Cobalamin and its binding protein in rat milk
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Cobalamin and its binding protein in rat milk. / Raaberg, Lasse; Nexø, Ebba; Poulsen, Steen Seier.
In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 49, No. 6, 10.1989, p. 529-35.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cobalamin and its binding protein in rat milk
AU - Raaberg, Lasse
AU - Nexø, Ebba
AU - Poulsen, Steen Seier
PY - 1989/10
Y1 - 1989/10
N2 - Cobalamin and its binding protein, haptocorrin, are present in rat milk throughout the lactation period. The concentration of cobalamin is approximately 0.3-times the concentration of the unsaturated binding protein. The concentration of the unsaturated cobalamin-binding protein varies between 18 nmol l-1 and 16 nmol l-1. The binding protein has a Stokes radius of 2.49 nm when saturated with cobalamin and 2.61 nm when unsaturated. It binds cobalamin over a broad range of pH and is able to bind cobinamide also. With immunohistochemistry, we find haptocorrin immunoreactivity in the mammary glands and in the sebaceous glands of the nipple.
AB - Cobalamin and its binding protein, haptocorrin, are present in rat milk throughout the lactation period. The concentration of cobalamin is approximately 0.3-times the concentration of the unsaturated binding protein. The concentration of the unsaturated cobalamin-binding protein varies between 18 nmol l-1 and 16 nmol l-1. The binding protein has a Stokes radius of 2.49 nm when saturated with cobalamin and 2.61 nm when unsaturated. It binds cobalamin over a broad range of pH and is able to bind cobinamide also. With immunohistochemistry, we find haptocorrin immunoreactivity in the mammary glands and in the sebaceous glands of the nipple.
KW - Animals
KW - Chromatography, Gel
KW - Female
KW - Immunohistochemistry
KW - Lactation
KW - Mammary Glands, Animal
KW - Milk
KW - Pregnancy
KW - Rats
KW - Rats, Inbred Strains
KW - Transcobalamins
KW - Vitamin B 12
M3 - Journal article
C2 - 2595247
VL - 49
SP - 529
EP - 535
JO - Scandinavian Journal of Clinical & Laboratory Investigation
JF - Scandinavian Journal of Clinical & Laboratory Investigation
SN - 0036-5513
IS - 6
ER -
ID: 47488240