GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion

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GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. / Cani, Patrice D; Holst, Jens Juul; Drucker, Daniel J; Delzenne, Nathalie M; Thorens, Bernard; Burcelin, Rémy; Knauf, Claude.

In: Molecular and Cellular Endocrinology, Vol. 276, No. 1-2, 30.09.2007, p. 18-23.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cani, PD, Holst, JJ, Drucker, DJ, Delzenne, NM, Thorens, B, Burcelin, R & Knauf, C 2007, 'GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion', Molecular and Cellular Endocrinology, vol. 276, no. 1-2, pp. 18-23. https://doi.org/10.1016/j.mce.2007.06.003

APA

Cani, P. D., Holst, J. J., Drucker, D. J., Delzenne, N. M., Thorens, B., Burcelin, R., & Knauf, C. (2007). GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Molecular and Cellular Endocrinology, 276(1-2), 18-23. https://doi.org/10.1016/j.mce.2007.06.003

Vancouver

Cani PD, Holst JJ, Drucker DJ, Delzenne NM, Thorens B, Burcelin R et al. GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Molecular and Cellular Endocrinology. 2007 Sep 30;276(1-2):18-23. https://doi.org/10.1016/j.mce.2007.06.003

Author

Cani, Patrice D ; Holst, Jens Juul ; Drucker, Daniel J ; Delzenne, Nathalie M ; Thorens, Bernard ; Burcelin, Rémy ; Knauf, Claude. / GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. In: Molecular and Cellular Endocrinology. 2007 ; Vol. 276, No. 1-2. pp. 18-23.

Bibtex

@article{3e6a9a7ef9e64cf183bb31e2330df7f9,
title = "GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion",
abstract = "Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins secreted in response to oral glucose ingestion by intestinal L and K cells, respectively. The molecular mechanisms responsible for intestinal cell glucose sensing are unknown but could be related to those described for beta-cells, brain and hepatoportal sensors. We determined the role of GLUT2, GLP-1 or GIP receptors in glucose-induced incretins secretion, in the corresponding knockout mice. GLP-1 secretion was reduced in all mutant mice, while GIP secretion did not require GLUT2. Intestinal GLP-1 content was reduced only in GIP and GLUT2 receptors knockout mice suggesting that this impairment could contribute to the phenotype. Intestinal GIP content was similar in all mice studied. Furthermore, the impaired incretins secretion was associated with a reduced glucose-stimulated insulin secretion and an impaired glucose tolerance in all mice. In conclusion, both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2.",
keywords = "Animals, Gastric Inhibitory Polypeptide, Glucagon-Like Peptide 1, Glucose, Glucose Intolerance, Glucose Tolerance Test, Glucose Transporter Type 2, Intestines, Mice, Mice, Knockout, Models, Biological, Portal System, Receptors, Gastrointestinal Hormone, Receptors, Glucagon",
author = "Cani, {Patrice D} and Holst, {Jens Juul} and Drucker, {Daniel J} and Delzenne, {Nathalie M} and Bernard Thorens and R{\'e}my Burcelin and Claude Knauf",
year = "2007",
month = sep,
day = "30",
doi = "10.1016/j.mce.2007.06.003",
language = "English",
volume = "276",
pages = "18--23",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion

AU - Cani, Patrice D

AU - Holst, Jens Juul

AU - Drucker, Daniel J

AU - Delzenne, Nathalie M

AU - Thorens, Bernard

AU - Burcelin, Rémy

AU - Knauf, Claude

PY - 2007/9/30

Y1 - 2007/9/30

N2 - Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins secreted in response to oral glucose ingestion by intestinal L and K cells, respectively. The molecular mechanisms responsible for intestinal cell glucose sensing are unknown but could be related to those described for beta-cells, brain and hepatoportal sensors. We determined the role of GLUT2, GLP-1 or GIP receptors in glucose-induced incretins secretion, in the corresponding knockout mice. GLP-1 secretion was reduced in all mutant mice, while GIP secretion did not require GLUT2. Intestinal GLP-1 content was reduced only in GIP and GLUT2 receptors knockout mice suggesting that this impairment could contribute to the phenotype. Intestinal GIP content was similar in all mice studied. Furthermore, the impaired incretins secretion was associated with a reduced glucose-stimulated insulin secretion and an impaired glucose tolerance in all mice. In conclusion, both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2.

AB - Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins secreted in response to oral glucose ingestion by intestinal L and K cells, respectively. The molecular mechanisms responsible for intestinal cell glucose sensing are unknown but could be related to those described for beta-cells, brain and hepatoportal sensors. We determined the role of GLUT2, GLP-1 or GIP receptors in glucose-induced incretins secretion, in the corresponding knockout mice. GLP-1 secretion was reduced in all mutant mice, while GIP secretion did not require GLUT2. Intestinal GLP-1 content was reduced only in GIP and GLUT2 receptors knockout mice suggesting that this impairment could contribute to the phenotype. Intestinal GIP content was similar in all mice studied. Furthermore, the impaired incretins secretion was associated with a reduced glucose-stimulated insulin secretion and an impaired glucose tolerance in all mice. In conclusion, both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2.

KW - Animals

KW - Gastric Inhibitory Polypeptide

KW - Glucagon-Like Peptide 1

KW - Glucose

KW - Glucose Intolerance

KW - Glucose Tolerance Test

KW - Glucose Transporter Type 2

KW - Intestines

KW - Mice

KW - Mice, Knockout

KW - Models, Biological

KW - Portal System

KW - Receptors, Gastrointestinal Hormone

KW - Receptors, Glucagon

U2 - 10.1016/j.mce.2007.06.003

DO - 10.1016/j.mce.2007.06.003

M3 - Journal article

C2 - 17681422

VL - 276

SP - 18

EP - 23

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

IS - 1-2

ER -

ID: 132049904