Gastrointestinal regulatory peptides in familial adenomatous polyposis
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Gastrointestinal regulatory peptides in familial adenomatous polyposis. / Olsen, Peter Skov; Bülow, Steffen; Jørgensen, Per N.; Poulsen, Steen Seier; Nexø, Ebba.
In: Digestion, Vol. 46, No. 4, 01.01.1990, p. 228-232.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Gastrointestinal regulatory peptides in familial adenomatous polyposis
AU - Olsen, Peter Skov
AU - Bülow, Steffen
AU - Jørgensen, Per N.
AU - Poulsen, Steen Seier
AU - Nexø, Ebba
PY - 1990/1/1
Y1 - 1990/1/1
N2 - The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.
AB - The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.
KW - Duodenal polyps
KW - Familial adenomatous polyposis
KW - Regulatory peptides
UR - http://www.scopus.com/inward/record.url?scp=0025641543&partnerID=8YFLogxK
U2 - 10.1159/000200350
DO - 10.1159/000200350
M3 - Journal article
C2 - 2178136
AN - SCOPUS:0025641543
VL - 46
SP - 228
EP - 232
JO - Digestion
JF - Digestion
SN - 0012-2823
IS - 4
ER -
ID: 199324522