Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes

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Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes. / Scheede-Bergdahl, Celena; Bergdahl, Andreas; Schjerling, Peter; Qvortrup, Klaus; Koskinen, Satu O; Dela, Flemming.

In: Diabetes and Vascular Disease Research, Vol. 11, No. 5, 04.06.2014, p. 324-334.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Scheede-Bergdahl, C, Bergdahl, A, Schjerling, P, Qvortrup, K, Koskinen, SO & Dela, F 2014, 'Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes', Diabetes and Vascular Disease Research, vol. 11, no. 5, pp. 324-334. https://doi.org/10.1177/1479164114535943

APA

Scheede-Bergdahl, C., Bergdahl, A., Schjerling, P., Qvortrup, K., Koskinen, S. O., & Dela, F. (2014). Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes. Diabetes and Vascular Disease Research, 11(5), 324-334. https://doi.org/10.1177/1479164114535943

Vancouver

Scheede-Bergdahl C, Bergdahl A, Schjerling P, Qvortrup K, Koskinen SO, Dela F. Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes. Diabetes and Vascular Disease Research. 2014 Jun 4;11(5):324-334. https://doi.org/10.1177/1479164114535943

Author

Scheede-Bergdahl, Celena ; Bergdahl, Andreas ; Schjerling, Peter ; Qvortrup, Klaus ; Koskinen, Satu O ; Dela, Flemming. / Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes. In: Diabetes and Vascular Disease Research. 2014 ; Vol. 11, No. 5. pp. 324-334.

Bibtex

@article{9feaaefcf5e74d4ab2aef9608530d54f,
title = "Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes",
abstract = "Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) play a critical role during vascular remodelling, in both health and disease. Impaired MMP regulation is associated with many diabetes-related complications. This study examined whether exercise-induced regulation of MMPs is maintained in the skeletal muscle of patients with uncomplicated type 2 diabetes (T2DM). Subjects [12 T2DM, 9 healthy control subjects (CON)] underwent 8 weeks of physical training. Messenger RNA (mRNA) was measured at baseline, during and after 8 weeks of training. Protein was measured pre- and post-training. At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. Our results indicate that exercise-induced stimulation of MMPs is preserved in skeletal muscle of patients with T2DM. This early stage of diabetes may provide an opportunity for intervention and prevention of complications.",
author = "Celena Scheede-Bergdahl and Andreas Bergdahl and Peter Schjerling and Klaus Qvortrup and Koskinen, {Satu O} and Flemming Dela",
note = "{\textcopyright} The Author(s) 2014.",
year = "2014",
month = jun,
day = "4",
doi = "10.1177/1479164114535943",
language = "English",
volume = "11",
pages = "324--334",
journal = "Diabetes and Vascular Disease Research",
issn = "1479-1641",
publisher = "SAGE Publications",
number = "5",

}

RIS

TY - JOUR

T1 - Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes

AU - Scheede-Bergdahl, Celena

AU - Bergdahl, Andreas

AU - Schjerling, Peter

AU - Qvortrup, Klaus

AU - Koskinen, Satu O

AU - Dela, Flemming

N1 - © The Author(s) 2014.

PY - 2014/6/4

Y1 - 2014/6/4

N2 - Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) play a critical role during vascular remodelling, in both health and disease. Impaired MMP regulation is associated with many diabetes-related complications. This study examined whether exercise-induced regulation of MMPs is maintained in the skeletal muscle of patients with uncomplicated type 2 diabetes (T2DM). Subjects [12 T2DM, 9 healthy control subjects (CON)] underwent 8 weeks of physical training. Messenger RNA (mRNA) was measured at baseline, during and after 8 weeks of training. Protein was measured pre- and post-training. At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. Our results indicate that exercise-induced stimulation of MMPs is preserved in skeletal muscle of patients with T2DM. This early stage of diabetes may provide an opportunity for intervention and prevention of complications.

AB - Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) play a critical role during vascular remodelling, in both health and disease. Impaired MMP regulation is associated with many diabetes-related complications. This study examined whether exercise-induced regulation of MMPs is maintained in the skeletal muscle of patients with uncomplicated type 2 diabetes (T2DM). Subjects [12 T2DM, 9 healthy control subjects (CON)] underwent 8 weeks of physical training. Messenger RNA (mRNA) was measured at baseline, during and after 8 weeks of training. Protein was measured pre- and post-training. At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. Our results indicate that exercise-induced stimulation of MMPs is preserved in skeletal muscle of patients with T2DM. This early stage of diabetes may provide an opportunity for intervention and prevention of complications.

U2 - 10.1177/1479164114535943

DO - 10.1177/1479164114535943

M3 - Journal article

C2 - 24903024

VL - 11

SP - 324

EP - 334

JO - Diabetes and Vascular Disease Research

JF - Diabetes and Vascular Disease Research

SN - 1479-1641

IS - 5

ER -

ID: 119464177