Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes
Research output: Contribution to journal › Journal article › Research › peer-review
The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.
|Journal||International Journal of Obesity|
|Number of pages||6|
|Publication status||Published - 2007|
- Aged, Anthropometry, Blood Glucose, Body Constitution, Chromosomes, Human, Pair 11, DNA Mutational Analysis, Diabetes Mellitus, Type 2, Estrogen Receptor alpha, Female, Genetic Predisposition to Disease, Heat-Shock Proteins, Humans, Insulin, Linkage Disequilibrium, Lipids, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, Transcription Factors