Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study

Research output: Contribution to journalJournal articlepeer-review

Standard

Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans : A pilot dose-ranging study. / Wolnerhanssen, Bettina K.; Drewe, Juergen; Verbeure, Wout; le Roux, Carel W.; Dellatorre-Teixeira, Ludmilla; Rehfeld, Jens F.; Holst, Jens J.; Hartmann, Bolette; Tack, Jan; Peterli, Ralph; Beglinger, Christoph; Meyer-Gerspach, Anne C.

In: Diabetes, Obesity and Metabolism, Vol. 23, No. 6, 2021, p. 1311-1321.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Wolnerhanssen, BK, Drewe, J, Verbeure, W, le Roux, CW, Dellatorre-Teixeira, L, Rehfeld, JF, Holst, JJ, Hartmann, B, Tack, J, Peterli, R, Beglinger, C & Meyer-Gerspach, AC 2021, 'Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study', Diabetes, Obesity and Metabolism, vol. 23, no. 6, pp. 1311-1321. https://doi.org/10.1111/dom.14342

APA

Wolnerhanssen, B. K., Drewe, J., Verbeure, W., le Roux, C. W., Dellatorre-Teixeira, L., Rehfeld, J. F., Holst, J. J., Hartmann, B., Tack, J., Peterli, R., Beglinger, C., & Meyer-Gerspach, A. C. (2021). Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study. Diabetes, Obesity and Metabolism, 23(6), 1311-1321. https://doi.org/10.1111/dom.14342

Vancouver

Wolnerhanssen BK, Drewe J, Verbeure W, le Roux CW, Dellatorre-Teixeira L, Rehfeld JF et al. Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study. Diabetes, Obesity and Metabolism. 2021;23(6):1311-1321. https://doi.org/10.1111/dom.14342

Author

Wolnerhanssen, Bettina K. ; Drewe, Juergen ; Verbeure, Wout ; le Roux, Carel W. ; Dellatorre-Teixeira, Ludmilla ; Rehfeld, Jens F. ; Holst, Jens J. ; Hartmann, Bolette ; Tack, Jan ; Peterli, Ralph ; Beglinger, Christoph ; Meyer-Gerspach, Anne C. / Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans : A pilot dose-ranging study. In: Diabetes, Obesity and Metabolism. 2021 ; Vol. 23, No. 6. pp. 1311-1321.

Bibtex

@article{d9e9e21d0f1c491b835273c0d1060ddb,
title = "Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study",
abstract = "Aim To determine whether a dose-dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon-like peptide-1 [aGLP-1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol.Materials and Methods Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with C-13-sodium acetate on four study days via a nasogastric tube in this randomized (active treatments), placebo-controlled, double-blind, cross-over trial. Blood samples and breath samples (C-13-sodium acetate method for measurement of gastric emptying [GE]) were taken at regular intervals, and sensations of appetite and gastrointestinal symptoms were rated.Results We found (a) a dose-dependent stimulation of CCK, aGLP-1 and PYY, and slowing of GE, (b) no effect on blood glucose, insulin, motilin, glucagon or glucose-dependent insulinotropic polypeptide, (c) no effect on blood lipids and uric acid, and (d) no abdominal pain, nausea or vomiting.Conclusions Solutions with 10 and 50 g of erythritol stimulated gut hormone release. Emptying of erythritol-containing solutions from the stomach was slower compared with placebo. There was no effect on plasma glucose, insulin, glucagon, blood lipids or uric acid. All doses were well tolerated.",
keywords = "appetite&#8208, related sensations, blood lipids, erythritol, gastric emptying, gastrointestinal symptoms, gut hormones, natural sweeteners, uric acid",
author = "Wolnerhanssen, {Bettina K.} and Juergen Drewe and Wout Verbeure and {le Roux}, {Carel W.} and Ludmilla Dellatorre-Teixeira and Rehfeld, {Jens F.} and Holst, {Jens J.} and Bolette Hartmann and Jan Tack and Ralph Peterli and Christoph Beglinger and Meyer-Gerspach, {Anne C.}",
year = "2021",
doi = "10.1111/dom.14342",
language = "English",
volume = "23",
pages = "1311--1321",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans

T2 - A pilot dose-ranging study

AU - Wolnerhanssen, Bettina K.

AU - Drewe, Juergen

AU - Verbeure, Wout

AU - le Roux, Carel W.

AU - Dellatorre-Teixeira, Ludmilla

AU - Rehfeld, Jens F.

AU - Holst, Jens J.

AU - Hartmann, Bolette

AU - Tack, Jan

AU - Peterli, Ralph

AU - Beglinger, Christoph

AU - Meyer-Gerspach, Anne C.

PY - 2021

Y1 - 2021

N2 - Aim To determine whether a dose-dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon-like peptide-1 [aGLP-1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol.Materials and Methods Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with C-13-sodium acetate on four study days via a nasogastric tube in this randomized (active treatments), placebo-controlled, double-blind, cross-over trial. Blood samples and breath samples (C-13-sodium acetate method for measurement of gastric emptying [GE]) were taken at regular intervals, and sensations of appetite and gastrointestinal symptoms were rated.Results We found (a) a dose-dependent stimulation of CCK, aGLP-1 and PYY, and slowing of GE, (b) no effect on blood glucose, insulin, motilin, glucagon or glucose-dependent insulinotropic polypeptide, (c) no effect on blood lipids and uric acid, and (d) no abdominal pain, nausea or vomiting.Conclusions Solutions with 10 and 50 g of erythritol stimulated gut hormone release. Emptying of erythritol-containing solutions from the stomach was slower compared with placebo. There was no effect on plasma glucose, insulin, glucagon, blood lipids or uric acid. All doses were well tolerated.

AB - Aim To determine whether a dose-dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon-like peptide-1 [aGLP-1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol.Materials and Methods Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with C-13-sodium acetate on four study days via a nasogastric tube in this randomized (active treatments), placebo-controlled, double-blind, cross-over trial. Blood samples and breath samples (C-13-sodium acetate method for measurement of gastric emptying [GE]) were taken at regular intervals, and sensations of appetite and gastrointestinal symptoms were rated.Results We found (a) a dose-dependent stimulation of CCK, aGLP-1 and PYY, and slowing of GE, (b) no effect on blood glucose, insulin, motilin, glucagon or glucose-dependent insulinotropic polypeptide, (c) no effect on blood lipids and uric acid, and (d) no abdominal pain, nausea or vomiting.Conclusions Solutions with 10 and 50 g of erythritol stimulated gut hormone release. Emptying of erythritol-containing solutions from the stomach was slower compared with placebo. There was no effect on plasma glucose, insulin, glucagon, blood lipids or uric acid. All doses were well tolerated.

KW - appetite&#8208

KW - related sensations

KW - blood lipids

KW - erythritol

KW - gastric emptying

KW - gastrointestinal symptoms

KW - gut hormones

KW - natural sweeteners

KW - uric acid

U2 - 10.1111/dom.14342

DO - 10.1111/dom.14342

M3 - Journal article

C2 - 33565706

VL - 23

SP - 1311

EP - 1321

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 6

ER -

ID: 258083478