Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

Research output: Contribution to journalJournal article

Standard

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. / Krzystanek, Katarzyna; Rasmussen, Hanne Borger; Grunnet, Morten; Staub, Olivier; Olesen, Søren-Peter; Abriel, Hugues; Jespersen, Thomas.

In: Heart Rhythm, Vol. 9, No. 3, 2012, p. 440-8.

Research output: Contribution to journalJournal article

Harvard

Krzystanek, K, Rasmussen, HB, Grunnet, M, Staub, O, Olesen, S-P, Abriel, H & Jespersen, T 2012, 'Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels', Heart Rhythm, vol. 9, no. 3, pp. 440-8. https://doi.org/10.1016/j.hrthm.2011.10.026

APA

Krzystanek, K., Rasmussen, H. B., Grunnet, M., Staub, O., Olesen, S-P., Abriel, H., & Jespersen, T. (2012). Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. Heart Rhythm, 9(3), 440-8. https://doi.org/10.1016/j.hrthm.2011.10.026

Vancouver

Krzystanek K, Rasmussen HB, Grunnet M, Staub O, Olesen S-P, Abriel H et al. Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. Heart Rhythm. 2012;9(3):440-8. https://doi.org/10.1016/j.hrthm.2011.10.026

Author

Krzystanek, Katarzyna ; Rasmussen, Hanne Borger ; Grunnet, Morten ; Staub, Olivier ; Olesen, Søren-Peter ; Abriel, Hugues ; Jespersen, Thomas. / Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. In: Heart Rhythm. 2012 ; Vol. 9, No. 3. pp. 440-8.

Bibtex

@article{576184a457494ece9f434d8b3fc86bb0,
title = "Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels",
abstract = "KCNQ1 (Kv7.1), together with its KCNE {\ss} subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes. Nedd4/Nedd4-like (neuronal precursor cell-expressed developmentally downregulated 4) ubiquitin-protein ligases interact with the KCNQ1 potassium channel through a PY motif located in the C terminus of KCNQ1. This interaction induces ubiquitylation of KCNQ1, resulting in a reduced surface density of the channel. It was reported recently that the epithelial sodium channel is regulated by the reverse process-deubiquitylation-mediated by USP2 (ubiquitin-specific protease 2).",
author = "Katarzyna Krzystanek and Rasmussen, {Hanne Borger} and Morten Grunnet and Olivier Staub and S{\o}ren-Peter Olesen and Hugues Abriel and Thomas Jespersen",
note = "Copyright {\^A}{\circledC} 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.",
year = "2012",
doi = "10.1016/j.hrthm.2011.10.026",
language = "English",
volume = "9",
pages = "440--8",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

AU - Krzystanek, Katarzyna

AU - Rasmussen, Hanne Borger

AU - Grunnet, Morten

AU - Staub, Olivier

AU - Olesen, Søren-Peter

AU - Abriel, Hugues

AU - Jespersen, Thomas

N1 - Copyright © 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

PY - 2012

Y1 - 2012

N2 - KCNQ1 (Kv7.1), together with its KCNE ß subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes. Nedd4/Nedd4-like (neuronal precursor cell-expressed developmentally downregulated 4) ubiquitin-protein ligases interact with the KCNQ1 potassium channel through a PY motif located in the C terminus of KCNQ1. This interaction induces ubiquitylation of KCNQ1, resulting in a reduced surface density of the channel. It was reported recently that the epithelial sodium channel is regulated by the reverse process-deubiquitylation-mediated by USP2 (ubiquitin-specific protease 2).

AB - KCNQ1 (Kv7.1), together with its KCNE ß subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes. Nedd4/Nedd4-like (neuronal precursor cell-expressed developmentally downregulated 4) ubiquitin-protein ligases interact with the KCNQ1 potassium channel through a PY motif located in the C terminus of KCNQ1. This interaction induces ubiquitylation of KCNQ1, resulting in a reduced surface density of the channel. It was reported recently that the epithelial sodium channel is regulated by the reverse process-deubiquitylation-mediated by USP2 (ubiquitin-specific protease 2).

U2 - 10.1016/j.hrthm.2011.10.026

DO - 10.1016/j.hrthm.2011.10.026

M3 - Journal article

C2 - 22024150

VL - 9

SP - 440

EP - 448

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 3

ER -

ID: 38381728