Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation

Research output: Contribution to journal › Journal article › Research › peer-review

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Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation. / Linz, Dominik; Verheule, Sander; Isaacs, Aaron; Schotten, Ulrich.

In: Arrhythmia and Electrophysiology Review, Vol. 10, No. 3, 2021, p. 132-139.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Linz, D, Verheule, S, Isaacs, A & Schotten, U 2021, 'Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation', Arrhythmia and Electrophysiology Review, vol. 10, no. 3, pp. 132-139. https://doi.org/10.15420/aer.2020.51

APA

Linz, D., Verheule, S., Isaacs, A., & Schotten, U. (2021). Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation. Arrhythmia and Electrophysiology Review, 10(3), 132-139. https://doi.org/10.15420/aer.2020.51

Vancouver

Linz D, Verheule S, Isaacs A, Schotten U. Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation. Arrhythmia and Electrophysiology Review. 2021;10(3):132-139. https://doi.org/10.15420/aer.2020.51

Author

Linz, Dominik ; Verheule, Sander ; Isaacs, Aaron ; Schotten, Ulrich. / Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation. In: Arrhythmia and Electrophysiology Review. 2021 ; Vol. 10, No. 3. pp. 132-139.

Bibtex

@article{1ebc21f633e843c5a216087dfe616a47,
title = "Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation",
abstract = "Successful translation of research focussing on atrial arrhythmogenic mechanisms has potential to provide a mechanism-tailored classification and to support personalised treatment approaches in patients with AF. The clinical uptake and clinical implementation of new diagnostic techniques and treatment strategies require translational research approaches on various levels. Diagnostic translation involves the development of clinical diagnostic tools. Additionally, multidisciplinary teams are required for collaborative translation to describe genetic mechanisms, molecular pathways, electrophysiological characteristics and concomitant risk factors. In this article, current approaches for AF substrate characterisation, analysis of genes potentially involved in AF and strategies for AF risk factor assessment are summarised. The authors discuss challenges and obstacles to clinical translation and implementation into clinical practice.",
keywords = "Atrial fibrillation, Genes, Mechanisms, Risk factors, Substrate",
author = "Dominik Linz and Sander Verheule and Aaron Isaacs and Ulrich Schotten",
year = "2021",
doi = "10.15420/aer.2020.51",
language = "English",
volume = "10",
pages = "132--139",
journal = "Arrhythmia and Electrophysiology Review",
issn = "2050-3369",
publisher = "Radcliffe Publishing",
number = "3",

}

RIS

TY - JOUR

T1 - Considerations for the assessment of substrates, genetics and risk factors in patients with atrial fibrillation

AU - Linz, Dominik

AU - Verheule, Sander

AU - Isaacs, Aaron

AU - Schotten, Ulrich

PY - 2021

Y1 - 2021

N2 - Successful translation of research focussing on atrial arrhythmogenic mechanisms has potential to provide a mechanism-tailored classification and to support personalised treatment approaches in patients with AF. The clinical uptake and clinical implementation of new diagnostic techniques and treatment strategies require translational research approaches on various levels. Diagnostic translation involves the development of clinical diagnostic tools. Additionally, multidisciplinary teams are required for collaborative translation to describe genetic mechanisms, molecular pathways, electrophysiological characteristics and concomitant risk factors. In this article, current approaches for AF substrate characterisation, analysis of genes potentially involved in AF and strategies for AF risk factor assessment are summarised. The authors discuss challenges and obstacles to clinical translation and implementation into clinical practice.

AB - Successful translation of research focussing on atrial arrhythmogenic mechanisms has potential to provide a mechanism-tailored classification and to support personalised treatment approaches in patients with AF. The clinical uptake and clinical implementation of new diagnostic techniques and treatment strategies require translational research approaches on various levels. Diagnostic translation involves the development of clinical diagnostic tools. Additionally, multidisciplinary teams are required for collaborative translation to describe genetic mechanisms, molecular pathways, electrophysiological characteristics and concomitant risk factors. In this article, current approaches for AF substrate characterisation, analysis of genes potentially involved in AF and strategies for AF risk factor assessment are summarised. The authors discuss challenges and obstacles to clinical translation and implementation into clinical practice.

KW - Atrial fibrillation

KW - Genes

KW - Mechanisms

KW - Risk factors

KW - Substrate

UR - http://www.scopus.com/inward/record.url?scp=85118771370&partnerID=8YFLogxK

U2 - 10.15420/aer.2020.51

DO - 10.15420/aer.2020.51

M3 - Journal article

C2 - 34777816

AN - SCOPUS:85118771370

VL - 10

SP - 132

EP - 139

JO - Arrhythmia and Electrophysiology Review

JF - Arrhythmia and Electrophysiology Review

SN - 2050-3369

IS - 3

ER -

ID: 284903418