-R, Mooser, V, Munroe, PB, Ouwehand, WH, Penninx, BW, Pramstaller, PP, Quertermous, T, Rudan, I, Samani, NJ, Spector, TD, Völzke, H, Watkins, H, Wilson, J, Groop, LC, Haritunians, T, Hu, FB, Kaplan, RC, Metspalu, A, North, KE, Schlessinger, D, Wareham, NJ, Hunter, DJ, O'Connell, JR, Strachan, DP, Wichmann, H-E, Borecki, IB, van Duijn, CM, Schadt, EE, Thorsteinsdottir, U, Peltonen, L, Uitterlinden, AG, Visscher, PM, Chatterjee, N, Loos, RJF, Boehnke, M, McCarthy, MI, Ingelsson, E, Lindgren, CM, Abecasis, GR, Stefansson, K, Frayling, TM & Hirschhorn, JN 2010, '
Hundreds of variants clustered in genomic loci and biological pathways affect human height',
Nature, vol. 467, no. 7317, pp. 832-8.
https://doi.org/10.1038/nature09410APA
Lango Allen, H., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Willer, C. J., Jackson, A. U., Vedantam, S., Raychaudhuri, S., Ferreira, T., Wood, A. R., Weyant, R. J., Segrè, A. V., Speliotes, E. K., Wheeler, E., Soranzo, N., Park, J-H., Yang, J., ... Hirschhorn, J. N. (2010).
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Nature,
467(7317), 832-8.
https://doi.org/10.1038/nature09410Vancouver
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F et al.
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Nature. 2010 Oct 14;467(7317):832-8.
https://doi.org/10.1038/nature09410Author
Lango Allen, Hana ; Estrada, Karol ; Lettre, Guillaume ; Berndt, Sonja I ; Weedon, Michael N ; Rivadeneira, Fernando ; Willer, Cristen J ; Jackson, Anne U ; Vedantam, Sailaja ; Raychaudhuri, Soumya ; Ferreira, Teresa ; Wood, Andrew R ; Weyant, Robert J ; Segrè, Ayellet V ; Speliotes, Elizabeth K ; Wheeler, Eleanor ; Soranzo, Nicole ; Park, Ju-Hyun ; Yang, Jian ; Gudbjartsson, Daniel ; Heard-Costa, Nancy L ; Randall, Joshua C ; Qi, Lu ; Vernon Smith, Albert ; Mägi, Reedik ; Pastinen, Tomi ; Liang, Liming ; Heid, Iris M ; Luan, Jian'an ; Thorleifsson, Gudmar ; Winkler, Thomas W ; Goddard, Michael E ; Sin Lo, Ken ; Palmer, Cameron ; Workalemahu, Tsegaselassie ; Aulchenko, Yurii S ; Johansson, Asa ; Zillikens, M Carola ; Feitosa, Mary F ; Esko, Tõnu ; Johnson, Toby ; Ketkar, Shamika ; Kraft, Peter ; Mangino, Massimo ; Prokopenko, Inga ; Absher, Devin ; Albrecht, Eva ; Ernst, Florian ; Glazer, Nicole L ; Hayward, Caroline ; Hottenga, Jouke-Jan ; Jacobs, Kevin B ; Knowles, Joshua W ; Kutalik, Zoltán ; Monda, Keri L ; Polasek, Ozren ; Preuss, Michael ; Rayner, Nigel W ; Robertson, Neil R ; Steinthorsdottir, Valgerdur ; Tyrer, Jonathan P ; Voight, Benjamin F ; Wiklund, Fredrik ; Xu, Jianfeng ; Zhao, Jing Hua ; Nyholt, Dale R ; Pellikka, Niina ; Perola, Markus ; Perry, John R B ; Surakka, Ida ; Tammesoo, Mari-Liis ; Altmaier, Elizabeth L ; Amin, Najaf ; Aspelund, Thor ; Bhangale, Tushar ; Boucher, Gabrielle ; Chasman, Daniel I ; Chen, Constance ; Coin, Lachlan ; Cooper, Matthew N ; Dixon, Anna L ; Gibson, Quince ; Grundberg, Elin ; Hao, Ke ; Juhani Junttila, M ; Kaplan, Lee M ; Kettunen, Johannes ; König, Inke R ; Kwan, Tony ; Lawrence, Robert W ; Levinson, Douglas F ; Lorentzon, Mattias ; McKnight, Barbara ; Morris, Andrew P ; Müller, Martina ; Suh Ngwa, Julius ; Purcell, Shaun ; Rafelt, Suzanne ; Salem, Rany M ; Salvi, Erika ; Sanna, Serena ; Shi, Jianxin ; Sovio, Ulla ; Thompson, John R ; Turchin, Michael C ; Vandenput, Liesbeth ; Verlaan, Dominique J ; Vitart, Veronique ; White, Charles C ; Ziegler, Andreas ; Almgren, Peter ; Balmforth, Anthony J ; Campbell, Harry ; Citterio, Lorena ; De Grandi, Alessandro ; Dominiczak, Anna ; Duan, Jubao ; Elliott, Paul ; Elosua, Roberto ; Eriksson, Johan G ; Freimer, Nelson B ; Geus, Eco J C ; Glorioso, Nicola ; Haiqing, Shen ; Hartikainen, Anna-Liisa ; Havulinna, Aki S ; Hicks, Andrew A ; Hui, Jennie ; Igl, Wilmar ; Illig, Thomas ; Jula, Antti ; Kajantie, Eero ; Oskari Kilpeläinen, Tuomas ; Koiranen, Markku ; Kolcic, Ivana ; Koskinen, Seppo ; Kovacs, Peter ; Laitinen, Jaana ; Liu, Jianjun ; Lokki, Marja-Liisa ; Marusic, Ana ; Maschio, Andrea ; Meitinger, Thomas ; Mulas, Antonella ; Paré, Guillaume ; Parker, Alex N ; Peden, John F ; Petersmann, Astrid ; Pichler, Irene ; Pietiläinen, Kirsi H ; Pouta, Anneli ; Ridderstråle, Martin ; Rotter, Jerome I ; Sambrook, Jennifer G ; Sanders, Alan R ; Schmidt, Carsten Oliver ; Sinisalo, Juha ; Smit, Jan H ; Stringham, Heather M ; Bragi Walters, G ; Widen, Elisabeth ; Wild, Sarah H ; Willemsen, Gonneke ; Zagato, Laura ; Zgaga, Lina ; Zitting, Paavo ; Alavere, Helene ; Farrall, Martin ; McArdle, Wendy L ; Nelis, Mari ; Peters, Marjolein J ; Ripatti, Samuli ; van Meurs, Joyce B J ; Aben, Katja K ; Ardlie, Kristin G ; Beckmann, Jacques S ; Beilby, John P ; Bergman, Richard N ; Bergmann, Sven ; Collins, Francis S ; Cusi, Daniele ; den Heijer, Martin ; Eiriksdottir, Gudny ; Gejman, Pablo V ; Hall, Alistair S ; Hamsten, Anders ; Huikuri, Heikki V ; Iribarren, Carlos ; Kähönen, Mika ; Kaprio, Jaakko ; Kathiresan, Sekar ; Kiemeney, Lambertus ; Kocher, Thomas ; Launer, Lenore J ; Lehtimäki, Terho ; Melander, Olle ; Mosley, Tom H ; Musk, Arthur W ; Nieminen, Markku S ; O'Donnell, Christopher J ; Ohlsson, Claes ; Oostra, Ben ; Palmer, Lyle J ; Raitakari, Olli ; Ridker, Paul M ; Rioux, John D ; Rissanen, Aila ; Rivolta, Carlo ; Schunkert, Heribert ; Shuldiner, Alan R ; Siscovick, David S ; Stumvoll, Michael ; Tönjes, Anke ; Tuomilehto, Jaakko ; van Ommen, Gert-Jan ; Viikari, Jorma ; Heath, Andrew C ; Martin, Nicholas G ; Montgomery, Grant W ; Province, Michael A ; Kayser, Manfred ; Arnold, Alice M ; Atwood, Larry D ; Boerwinkle, Eric ; Chanock, Stephen J ; Deloukas, Panos ; Gieger, Christian ; Grönberg, Henrik ; Hall, Per ; Hattersley, Andrew T ; Hengstenberg, Christian ; Hoffman, Wolfgang ; Lathrop, G Mark ; Salomaa, Veikko ; Schreiber, Stefan ; Uda, Manuela ; Waterworth, Dawn ; Wright, Alan F ; Assimes, Themistocles L ; Barroso, Inês ; Hofman, Albert ; Mohlke, Karen L ; Boomsma, Dorret I ; Caulfield, Mark J ; Cupples, L Adrienne ; Erdmann, Jeanette ; Fox, Caroline S ; Gudnason, Vilmundur ; Gyllensten, Ulf ; Harris, Tamara B ; Hayes, Richard B ; Jarvelin, Marjo-Riitta ; Mooser, Vincent ; Munroe, Patricia B ; Ouwehand, Willem H ; Penninx, Brenda W ; Pramstaller, Peter P ; Quertermous, Thomas ; Rudan, Igor ; Samani, Nilesh J ; Spector, Timothy D ; Völzke, Henry ; Watkins, Hugh ; Wilson, James ; Groop, Leif C ; Haritunians, Talin ; Hu, Frank B ; Kaplan, Robert C ; Metspalu, Andres ; North, Kari E ; Schlessinger, David ; Wareham, Nicholas J ; Hunter, David J ; O'Connell, Jeffrey R ; Strachan, David P ; Wichmann, H-Erich ; Borecki, Ingrid B ; van Duijn, Cornelia M ; Schadt, Eric E ; Thorsteinsdottir, Unnur ; Peltonen, Leena ; Uitterlinden, André G ; Visscher, Peter M ; Chatterjee, Nilanjan ; Loos, Ruth J F ; Boehnke, Michael ; McCarthy, Mark I ; Ingelsson, Erik ; Lindgren, Cecilia M ; Abecasis, Gonçalo R ; Stefansson, Kari ; Frayling, Timothy M ; Hirschhorn, Joel N. / Hundreds of variants clustered in genomic loci and biological pathways affect human height. In: Nature. 2010 ; Vol. 467, No. 7317. pp. 832-8.
Bibtex
@article{6b446c87394b4484a305f264c7a6d353,
title = "Hundreds of variants clustered in genomic loci and biological pathways affect human height",
abstract = "Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P ",
keywords = "Body Height, Chromosomes, Human, Pair 3, Genetic Loci, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Metabolic Networks and Pathways, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide",
author = "{Lango Allen}, Hana and Karol Estrada and Guillaume Lettre and Berndt, {Sonja I} and Weedon, {Michael N} and Fernando Rivadeneira and Willer, {Cristen J} and Jackson, {Anne U} and Sailaja Vedantam and Soumya Raychaudhuri and Teresa Ferreira and Wood, {Andrew R} and Weyant, {Robert J} and Segr{\`e}, {Ayellet V} and Speliotes, {Elizabeth K} and Eleanor Wheeler and Nicole Soranzo and Ju-Hyun Park and Jian Yang and Daniel Gudbjartsson and Heard-Costa, {Nancy L} and Randall, {Joshua C} and Lu Qi and {Vernon Smith}, Albert and Reedik M{\"a}gi and Tomi Pastinen and Liming Liang and Heid, {Iris M} and Jian'an Luan and Gudmar Thorleifsson and Winkler, {Thomas W} and Goddard, {Michael E} and {Sin Lo}, Ken and Cameron Palmer and Tsegaselassie Workalemahu and Aulchenko, {Yurii S} and Asa Johansson and Zillikens, {M Carola} and Feitosa, {Mary F} and T{\~o}nu Esko and Toby Johnson and Shamika Ketkar and Peter Kraft and Massimo Mangino and Inga Prokopenko and Devin Absher and Eva Albrecht and Florian Ernst and Glazer, {Nicole L} and Caroline Hayward and Jouke-Jan Hottenga and Jacobs, {Kevin B} and Knowles, {Joshua W} and Zolt{\'a}n Kutalik and Monda, {Keri L} and Ozren Polasek and Michael Preuss and Rayner, {Nigel W} and Robertson, {Neil R} and Valgerdur Steinthorsdottir and Tyrer, {Jonathan P} and Voight, {Benjamin F} and Fredrik Wiklund and Jianfeng Xu and Zhao, {Jing Hua} and Nyholt, {Dale R} and Niina Pellikka and Markus Perola and Perry, {John R B} and Ida Surakka and Mari-Liis Tammesoo and Altmaier, {Elizabeth L} and Najaf Amin and Thor Aspelund and Tushar Bhangale and Gabrielle Boucher and Chasman, {Daniel I} and Constance Chen and Lachlan Coin and Cooper, {Matthew N} and Dixon, {Anna L} and Quince Gibson and Elin Grundberg and Ke Hao and {Juhani Junttila}, M and Kaplan, {Lee M} and Johannes Kettunen and K{\"o}nig, {Inke R} and Tony Kwan and Lawrence, {Robert W} and Levinson, {Douglas F} and Mattias Lorentzon and Barbara McKnight and Morris, {Andrew P} and Martina M{\"u}ller and {Suh Ngwa}, Julius and Shaun Purcell and Suzanne Rafelt and Salem, {Rany M} and Erika Salvi and Serena Sanna and Jianxin Shi and Ulla Sovio and Thompson, {John R} and Turchin, {Michael C} and Liesbeth Vandenput and Verlaan, {Dominique J} and Veronique Vitart and White, {Charles C} and Andreas Ziegler and Peter Almgren and Balmforth, {Anthony J} and Harry Campbell and Lorena Citterio and {De Grandi}, Alessandro and Anna Dominiczak and Jubao Duan and Paul Elliott and Roberto Elosua and Eriksson, {Johan G} and Freimer, {Nelson B} and Geus, {Eco J C} and Nicola Glorioso and Shen Haiqing and Anna-Liisa Hartikainen and Havulinna, {Aki S} and Hicks, {Andrew A} and Jennie Hui and Wilmar Igl and Thomas Illig and Antti Jula and Eero Kajantie and {Oskari Kilpel{\"a}inen}, Tuomas and Markku Koiranen and Ivana Kolcic and Seppo Koskinen and Peter Kovacs and Jaana Laitinen and Jianjun Liu and Marja-Liisa Lokki and Ana Marusic and Andrea Maschio and Thomas Meitinger and Antonella Mulas and Guillaume Par{\'e} and Parker, {Alex N} and Peden, {John F} and Astrid Petersmann and Irene Pichler and Pietil{\"a}inen, {Kirsi H} and Anneli Pouta and Martin Ridderstr{\aa}le and Rotter, {Jerome I} and Sambrook, {Jennifer G} and Sanders, {Alan R} and Schmidt, {Carsten Oliver} and Juha Sinisalo and Smit, {Jan H} and Stringham, {Heather M} and {Bragi Walters}, G and Elisabeth Widen and Wild, {Sarah H} and Gonneke Willemsen and Laura Zagato and Lina Zgaga and Paavo Zitting and Helene Alavere and Martin Farrall and McArdle, {Wendy L} and Mari Nelis and Peters, {Marjolein J} and Samuli Ripatti and {van Meurs}, {Joyce B J} and Aben, {Katja K} and Ardlie, {Kristin G} and Beckmann, {Jacques S} and Beilby, {John P} and Bergman, {Richard N} and Sven Bergmann and Collins, {Francis S} and Daniele Cusi and {den Heijer}, Martin and Gudny Eiriksdottir and Gejman, {Pablo V} and Hall, {Alistair S} and Anders Hamsten and Huikuri, {Heikki V} and Carlos Iribarren and Mika K{\"a}h{\"o}nen and Jaakko Kaprio and Sekar Kathiresan and Lambertus Kiemeney and Thomas Kocher and Launer, {Lenore J} and Terho Lehtim{\"a}ki and Olle Melander and Mosley, {Tom H} and Musk, {Arthur W} and Nieminen, {Markku S} and O'Donnell, {Christopher J} and Claes Ohlsson and Ben Oostra and Palmer, {Lyle J} and Olli Raitakari and Ridker, {Paul M} and Rioux, {John D} and Aila Rissanen and Carlo Rivolta and Heribert Schunkert and Shuldiner, {Alan R} and Siscovick, {David S} and Michael Stumvoll and Anke T{\"o}njes and Jaakko Tuomilehto and {van Ommen}, Gert-Jan and Jorma Viikari and Heath, {Andrew C} and Martin, {Nicholas G} and Montgomery, {Grant W} and Province, {Michael A} and Manfred Kayser and Arnold, {Alice M} and Atwood, {Larry D} and Eric Boerwinkle and Chanock, {Stephen J} and Panos Deloukas and Christian Gieger and Henrik Gr{\"o}nberg and Per Hall and Hattersley, {Andrew T} and Christian Hengstenberg and Wolfgang Hoffman and Lathrop, {G Mark} and Veikko Salomaa and Stefan Schreiber and Manuela Uda and Dawn Waterworth and Wright, {Alan F} and Assimes, {Themistocles L} and In{\^e}s Barroso and Albert Hofman and Mohlke, {Karen L} and Boomsma, {Dorret I} and Caulfield, {Mark J} and Cupples, {L Adrienne} and Jeanette Erdmann and Fox, {Caroline S} and Vilmundur Gudnason and Ulf Gyllensten and Harris, {Tamara B} and Hayes, {Richard B} and Marjo-Riitta Jarvelin and Vincent Mooser and Munroe, {Patricia B} and Ouwehand, {Willem H} and Penninx, {Brenda W} and Pramstaller, {Peter P} and Thomas Quertermous and Igor Rudan and Samani, {Nilesh J} and Spector, {Timothy D} and Henry V{\"o}lzke and Hugh Watkins and James Wilson and Groop, {Leif C} and Talin Haritunians and Hu, {Frank B} and Kaplan, {Robert C} and Andres Metspalu and North, {Kari E} and David Schlessinger and Wareham, {Nicholas J} and Hunter, {David J} and O'Connell, {Jeffrey R} and Strachan, {David P} and H-Erich Wichmann and Borecki, {Ingrid B} and {van Duijn}, {Cornelia M} and Schadt, {Eric E} and Unnur Thorsteinsdottir and Leena Peltonen and Uitterlinden, {Andr{\'e} G} and Visscher, {Peter M} and Nilanjan Chatterjee and Loos, {Ruth J F} and Michael Boehnke and McCarthy, {Mark I} and Erik Ingelsson and Lindgren, {Cecilia M} and Abecasis, {Gon{\c c}alo R} and Kari Stefansson and Frayling, {Timothy M} and Hirschhorn, {Joel N}",
year = "2010",
month = oct,
day = "14",
doi = "10.1038/nature09410",
language = "English",
volume = "467",
pages = "832--8",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7317",
}
RIS
TY - JOUR
T1 - Hundreds of variants clustered in genomic loci and biological pathways affect human height
AU - Lango Allen, Hana
AU - Estrada, Karol
AU - Lettre, Guillaume
AU - Berndt, Sonja I
AU - Weedon, Michael N
AU - Rivadeneira, Fernando
AU - Willer, Cristen J
AU - Jackson, Anne U
AU - Vedantam, Sailaja
AU - Raychaudhuri, Soumya
AU - Ferreira, Teresa
AU - Wood, Andrew R
AU - Weyant, Robert J
AU - Segrè, Ayellet V
AU - Speliotes, Elizabeth K
AU - Wheeler, Eleanor
AU - Soranzo, Nicole
AU - Park, Ju-Hyun
AU - Yang, Jian
AU - Gudbjartsson, Daniel
AU - Heard-Costa, Nancy L
AU - Randall, Joshua C
AU - Qi, Lu
AU - Vernon Smith, Albert
AU - Mägi, Reedik
AU - Pastinen, Tomi
AU - Liang, Liming
AU - Heid, Iris M
AU - Luan, Jian'an
AU - Thorleifsson, Gudmar
AU - Winkler, Thomas W
AU - Goddard, Michael E
AU - Sin Lo, Ken
AU - Palmer, Cameron
AU - Workalemahu, Tsegaselassie
AU - Aulchenko, Yurii S
AU - Johansson, Asa
AU - Zillikens, M Carola
AU - Feitosa, Mary F
AU - Esko, Tõnu
AU - Johnson, Toby
AU - Ketkar, Shamika
AU - Kraft, Peter
AU - Mangino, Massimo
AU - Prokopenko, Inga
AU - Absher, Devin
AU - Albrecht, Eva
AU - Ernst, Florian
AU - Glazer, Nicole L
AU - Hayward, Caroline
AU - Hottenga, Jouke-Jan
AU - Jacobs, Kevin B
AU - Knowles, Joshua W
AU - Kutalik, Zoltán
AU - Monda, Keri L
AU - Polasek, Ozren
AU - Preuss, Michael
AU - Rayner, Nigel W
AU - Robertson, Neil R
AU - Steinthorsdottir, Valgerdur
AU - Tyrer, Jonathan P
AU - Voight, Benjamin F
AU - Wiklund, Fredrik
AU - Xu, Jianfeng
AU - Zhao, Jing Hua
AU - Nyholt, Dale R
AU - Pellikka, Niina
AU - Perola, Markus
AU - Perry, John R B
AU - Surakka, Ida
AU - Tammesoo, Mari-Liis
AU - Altmaier, Elizabeth L
AU - Amin, Najaf
AU - Aspelund, Thor
AU - Bhangale, Tushar
AU - Boucher, Gabrielle
AU - Chasman, Daniel I
AU - Chen, Constance
AU - Coin, Lachlan
AU - Cooper, Matthew N
AU - Dixon, Anna L
AU - Gibson, Quince
AU - Grundberg, Elin
AU - Hao, Ke
AU - Juhani Junttila, M
AU - Kaplan, Lee M
AU - Kettunen, Johannes
AU - König, Inke R
AU - Kwan, Tony
AU - Lawrence, Robert W
AU - Levinson, Douglas F
AU - Lorentzon, Mattias
AU - McKnight, Barbara
AU - Morris, Andrew P
AU - Müller, Martina
AU - Suh Ngwa, Julius
AU - Purcell, Shaun
AU - Rafelt, Suzanne
AU - Salem, Rany M
AU - Salvi, Erika
AU - Sanna, Serena
AU - Shi, Jianxin
AU - Sovio, Ulla
AU - Thompson, John R
AU - Turchin, Michael C
AU - Vandenput, Liesbeth
AU - Verlaan, Dominique J
AU - Vitart, Veronique
AU - White, Charles C
AU - Ziegler, Andreas
AU - Almgren, Peter
AU - Balmforth, Anthony J
AU - Campbell, Harry
AU - Citterio, Lorena
AU - De Grandi, Alessandro
AU - Dominiczak, Anna
AU - Duan, Jubao
AU - Elliott, Paul
AU - Elosua, Roberto
AU - Eriksson, Johan G
AU - Freimer, Nelson B
AU - Geus, Eco J C
AU - Glorioso, Nicola
AU - Haiqing, Shen
AU - Hartikainen, Anna-Liisa
AU - Havulinna, Aki S
AU - Hicks, Andrew A
AU - Hui, Jennie
AU - Igl, Wilmar
AU - Illig, Thomas
AU - Jula, Antti
AU - Kajantie, Eero
AU - Oskari Kilpeläinen, Tuomas
AU - Koiranen, Markku
AU - Kolcic, Ivana
AU - Koskinen, Seppo
AU - Kovacs, Peter
AU - Laitinen, Jaana
AU - Liu, Jianjun
AU - Lokki, Marja-Liisa
AU - Marusic, Ana
AU - Maschio, Andrea
AU - Meitinger, Thomas
AU - Mulas, Antonella
AU - Paré, Guillaume
AU - Parker, Alex N
AU - Peden, John F
AU - Petersmann, Astrid
AU - Pichler, Irene
AU - Pietiläinen, Kirsi H
AU - Pouta, Anneli
AU - Ridderstråle, Martin
AU - Rotter, Jerome I
AU - Sambrook, Jennifer G
AU - Sanders, Alan R
AU - Schmidt, Carsten Oliver
AU - Sinisalo, Juha
AU - Smit, Jan H
AU - Stringham, Heather M
AU - Bragi Walters, G
AU - Widen, Elisabeth
AU - Wild, Sarah H
AU - Willemsen, Gonneke
AU - Zagato, Laura
AU - Zgaga, Lina
AU - Zitting, Paavo
AU - Alavere, Helene
AU - Farrall, Martin
AU - McArdle, Wendy L
AU - Nelis, Mari
AU - Peters, Marjolein J
AU - Ripatti, Samuli
AU - van Meurs, Joyce B J
AU - Aben, Katja K
AU - Ardlie, Kristin G
AU - Beckmann, Jacques S
AU - Beilby, John P
AU - Bergman, Richard N
AU - Bergmann, Sven
AU - Collins, Francis S
AU - Cusi, Daniele
AU - den Heijer, Martin
AU - Eiriksdottir, Gudny
AU - Gejman, Pablo V
AU - Hall, Alistair S
AU - Hamsten, Anders
AU - Huikuri, Heikki V
AU - Iribarren, Carlos
AU - Kähönen, Mika
AU - Kaprio, Jaakko
AU - Kathiresan, Sekar
AU - Kiemeney, Lambertus
AU - Kocher, Thomas
AU - Launer, Lenore J
AU - Lehtimäki, Terho
AU - Melander, Olle
AU - Mosley, Tom H
AU - Musk, Arthur W
AU - Nieminen, Markku S
AU - O'Donnell, Christopher J
AU - Ohlsson, Claes
AU - Oostra, Ben
AU - Palmer, Lyle J
AU - Raitakari, Olli
AU - Ridker, Paul M
AU - Rioux, John D
AU - Rissanen, Aila
AU - Rivolta, Carlo
AU - Schunkert, Heribert
AU - Shuldiner, Alan R
AU - Siscovick, David S
AU - Stumvoll, Michael
AU - Tönjes, Anke
AU - Tuomilehto, Jaakko
AU - van Ommen, Gert-Jan
AU - Viikari, Jorma
AU - Heath, Andrew C
AU - Martin, Nicholas G
AU - Montgomery, Grant W
AU - Province, Michael A
AU - Kayser, Manfred
AU - Arnold, Alice M
AU - Atwood, Larry D
AU - Boerwinkle, Eric
AU - Chanock, Stephen J
AU - Deloukas, Panos
AU - Gieger, Christian
AU - Grönberg, Henrik
AU - Hall, Per
AU - Hattersley, Andrew T
AU - Hengstenberg, Christian
AU - Hoffman, Wolfgang
AU - Lathrop, G Mark
AU - Salomaa, Veikko
AU - Schreiber, Stefan
AU - Uda, Manuela
AU - Waterworth, Dawn
AU - Wright, Alan F
AU - Assimes, Themistocles L
AU - Barroso, Inês
AU - Hofman, Albert
AU - Mohlke, Karen L
AU - Boomsma, Dorret I
AU - Caulfield, Mark J
AU - Cupples, L Adrienne
AU - Erdmann, Jeanette
AU - Fox, Caroline S
AU - Gudnason, Vilmundur
AU - Gyllensten, Ulf
AU - Harris, Tamara B
AU - Hayes, Richard B
AU - Jarvelin, Marjo-Riitta
AU - Mooser, Vincent
AU - Munroe, Patricia B
AU - Ouwehand, Willem H
AU - Penninx, Brenda W
AU - Pramstaller, Peter P
AU - Quertermous, Thomas
AU - Rudan, Igor
AU - Samani, Nilesh J
AU - Spector, Timothy D
AU - Völzke, Henry
AU - Watkins, Hugh
AU - Wilson, James
AU - Groop, Leif C
AU - Haritunians, Talin
AU - Hu, Frank B
AU - Kaplan, Robert C
AU - Metspalu, Andres
AU - North, Kari E
AU - Schlessinger, David
AU - Wareham, Nicholas J
AU - Hunter, David J
AU - O'Connell, Jeffrey R
AU - Strachan, David P
AU - Wichmann, H-Erich
AU - Borecki, Ingrid B
AU - van Duijn, Cornelia M
AU - Schadt, Eric E
AU - Thorsteinsdottir, Unnur
AU - Peltonen, Leena
AU - Uitterlinden, André G
AU - Visscher, Peter M
AU - Chatterjee, Nilanjan
AU - Loos, Ruth J F
AU - Boehnke, Michael
AU - McCarthy, Mark I
AU - Ingelsson, Erik
AU - Lindgren, Cecilia M
AU - Abecasis, Gonçalo R
AU - Stefansson, Kari
AU - Frayling, Timothy M
AU - Hirschhorn, Joel N
PY - 2010/10/14
Y1 - 2010/10/14
N2 - Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P
AB - Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P
KW - Body Height
KW - Chromosomes, Human, Pair 3
KW - Genetic Loci
KW - Genetic Predisposition to Disease
KW - Genome, Human
KW - Genome-Wide Association Study
KW - Humans
KW - Metabolic Networks and Pathways
KW - Multifactorial Inheritance
KW - Phenotype
KW - Polymorphism, Single Nucleotide
U2 - 10.1038/nature09410
DO - 10.1038/nature09410
M3 - Journal article
C2 - 20881960
VL - 467
SP - 832
EP - 838
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7317
ER -
