Cysteamine-induced duodenal ulcer and acid secretion in the rat

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Cysteamine-induced duodenal ulcer and acid secretion in the rat. / Poulsen, Steen Seier.

In: Scandinavian Journal of Gastroenterology, Vol. 15, No. 5, 1980, p. 621-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS 1980, 'Cysteamine-induced duodenal ulcer and acid secretion in the rat', Scandinavian Journal of Gastroenterology, vol. 15, no. 5, pp. 621-4.

APA

Poulsen, S. S. (1980). Cysteamine-induced duodenal ulcer and acid secretion in the rat. Scandinavian Journal of Gastroenterology, 15(5), 621-4.

Vancouver

Poulsen SS. Cysteamine-induced duodenal ulcer and acid secretion in the rat. Scandinavian Journal of Gastroenterology. 1980;15(5):621-4.

Author

Poulsen, Steen Seier. / Cysteamine-induced duodenal ulcer and acid secretion in the rat. In: Scandinavian Journal of Gastroenterology. 1980 ; Vol. 15, No. 5. pp. 621-4.

Bibtex

@article{8e6de0c62b764a8eab5123da8e7ba967,
title = "Cysteamine-induced duodenal ulcer and acid secretion in the rat",
abstract = "Duodenal ulcers can be produced in rats within 24 h by a single subcutaneous administration of cysteamine. To determine the role of gastric acid secretion in the pathogenesis of these ulcers, secretory and pathoanatomic studies were performed in chronic fistula rats ater an ulcerogenic dose of cysteamine. A prolonged increase of acid secretion was seen after cysteamine, reaching fourfold the basal level after 5 h. The acid response lasted for 10 to 11 h. After vagotomy cysteamine-induced acid secretion was markedly reduced. Ulcer formation was prevented by vagotomy and by drainage of the gastric juice before it entered the duodenum. When a gastric acid output equivalent to that produced by the ulcerogenic dose of cysteamine was induced by repeated injections of pentagastrin, no mucosal changes were seen in the duodenum. These results indicate that, although some acid in the duodenum is required for ulcer formation, the hypersecretion of acid induced by cysteamine is not the only factor responsible for the development of duodenal ulcer.",
keywords = "Animals, Cysteamine, Duodenal Ulcer, Female, Gastric Acid, Gastric Fistula, Intestinal Mucosa, Pentagastrin, Rats, Secretory Rate, Vagotomy",
author = "Poulsen, {Steen Seier}",
year = "1980",
language = "English",
volume = "15",
pages = "621--4",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Cysteamine-induced duodenal ulcer and acid secretion in the rat

AU - Poulsen, Steen Seier

PY - 1980

Y1 - 1980

N2 - Duodenal ulcers can be produced in rats within 24 h by a single subcutaneous administration of cysteamine. To determine the role of gastric acid secretion in the pathogenesis of these ulcers, secretory and pathoanatomic studies were performed in chronic fistula rats ater an ulcerogenic dose of cysteamine. A prolonged increase of acid secretion was seen after cysteamine, reaching fourfold the basal level after 5 h. The acid response lasted for 10 to 11 h. After vagotomy cysteamine-induced acid secretion was markedly reduced. Ulcer formation was prevented by vagotomy and by drainage of the gastric juice before it entered the duodenum. When a gastric acid output equivalent to that produced by the ulcerogenic dose of cysteamine was induced by repeated injections of pentagastrin, no mucosal changes were seen in the duodenum. These results indicate that, although some acid in the duodenum is required for ulcer formation, the hypersecretion of acid induced by cysteamine is not the only factor responsible for the development of duodenal ulcer.

AB - Duodenal ulcers can be produced in rats within 24 h by a single subcutaneous administration of cysteamine. To determine the role of gastric acid secretion in the pathogenesis of these ulcers, secretory and pathoanatomic studies were performed in chronic fistula rats ater an ulcerogenic dose of cysteamine. A prolonged increase of acid secretion was seen after cysteamine, reaching fourfold the basal level after 5 h. The acid response lasted for 10 to 11 h. After vagotomy cysteamine-induced acid secretion was markedly reduced. Ulcer formation was prevented by vagotomy and by drainage of the gastric juice before it entered the duodenum. When a gastric acid output equivalent to that produced by the ulcerogenic dose of cysteamine was induced by repeated injections of pentagastrin, no mucosal changes were seen in the duodenum. These results indicate that, although some acid in the duodenum is required for ulcer formation, the hypersecretion of acid induced by cysteamine is not the only factor responsible for the development of duodenal ulcer.

KW - Animals

KW - Cysteamine

KW - Duodenal Ulcer

KW - Female

KW - Gastric Acid

KW - Gastric Fistula

KW - Intestinal Mucosa

KW - Pentagastrin

KW - Rats

KW - Secretory Rate

KW - Vagotomy

M3 - Journal article

C2 - 7444368

VL - 15

SP - 621

EP - 624

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 5

ER -

ID: 47490136