Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning

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Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning. / Thymann, Thomas; Le Huërou-Luron, I; Petersen, Y M; Hedemann, Mette Skou; Elinf, J; Jensen, B B; Holst, Jens Juul; Hartmann, Bolette; Sangild, Per Torp.

In: Journal of Animal Science, Vol. 92, No. 5, 2014, p. 2070-2079.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Thymann, T, Le Huërou-Luron, I, Petersen, YM, Hedemann, MS, Elinf, J, Jensen, BB, Holst, JJ, Hartmann, B & Sangild, PT 2014, 'Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning', Journal of Animal Science, vol. 92, no. 5, pp. 2070-2079. https://doi.org/10.2527/jas.2013-7015

APA

Thymann, T., Le Huërou-Luron, I., Petersen, Y. M., Hedemann, M. S., Elinf, J., Jensen, B. B., ... Sangild, P. T. (2014). Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning. Journal of Animal Science, 92(5), 2070-2079. https://doi.org/10.2527/jas.2013-7015

Vancouver

Thymann T, Le Huërou-Luron I, Petersen YM, Hedemann MS, Elinf J, Jensen BB et al. Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning. Journal of Animal Science. 2014;92(5):2070-2079. https://doi.org/10.2527/jas.2013-7015

Author

Thymann, Thomas ; Le Huërou-Luron, I ; Petersen, Y M ; Hedemann, Mette Skou ; Elinf, J ; Jensen, B B ; Holst, Jens Juul ; Hartmann, Bolette ; Sangild, Per Torp. / Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning. In: Journal of Animal Science. 2014 ; Vol. 92, No. 5. pp. 2070-2079.

Bibtex

@article{c96902fec5e94e55a045b2b3d4e4a49d,
title = "Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning",
abstract = "Transition from sow's milk to solid feed is associated with intestinal atrophy and diarrhea. We hypothesized that the intestinotrophic hormone glucagon-like peptide 2 (GLP-2) would induce a dose- and health status-dependent effect on gut adaptation. In Exp. 1, weaned pigs (average BW at weaning 4.98 ± 0.18 kg) were kept in a high-sanitary environment and injected with saline or short-acting GLP-2 (80 μg/(kg BW·12 h); n = 8). Under these conditions, there was no diarrhea and GLP-2 did not improve gastrointestinal structure or function. In Exp. 2, weaned pigs (average BW at weaning 6.68 ± 0.27 kg) were kept in a low-sanitary environment, leading to weaning diarrhea, and injected with saline or short-acting GLP-2 (200 µg/(kg BW·12 h); n = 11). Treatment with GLP-2 increased goblet cell density (P 20,000 pmol/L) and Exp. 2 (increases to 20,000 pmol/L for a few hours each day) while they were in the supraphysiological range in Exp. 1 (50-200 pmol/L). In conclusion, GLP-2 may improve gut structure and function in weanling pigs. However, the effects may be significant only under conditions of diarrhea and if GLP-2 exposure time is extended using long-acting analogues.",
author = "Thomas Thymann and {Le Hu{\"e}rou-Luron}, I and Petersen, {Y M} and Hedemann, {Mette Skou} and J Elinf and Jensen, {B B} and Holst, {Jens Juul} and Bolette Hartmann and Sangild, {Per Torp}",
note = "CURIS 2014 NEXS 128",
year = "2014",
doi = "10.2527/jas.2013-7015",
language = "English",
volume = "92",
pages = "2070--2079",
journal = "Journal of Animal Science",
issn = "0021-8812",
publisher = "American Society of Animal Science",
number = "5",

}

RIS

TY - JOUR

T1 - Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning

AU - Thymann, Thomas

AU - Le Huërou-Luron, I

AU - Petersen, Y M

AU - Hedemann, Mette Skou

AU - Elinf, J

AU - Jensen, B B

AU - Holst, Jens Juul

AU - Hartmann, Bolette

AU - Sangild, Per Torp

N1 - CURIS 2014 NEXS 128

PY - 2014

Y1 - 2014

N2 - Transition from sow's milk to solid feed is associated with intestinal atrophy and diarrhea. We hypothesized that the intestinotrophic hormone glucagon-like peptide 2 (GLP-2) would induce a dose- and health status-dependent effect on gut adaptation. In Exp. 1, weaned pigs (average BW at weaning 4.98 ± 0.18 kg) were kept in a high-sanitary environment and injected with saline or short-acting GLP-2 (80 μg/(kg BW·12 h); n = 8). Under these conditions, there was no diarrhea and GLP-2 did not improve gastrointestinal structure or function. In Exp. 2, weaned pigs (average BW at weaning 6.68 ± 0.27 kg) were kept in a low-sanitary environment, leading to weaning diarrhea, and injected with saline or short-acting GLP-2 (200 µg/(kg BW·12 h); n = 11). Treatment with GLP-2 increased goblet cell density (P 20,000 pmol/L) and Exp. 2 (increases to 20,000 pmol/L for a few hours each day) while they were in the supraphysiological range in Exp. 1 (50-200 pmol/L). In conclusion, GLP-2 may improve gut structure and function in weanling pigs. However, the effects may be significant only under conditions of diarrhea and if GLP-2 exposure time is extended using long-acting analogues.

AB - Transition from sow's milk to solid feed is associated with intestinal atrophy and diarrhea. We hypothesized that the intestinotrophic hormone glucagon-like peptide 2 (GLP-2) would induce a dose- and health status-dependent effect on gut adaptation. In Exp. 1, weaned pigs (average BW at weaning 4.98 ± 0.18 kg) were kept in a high-sanitary environment and injected with saline or short-acting GLP-2 (80 μg/(kg BW·12 h); n = 8). Under these conditions, there was no diarrhea and GLP-2 did not improve gastrointestinal structure or function. In Exp. 2, weaned pigs (average BW at weaning 6.68 ± 0.27 kg) were kept in a low-sanitary environment, leading to weaning diarrhea, and injected with saline or short-acting GLP-2 (200 µg/(kg BW·12 h); n = 11). Treatment with GLP-2 increased goblet cell density (P 20,000 pmol/L) and Exp. 2 (increases to 20,000 pmol/L for a few hours each day) while they were in the supraphysiological range in Exp. 1 (50-200 pmol/L). In conclusion, GLP-2 may improve gut structure and function in weanling pigs. However, the effects may be significant only under conditions of diarrhea and if GLP-2 exposure time is extended using long-acting analogues.

U2 - 10.2527/jas.2013-7015

DO - 10.2527/jas.2013-7015

M3 - Journal article

C2 - 24663206

VL - 92

SP - 2070

EP - 2079

JO - Journal of Animal Science

JF - Journal of Animal Science

SN - 0021-8812

IS - 5

ER -

ID: 109556497