Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics. / Larsen, Anders Peter; Olesen, Søren-Peter.

In: P L o S One, Vol. 5, No. 2, 2010, p. e9021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Larsen, AP & Olesen, S-P 2010, 'Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics', P L o S One, vol. 5, no. 2, pp. e9021. https://doi.org/10.1371/journal.pone.0009021

APA

Larsen, A. P., & Olesen, S-P. (2010). Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics. P L o S One, 5(2), e9021. https://doi.org/10.1371/journal.pone.0009021

Vancouver

Larsen AP, Olesen S-P. Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics. P L o S One. 2010;5(2):e9021. https://doi.org/10.1371/journal.pone.0009021

Author

Larsen, Anders Peter ; Olesen, Søren-Peter. / Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics. In: P L o S One. 2010 ; Vol. 5, No. 2. pp. e9021.

Bibtex

@article{5bbef23d58fb41d3883a12e635fa5b4e,
title = "Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics",
abstract = "The repolarizing cardiac rapid delayed rectifier current, I(Kr), is composed of ERG1 channels. It has been suggested that two isoforms of the ERG1 protein, ERG1a and ERG1b, both contribute to I(Kr). Marked heterogeneity in the kinetic properties of native I(Kr) has been described. We hypothesized that the heterogeneity of native I(Kr) can be reproduced by differential expression of ERG1a and ERG1b isoforms. Furthermore, the functional consequences of differential expression of ERG1 isoforms were explored as a potential mechanism underlying native heterogeneity of action potential duration (APD) and restitution.",
keywords = "Action Potentials, Animals, Cell Line, Computer Simulation, Ether-A-Go-Go Potassium Channels, Female, Humans, Kinetics, Markov Chains, Membrane Potentials, Models, Biological, Myocytes, Cardiac, Oocytes, Patch-Clamp Techniques, Protein Isoforms, Transfection, Xenopus laevis",
author = "Larsen, {Anders Peter} and S{\o}ren-Peter Olesen",
year = "2010",
doi = "10.1371/journal.pone.0009021",
language = "English",
volume = "5",
pages = "e9021",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics

AU - Larsen, Anders Peter

AU - Olesen, Søren-Peter

PY - 2010

Y1 - 2010

N2 - The repolarizing cardiac rapid delayed rectifier current, I(Kr), is composed of ERG1 channels. It has been suggested that two isoforms of the ERG1 protein, ERG1a and ERG1b, both contribute to I(Kr). Marked heterogeneity in the kinetic properties of native I(Kr) has been described. We hypothesized that the heterogeneity of native I(Kr) can be reproduced by differential expression of ERG1a and ERG1b isoforms. Furthermore, the functional consequences of differential expression of ERG1 isoforms were explored as a potential mechanism underlying native heterogeneity of action potential duration (APD) and restitution.

AB - The repolarizing cardiac rapid delayed rectifier current, I(Kr), is composed of ERG1 channels. It has been suggested that two isoforms of the ERG1 protein, ERG1a and ERG1b, both contribute to I(Kr). Marked heterogeneity in the kinetic properties of native I(Kr) has been described. We hypothesized that the heterogeneity of native I(Kr) can be reproduced by differential expression of ERG1a and ERG1b isoforms. Furthermore, the functional consequences of differential expression of ERG1 isoforms were explored as a potential mechanism underlying native heterogeneity of action potential duration (APD) and restitution.

KW - Action Potentials

KW - Animals

KW - Cell Line

KW - Computer Simulation

KW - Ether-A-Go-Go Potassium Channels

KW - Female

KW - Humans

KW - Kinetics

KW - Markov Chains

KW - Membrane Potentials

KW - Models, Biological

KW - Myocytes, Cardiac

KW - Oocytes

KW - Patch-Clamp Techniques

KW - Protein Isoforms

KW - Transfection

KW - Xenopus laevis

U2 - 10.1371/journal.pone.0009021

DO - 10.1371/journal.pone.0009021

M3 - Journal article

C2 - 20126398

VL - 5

SP - e9021

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

ER -

ID: 40348531