Fascicular heart blocks and risk of adverse cardiovascular outcomes

Fascicular heart blocks and risk of adverse cardiovascular outcomes: Results from a large primary care population

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Fascicular heart blocks and risk of adverse cardiovascular outcomes : Results from a large primary care population. / Nyholm, Benjamin Chris; Ghouse, Jonas; Lee, Christina Ji Young; Rasmussen, Peter Vibe; Pietersen, Adrian; Hansen, Steen Møller; Torp-Pedersen, Christian; Køber, Lars; Haunsø, Stig; Olesen, Morten Salling; Svendsen, Jesper Hastrup; Graff, Claus; Holst, Anders Gaarsdal; Nielsen, Jonas Bille; Skov, Morten Wagner.

In: Heart Rhythm, Vol. 19, No. 2, 2022, p. 252-259.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nyholm, BC, Ghouse, J, Lee, CJY, Rasmussen, PV, Pietersen, A, Hansen, SM, Torp-Pedersen, C, Køber, L, Haunsø, S, Olesen, MS, Svendsen, JH, Graff, C, Holst, AG, Nielsen, JB & Skov, MW 2022, 'Fascicular heart blocks and risk of adverse cardiovascular outcomes: Results from a large primary care population', Heart Rhythm, vol. 19, no. 2, pp. 252-259. https://doi.org/10.1016/j.hrthm.2021.09.041

APA

Nyholm, B. C., Ghouse, J., Lee, C. J. Y., Rasmussen, P. V., Pietersen, A., Hansen, S. M., Torp-Pedersen, C., Køber, L., Haunsø, S., Olesen, M. S., Svendsen, J. H., Graff, C., Holst, A. G., Nielsen, J. B., & Skov, M. W. (2022). Fascicular heart blocks and risk of adverse cardiovascular outcomes: Results from a large primary care population. Heart Rhythm, 19(2), 252-259. https://doi.org/10.1016/j.hrthm.2021.09.041

Vancouver

Nyholm BC, Ghouse J, Lee CJY, Rasmussen PV, Pietersen A, Hansen SM et al. Fascicular heart blocks and risk of adverse cardiovascular outcomes: Results from a large primary care population. Heart Rhythm. 2022;19(2):252-259. https://doi.org/10.1016/j.hrthm.2021.09.041

Author

Nyholm, Benjamin Chris ; Ghouse, Jonas ; Lee, Christina Ji Young ; Rasmussen, Peter Vibe ; Pietersen, Adrian ; Hansen, Steen Møller ; Torp-Pedersen, Christian ; Køber, Lars ; Haunsø, Stig ; Olesen, Morten Salling ; Svendsen, Jesper Hastrup ; Graff, Claus ; Holst, Anders Gaarsdal ; Nielsen, Jonas Bille ; Skov, Morten Wagner. / Fascicular heart blocks and risk of adverse cardiovascular outcomes : Results from a large primary care population. In: Heart Rhythm. 2022 ; Vol. 19, No. 2. pp. 252-259.

Bibtex

@article{5b44f1da1bd349f89cdd3ff06053e316,

title = "Fascicular heart blocks and risk of adverse cardiovascular outcomes: Results from a large primary care population",

abstract = "Background: Fascicular heart blocks can progress to complete heart blocks, but this risk has not been evaluated in a large general population. Objective: The purpose of this study was to investigate the association between various types of fascicular blocks diagnosed by electrocardiographic (ECG) readings and the risk of incident higher degree atrioventricular block (AVB), syncope, pacemaker implantation, and death. Methods: We studied primary care patients referred for ECG recording between 2001 and 2015. Cox regression models were used to estimate hazard ratios (HRs) as well as absolute risks of cardiovascular outcomes. Results: Of 358,958 primary care patients (median age 54 years; 55% women), 13,636 (3.8%) had any type of fascicular block. Patients were followed up to 15.9 years. We found increasing HRs of incident syncope, pacemaker implantation, and third-degree AVB with increasing complexity of fascicular block. Compared with no block, isolated left anterior fascicular block (LAFB) was associated with 0%–2% increased 10-year risk of developing third-degree AVB (HR 1.6; 95% confidence interval [CI] 1.25–2.05), whereas right bundle branch block combined with LAFB and first-degree AVB was associated with up to 23% increased 10-year risk (HR 11.0; 95% CI 7.7–15.7), depending on age and sex group. Except for left posterior fascicular block (HR 2.09; 95% CI 1.87–2.32), we did not find any relevant associations between fascicular block and death. Conclusion: We found that higher degrees of fascicular blocks were associated with increasing risk of syncope, pacemaker implantation, and complete heart block, but the association with death was negligible.",

keywords = "Complete heart block, Electrocardiography, Fascicular heart block, Pacemaker implantation, Risk prediction",

author = "Nyholm, {Benjamin Chris} and Jonas Ghouse and Lee, {Christina Ji Young} and Rasmussen, {Peter Vibe} and Adrian Pietersen and Hansen, {Steen M{\o}ller} and Christian Torp-Pedersen and Lars K{\o}ber and Stig Hauns{\o} and Olesen, {Morten Salling} and Svendsen, {Jesper Hastrup} and Claus Graff and Holst, {Anders Gaarsdal} and Nielsen, {Jonas Bille} and Skov, {Morten Wagner}",

note = "Publisher Copyright: {\textcopyright} 2021 Heart Rhythm Society",

year = "2022",

doi = "10.1016/j.hrthm.2021.09.041",

language = "English",

volume = "19",

pages = "252--259",

journal = "Heart Rhythm",

issn = "1547-5271",

publisher = "Elsevier",

number = "2",

}

RIS

TY - JOUR

T1 - Fascicular heart blocks and risk of adverse cardiovascular outcomes

T2 - Results from a large primary care population

AU - Nyholm, Benjamin Chris

AU - Ghouse, Jonas

AU - Lee, Christina Ji Young

AU - Rasmussen, Peter Vibe

AU - Pietersen, Adrian

AU - Hansen, Steen Møller

AU - Torp-Pedersen, Christian

AU - Køber, Lars

AU - Haunsø, Stig

AU - Olesen, Morten Salling

AU - Svendsen, Jesper Hastrup

AU - Graff, Claus

AU - Holst, Anders Gaarsdal

AU - Nielsen, Jonas Bille

AU - Skov, Morten Wagner

PY - 2022

Y1 - 2022

N2 - Background: Fascicular heart blocks can progress to complete heart blocks, but this risk has not been evaluated in a large general population. Objective: The purpose of this study was to investigate the association between various types of fascicular blocks diagnosed by electrocardiographic (ECG) readings and the risk of incident higher degree atrioventricular block (AVB), syncope, pacemaker implantation, and death. Methods: We studied primary care patients referred for ECG recording between 2001 and 2015. Cox regression models were used to estimate hazard ratios (HRs) as well as absolute risks of cardiovascular outcomes. Results: Of 358,958 primary care patients (median age 54 years; 55% women), 13,636 (3.8%) had any type of fascicular block. Patients were followed up to 15.9 years. We found increasing HRs of incident syncope, pacemaker implantation, and third-degree AVB with increasing complexity of fascicular block. Compared with no block, isolated left anterior fascicular block (LAFB) was associated with 0%–2% increased 10-year risk of developing third-degree AVB (HR 1.6; 95% confidence interval [CI] 1.25–2.05), whereas right bundle branch block combined with LAFB and first-degree AVB was associated with up to 23% increased 10-year risk (HR 11.0; 95% CI 7.7–15.7), depending on age and sex group. Except for left posterior fascicular block (HR 2.09; 95% CI 1.87–2.32), we did not find any relevant associations between fascicular block and death. Conclusion: We found that higher degrees of fascicular blocks were associated with increasing risk of syncope, pacemaker implantation, and complete heart block, but the association with death was negligible.

AB - Background: Fascicular heart blocks can progress to complete heart blocks, but this risk has not been evaluated in a large general population. Objective: The purpose of this study was to investigate the association between various types of fascicular blocks diagnosed by electrocardiographic (ECG) readings and the risk of incident higher degree atrioventricular block (AVB), syncope, pacemaker implantation, and death. Methods: We studied primary care patients referred for ECG recording between 2001 and 2015. Cox regression models were used to estimate hazard ratios (HRs) as well as absolute risks of cardiovascular outcomes. Results: Of 358,958 primary care patients (median age 54 years; 55% women), 13,636 (3.8%) had any type of fascicular block. Patients were followed up to 15.9 years. We found increasing HRs of incident syncope, pacemaker implantation, and third-degree AVB with increasing complexity of fascicular block. Compared with no block, isolated left anterior fascicular block (LAFB) was associated with 0%–2% increased 10-year risk of developing third-degree AVB (HR 1.6; 95% confidence interval [CI] 1.25–2.05), whereas right bundle branch block combined with LAFB and first-degree AVB was associated with up to 23% increased 10-year risk (HR 11.0; 95% CI 7.7–15.7), depending on age and sex group. Except for left posterior fascicular block (HR 2.09; 95% CI 1.87–2.32), we did not find any relevant associations between fascicular block and death. Conclusion: We found that higher degrees of fascicular blocks were associated with increasing risk of syncope, pacemaker implantation, and complete heart block, but the association with death was negligible.

KW - Complete heart block

KW - Electrocardiography

KW - Fascicular heart block

KW - Pacemaker implantation

KW - Risk prediction

U2 - 10.1016/j.hrthm.2021.09.041

DO - 10.1016/j.hrthm.2021.09.041

M3 - Journal article

C2 - 34673253

AN - SCOPUS:85118526253

VL - 19

SP - 252

EP - 259

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 2

ER -

ID: 286014669

Department of Biomedical Sciences