Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients
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Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients. / Dela, Flemming; Stallknecht, Bente Merete.
In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 299, No. 1, 01.07.2010, p. E80-91.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients
AU - Dela, Flemming
AU - Stallknecht, Bente Merete
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Physical training affects insulin secretion and action, but there is a paucity of data on the direct effects in skeletal muscle and adipose tissue and on the effect of training in first-degree relatives (FDR) of patients with type 2 diabetes. We studied insulin action at the whole body level and peripherally in skeletal muscle and adipose tissue as well as insulin-secretory capacity in seven FDR and eight control (CON) subjects before and after 12 wk of endurance training. Training improved physical fitness. Insulin-mediated glucose uptake (GU) increased (whole body and leg; P <0.05) after training in CON but not in FDR, whereas glucose-mediated GU increased (P <0.05) in both groups. Adipose tissue GU was not affected by training, but it was higher (abdominal, P <0.05; femoral, P = 0.09) in FDR compared with CON. Training increased skeletal muscle lipolysis (P <0.05), and it was markedly higher (P <0.05) in subcutaneous abdominal than in femoral adipose tissue and quadriceps muscle with no difference between FDR and CON. Glucose-stimulated insulin secretion was lower in FDR compared with CON, but no effect of training was seen. Glucagon-like peptide-1 stimulated insulin secretion five- to sevenfold. We conclude that insulin-secretory capacity is lower in FDR than in CON and that there is dissociation between training-induced changes in insulin secretion and insulin-mediated GU. Maximal GU rates are similar between groups and increases with physical training.
AB - Physical training affects insulin secretion and action, but there is a paucity of data on the direct effects in skeletal muscle and adipose tissue and on the effect of training in first-degree relatives (FDR) of patients with type 2 diabetes. We studied insulin action at the whole body level and peripherally in skeletal muscle and adipose tissue as well as insulin-secretory capacity in seven FDR and eight control (CON) subjects before and after 12 wk of endurance training. Training improved physical fitness. Insulin-mediated glucose uptake (GU) increased (whole body and leg; P <0.05) after training in CON but not in FDR, whereas glucose-mediated GU increased (P <0.05) in both groups. Adipose tissue GU was not affected by training, but it was higher (abdominal, P <0.05; femoral, P = 0.09) in FDR compared with CON. Training increased skeletal muscle lipolysis (P <0.05), and it was markedly higher (P <0.05) in subcutaneous abdominal than in femoral adipose tissue and quadriceps muscle with no difference between FDR and CON. Glucose-stimulated insulin secretion was lower in FDR compared with CON, but no effect of training was seen. Glucagon-like peptide-1 stimulated insulin secretion five- to sevenfold. We conclude that insulin-secretory capacity is lower in FDR than in CON and that there is dissociation between training-induced changes in insulin secretion and insulin-mediated GU. Maximal GU rates are similar between groups and increases with physical training.
KW - Adipose Tissue
KW - Adult
KW - Blood Glucose
KW - Body Composition
KW - C-Peptide
KW - Diabetes Mellitus, Type 2
KW - Exercise
KW - Fatty Acids, Nonesterified
KW - Genetic Predisposition to Disease
KW - Glucagon-Like Peptide 1
KW - Glucose Clamp Technique
KW - Humans
KW - Insulin
KW - Lactic Acid
KW - Male
KW - Muscle, Skeletal
KW - Oxygen Consumption
U2 - 10.1152/ajpendo.00765.2009
DO - 10.1152/ajpendo.00765.2009
M3 - Journal article
C2 - 20407006
VL - 299
SP - E80-91
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
SN - 0193-1849
IS - 1
ER -
ID: 33941148