Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats. / Poulsen, Steen Seier; Nexø, Ebba.

In: Gut, Vol. 27, No. 12, 12.1986, p. 1443-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS & Nexø, E 1986, 'Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats', Gut, vol. 27, no. 12, pp. 1443-9.

APA

Poulsen, S. S., & Nexø, E. (1986). Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats. Gut, 27(12), 1443-9.

Vancouver

Poulsen SS, Nexø E. Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats. Gut. 1986 Dec;27(12):1443-9.

Author

Poulsen, Steen Seier ; Nexø, Ebba. / Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats. In: Gut. 1986 ; Vol. 27, No. 12. pp. 1443-9.

Bibtex

@article{2bfdb45b32ab419d9af378bb8b69050d,
title = "Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats",
abstract = "The effect of extirpation of the submandibular glands, an exocrine organ for epidermal growth factor/urogastrone (EGF/URO), and the effect of oral administration of synthetic human (EGF/URO) on healing of chronic gastric ulcers in rats has been investigated. Removal of the submandibular glands delayed healing of chronic gastric ulcers when examined after 50, 100, and 200 days. Oral administration of synthetic human EGF/URO stimulated gastric ulcer healing when examined after 25 and 50 days of treatment. The effect of synthetic human EGF/URO was comparable with that of cimetidine. The combined administration of synthetic human EGF/URO and cimetidine further increased healing of gastric ulcers compared with administration of each substance. Neither synthetic human EGF/URO, nor removal of the submandibular glands had any influence on gastric acid secretion. This study showed that the submandibular glands influence healing of chronic gastric ulcers and suggest that EGF/URO participate in healing of chronic gastric ulcers in rats.",
keywords = "Animals, Chronic Disease, Cimetidine, Combined Modality Therapy, Epidermal Growth Factor, Female, Gastric Acid, Rats, Rats, Inbred Strains, Stomach Ulcer, Submandibular Gland",
author = "Poulsen, {Steen Seier} and Ebba Nex{\o}",
year = "1986",
month = dec,
language = "English",
volume = "27",
pages = "1443--9",
journal = "Gut",
issn = "0017-5749",
publisher = "B M J Group",
number = "12",

}

RIS

TY - JOUR

T1 - Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1986/12

Y1 - 1986/12

N2 - The effect of extirpation of the submandibular glands, an exocrine organ for epidermal growth factor/urogastrone (EGF/URO), and the effect of oral administration of synthetic human (EGF/URO) on healing of chronic gastric ulcers in rats has been investigated. Removal of the submandibular glands delayed healing of chronic gastric ulcers when examined after 50, 100, and 200 days. Oral administration of synthetic human EGF/URO stimulated gastric ulcer healing when examined after 25 and 50 days of treatment. The effect of synthetic human EGF/URO was comparable with that of cimetidine. The combined administration of synthetic human EGF/URO and cimetidine further increased healing of gastric ulcers compared with administration of each substance. Neither synthetic human EGF/URO, nor removal of the submandibular glands had any influence on gastric acid secretion. This study showed that the submandibular glands influence healing of chronic gastric ulcers and suggest that EGF/URO participate in healing of chronic gastric ulcers in rats.

AB - The effect of extirpation of the submandibular glands, an exocrine organ for epidermal growth factor/urogastrone (EGF/URO), and the effect of oral administration of synthetic human (EGF/URO) on healing of chronic gastric ulcers in rats has been investigated. Removal of the submandibular glands delayed healing of chronic gastric ulcers when examined after 50, 100, and 200 days. Oral administration of synthetic human EGF/URO stimulated gastric ulcer healing when examined after 25 and 50 days of treatment. The effect of synthetic human EGF/URO was comparable with that of cimetidine. The combined administration of synthetic human EGF/URO and cimetidine further increased healing of gastric ulcers compared with administration of each substance. Neither synthetic human EGF/URO, nor removal of the submandibular glands had any influence on gastric acid secretion. This study showed that the submandibular glands influence healing of chronic gastric ulcers and suggest that EGF/URO participate in healing of chronic gastric ulcers in rats.

KW - Animals

KW - Chronic Disease

KW - Cimetidine

KW - Combined Modality Therapy

KW - Epidermal Growth Factor

KW - Female

KW - Gastric Acid

KW - Rats

KW - Rats, Inbred Strains

KW - Stomach Ulcer

KW - Submandibular Gland

M3 - Journal article

C2 - 3492412

VL - 27

SP - 1443

EP - 1449

JO - Gut

JF - Gut

SN - 0017-5749

IS - 12

ER -

ID: 47488797