Galanin: distribution and effect on contractile activity and release of vasoactive intestinal polypeptide from the isolated perfused porcine ileum

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Standard

Galanin : distribution and effect on contractile activity and release of vasoactive intestinal polypeptide from the isolated perfused porcine ileum. / Poulsen, Steen Seier; Holst, J J.

In: Digestion, Vol. 47, No. 4, 1990, p. 191-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS & Holst, JJ 1990, 'Galanin: distribution and effect on contractile activity and release of vasoactive intestinal polypeptide from the isolated perfused porcine ileum', Digestion, vol. 47, no. 4, pp. 191-9.

APA

Poulsen, S. S., & Holst, J. J. (1990). Galanin: distribution and effect on contractile activity and release of vasoactive intestinal polypeptide from the isolated perfused porcine ileum. Digestion, 47(4), 191-9.

Vancouver

Poulsen SS, Holst JJ. Galanin: distribution and effect on contractile activity and release of vasoactive intestinal polypeptide from the isolated perfused porcine ileum. Digestion. 1990;47(4):191-9.

Author

Poulsen, Steen Seier ; Holst, J J. / Galanin : distribution and effect on contractile activity and release of vasoactive intestinal polypeptide from the isolated perfused porcine ileum. In: Digestion. 1990 ; Vol. 47, No. 4. pp. 191-9.

Bibtex

@article{d5ed93d6d0e148cab42ddb52ca48dc59,
title = "Galanin: distribution and effect on contractile activity and release of vasoactive intestinal polypeptide from the isolated perfused porcine ileum",
abstract = "In the pig ileum galanin (GAL)-like immunoreactivity was identified in nerve cell bodies of the submucous plexus and in nerve fibers of the circular and longitudinal muscle layer. Infusion of 5.10(-10)-10(-8) M of GAL into the arterial line of the isolated perfused porcine ileum decreased the frequency of spontaneous phasic contractions in a dose-dependent manner. The frequency of phasic contractions during maximal inhibition by GAL 10(-8) M was 13 +/- 4% (mean +/- SE) of basal frequency (p less than 0.05). The recovery from inhibition by GAL 10(-8) M lasted 16 +/- 1 min. Tonic contractions were not observed in this experimental set-up, neither by standard perfused catheter manometry nor by measurement of cross-sectional area of an intraluminally located balloon. Infusion of GAL 10(-8) M decreased the venous release of vasoactive intestinal polypeptide to 80 +/- 8% of basal release (p less than 0.05). It is concluded that GAL may participate in the regulation of small intestinal motility in the pig.",
keywords = "Animals, Galanin, Gastrointestinal Motility, Ileum, Neuropeptides, Peptides, Perfusion, Radioimmunoassay, Swine, Vasoactive Intestinal Peptide",
author = "Poulsen, {Steen Seier} and Holst, {J J}",
year = "1990",
language = "English",
volume = "47",
pages = "191--9",
journal = "Digestion",
issn = "0012-2823",
publisher = "S Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Galanin

T2 - distribution and effect on contractile activity and release of vasoactive intestinal polypeptide from the isolated perfused porcine ileum

AU - Poulsen, Steen Seier

AU - Holst, J J

PY - 1990

Y1 - 1990

N2 - In the pig ileum galanin (GAL)-like immunoreactivity was identified in nerve cell bodies of the submucous plexus and in nerve fibers of the circular and longitudinal muscle layer. Infusion of 5.10(-10)-10(-8) M of GAL into the arterial line of the isolated perfused porcine ileum decreased the frequency of spontaneous phasic contractions in a dose-dependent manner. The frequency of phasic contractions during maximal inhibition by GAL 10(-8) M was 13 +/- 4% (mean +/- SE) of basal frequency (p less than 0.05). The recovery from inhibition by GAL 10(-8) M lasted 16 +/- 1 min. Tonic contractions were not observed in this experimental set-up, neither by standard perfused catheter manometry nor by measurement of cross-sectional area of an intraluminally located balloon. Infusion of GAL 10(-8) M decreased the venous release of vasoactive intestinal polypeptide to 80 +/- 8% of basal release (p less than 0.05). It is concluded that GAL may participate in the regulation of small intestinal motility in the pig.

AB - In the pig ileum galanin (GAL)-like immunoreactivity was identified in nerve cell bodies of the submucous plexus and in nerve fibers of the circular and longitudinal muscle layer. Infusion of 5.10(-10)-10(-8) M of GAL into the arterial line of the isolated perfused porcine ileum decreased the frequency of spontaneous phasic contractions in a dose-dependent manner. The frequency of phasic contractions during maximal inhibition by GAL 10(-8) M was 13 +/- 4% (mean +/- SE) of basal frequency (p less than 0.05). The recovery from inhibition by GAL 10(-8) M lasted 16 +/- 1 min. Tonic contractions were not observed in this experimental set-up, neither by standard perfused catheter manometry nor by measurement of cross-sectional area of an intraluminally located balloon. Infusion of GAL 10(-8) M decreased the venous release of vasoactive intestinal polypeptide to 80 +/- 8% of basal release (p less than 0.05). It is concluded that GAL may participate in the regulation of small intestinal motility in the pig.

KW - Animals

KW - Galanin

KW - Gastrointestinal Motility

KW - Ileum

KW - Neuropeptides

KW - Peptides

KW - Perfusion

KW - Radioimmunoassay

KW - Swine

KW - Vasoactive Intestinal Peptide

M3 - Journal article

C2 - 1712741

VL - 47

SP - 191

EP - 199

JO - Digestion

JF - Digestion

SN - 0012-2823

IS - 4

ER -

ID: 47488206