Giant glial cell: new insight through mechanism-based modeling

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Giant glial cell: new insight through mechanism-based modeling. / Postnov, D E; Ryazanova, L S; Brazhe, Nadezda; Brazhe, Alexey; Maximov, G V; Mosekilde, Erik; Sosnovtseva, Olga.

In: Journal of Biological Physics, Vol. 34, No. 3-4, 01.08.2008, p. 441-57.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Postnov, DE, Ryazanova, LS, Brazhe, N, Brazhe, A, Maximov, GV, Mosekilde, E & Sosnovtseva, O 2008, 'Giant glial cell: new insight through mechanism-based modeling', Journal of Biological Physics, vol. 34, no. 3-4, pp. 441-57. https://doi.org/10.1007/s10867-008-9070-7

APA

Postnov, D. E., Ryazanova, L. S., Brazhe, N., Brazhe, A., Maximov, G. V., Mosekilde, E., & Sosnovtseva, O. (2008). Giant glial cell: new insight through mechanism-based modeling. Journal of Biological Physics, 34(3-4), 441-57. https://doi.org/10.1007/s10867-008-9070-7

Vancouver

Postnov DE, Ryazanova LS, Brazhe N, Brazhe A, Maximov GV, Mosekilde E et al. Giant glial cell: new insight through mechanism-based modeling. Journal of Biological Physics. 2008 Aug 1;34(3-4):441-57. https://doi.org/10.1007/s10867-008-9070-7

Author

Postnov, D E ; Ryazanova, L S ; Brazhe, Nadezda ; Brazhe, Alexey ; Maximov, G V ; Mosekilde, Erik ; Sosnovtseva, Olga. / Giant glial cell: new insight through mechanism-based modeling. In: Journal of Biological Physics. 2008 ; Vol. 34, No. 3-4. pp. 441-57.

Bibtex

@article{755431389f33475191004673d0ee1527,
title = "Giant glial cell: new insight through mechanism-based modeling",
abstract = "The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.",
author = "Postnov, {D E} and Ryazanova, {L S} and Nadezda Brazhe and Alexey Brazhe and Maximov, {G V} and Erik Mosekilde and Olga Sosnovtseva",
year = "2008",
month = aug,
day = "1",
doi = "10.1007/s10867-008-9070-7",
language = "English",
volume = "34",
pages = "441--57",
journal = "Journal of Biological Physics",
issn = "0092-0606",
publisher = "Springer",
number = "3-4",

}

RIS

TY - JOUR

T1 - Giant glial cell: new insight through mechanism-based modeling

AU - Postnov, D E

AU - Ryazanova, L S

AU - Brazhe, Nadezda

AU - Brazhe, Alexey

AU - Maximov, G V

AU - Mosekilde, Erik

AU - Sosnovtseva, Olga

PY - 2008/8/1

Y1 - 2008/8/1

N2 - The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.

AB - The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.

U2 - 10.1007/s10867-008-9070-7

DO - 10.1007/s10867-008-9070-7

M3 - Journal article

C2 - 19669488

VL - 34

SP - 441

EP - 457

JO - Journal of Biological Physics

JF - Journal of Biological Physics

SN - 0092-0606

IS - 3-4

ER -

ID: 33812338