Cycling matters: Sex hormone regulation of vascular potassium channels

Research output: Contribution to journal › Review › Research › peer-review

Standard

Cycling matters : Sex hormone regulation of vascular potassium channels. / Baldwin, Samuel N.; Jepps, Thomas A.; Greenwood, Iain A.

In: Channels, Vol. 17, No. 1, 2217637, 2023.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Baldwin, SN, Jepps, TA & Greenwood, IA 2023, 'Cycling matters: Sex hormone regulation of vascular potassium channels', Channels, vol. 17, no. 1, 2217637. https://doi.org/10.1080/19336950.2023.2217637

APA

Baldwin, S. N., Jepps, T. A., & Greenwood, I. A. (2023). Cycling matters: Sex hormone regulation of vascular potassium channels. Channels, 17(1), [2217637]. https://doi.org/10.1080/19336950.2023.2217637

Vancouver

Baldwin SN, Jepps TA, Greenwood IA. Cycling matters: Sex hormone regulation of vascular potassium channels. Channels. 2023;17(1). 2217637. https://doi.org/10.1080/19336950.2023.2217637

Author

Baldwin, Samuel N. ; Jepps, Thomas A. ; Greenwood, Iain A. / Cycling matters : Sex hormone regulation of vascular potassium channels. In: Channels. 2023 ; Vol. 17, No. 1.

Bibtex

@article{ac35ed5319044c2e993f751185445224,
title = "Cycling matters: Sex hormone regulation of vascular potassium channels",
abstract = "Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic preclinical scientific research. Recent research by our own laboratory indicates that cyclical changes in serum concentrations of sex -hormones across the rat estrus cycle, primary estradiol, have significant consequences for the subcellular trafficking and function of KV. Vascular potassium channels, including KV, are essential components of vascular reactivity. Our study represents a small part of a growing field of literature aimed at determining the role of sex hormones in regulating arterial ion channel function. This review covers key findings describing the current understanding of sex hormone regulation of vascular potassium channels, with a focus on KV channels. Further, we highlight areas of research where the estrus cycle should be considered in future studies to determine the consequences of physiological oscillations in concentrations of sex hormones on vascular potassium channel function.",
keywords = "estrogens, estrus cycle, ion channels, progesterone, testosterone, vascular biology",
author = "Baldwin, {Samuel N.} and Jepps, {Thomas A.} and Greenwood, {Iain A.}",
year = "2023",
doi = "10.1080/19336950.2023.2217637",
language = "English",
volume = "17",
journal = "Channels",
issn = "1933-6950",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Cycling matters

T2 - Sex hormone regulation of vascular potassium channels

AU - Baldwin, Samuel N.

AU - Jepps, Thomas A.

AU - Greenwood, Iain A.

PY - 2023

Y1 - 2023

N2 - Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic preclinical scientific research. Recent research by our own laboratory indicates that cyclical changes in serum concentrations of sex -hormones across the rat estrus cycle, primary estradiol, have significant consequences for the subcellular trafficking and function of KV. Vascular potassium channels, including KV, are essential components of vascular reactivity. Our study represents a small part of a growing field of literature aimed at determining the role of sex hormones in regulating arterial ion channel function. This review covers key findings describing the current understanding of sex hormone regulation of vascular potassium channels, with a focus on KV channels. Further, we highlight areas of research where the estrus cycle should be considered in future studies to determine the consequences of physiological oscillations in concentrations of sex hormones on vascular potassium channel function.

AB - Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic preclinical scientific research. Recent research by our own laboratory indicates that cyclical changes in serum concentrations of sex -hormones across the rat estrus cycle, primary estradiol, have significant consequences for the subcellular trafficking and function of KV. Vascular potassium channels, including KV, are essential components of vascular reactivity. Our study represents a small part of a growing field of literature aimed at determining the role of sex hormones in regulating arterial ion channel function. This review covers key findings describing the current understanding of sex hormone regulation of vascular potassium channels, with a focus on KV channels. Further, we highlight areas of research where the estrus cycle should be considered in future studies to determine the consequences of physiological oscillations in concentrations of sex hormones on vascular potassium channel function.

KW - estrogens

KW - estrus cycle

KW - ion channels

KW - progesterone

KW - testosterone

KW - vascular biology

UR - http://www.scopus.com/inward/record.url?scp=85160381212&partnerID=8YFLogxK

U2 - 10.1080/19336950.2023.2217637

DO - 10.1080/19336950.2023.2217637

M3 - Review

C2 - 37243715

AN - SCOPUS:85160381212

VL - 17

JO - Channels

JF - Channels

SN - 1933-6950

IS - 1

M1 - 2217637

ER -

ID: 353704211