Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat. / Vinter-Jensen, Lars; Smerup, Morten Holdgaard; Jørgensen, P E; Juhl, C O; Orntoft, T; Poulsen, Steen Seier; Nexø, Ebba.

In: Urological Research, Vol. 24, No. 1, 1996, p. 15-21.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vinter-Jensen, L, Smerup, MH, Jørgensen, PE, Juhl, CO, Orntoft, T, Poulsen, SS & Nexø, E 1996, 'Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat', Urological Research, vol. 24, no. 1, pp. 15-21.

APA

Vinter-Jensen, L., Smerup, M. H., Jørgensen, P. E., Juhl, C. O., Orntoft, T., Poulsen, S. S., & Nexø, E. (1996). Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat. Urological Research, 24(1), 15-21.

Vancouver

Vinter-Jensen L, Smerup MH, Jørgensen PE, Juhl CO, Orntoft T, Poulsen SS et al. Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat. Urological Research. 1996;24(1):15-21.

Author

Vinter-Jensen, Lars ; Smerup, Morten Holdgaard ; Jørgensen, P E ; Juhl, C O ; Orntoft, T ; Poulsen, Steen Seier ; Nexø, Ebba. / Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat. In: Urological Research. 1996 ; Vol. 24, No. 1. pp. 15-21.

Bibtex

@article{a75db4928429457d8a5d95bd09aef31d,
title = "Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat",
abstract = "Twenty-four male Wistar rats, 8 weeks old, were allocated into three groups and treated with human recombinant epidermal growth factor (EGF) administered subcutaneously in doses of 0, 30, and 150 micrograms/kg per day for 4 weeks. Blood sampling was done every 2nd week and urine sampling was done for 2 consecutive days every week. The most striking finding was that the ureters were dose dependently enlarged, due to growth of all layers of the ureteric wall. The urothelium of the bladder showed considerable hyperplasticity with a widening of the basal proliferative compartment and a normal differentiation pattern as observed by the expression of carbohydrate epitopes, characterized with lectinohistochemistry. Blood examination revealed a decrease in blood haemoglobin concentration and a slight increase in serum creatinine concentration in the high-dose group. There were no effects of EGF on the urinary excretion of electrolytes, proteins, and endogenous EGF.",
keywords = "Animals, Creatinine, Dose-Response Relationship, Drug, Epidermal Growth Factor, Hemoglobins, Humans, Lectins, Male, Osmolar Concentration, Rats, Rats, Wistar, Recombinant Proteins, Time Factors, Urinary Tract",
author = "Lars Vinter-Jensen and Smerup, {Morten Holdgaard} and J{\o}rgensen, {P E} and Juhl, {C O} and T Orntoft and Poulsen, {Steen Seier} and Ebba Nex{\o}",
year = "1996",
language = "English",
volume = "24",
pages = "15--21",
journal = "Urolithiasis",
issn = "2194-7228",
publisher = "Springer Verlag",
number = "1",

}

RIS

TY - JOUR

T1 - Chronic treatment with epidermal growth factor stimulates growth of the urinary tract in the rat

AU - Vinter-Jensen, Lars

AU - Smerup, Morten Holdgaard

AU - Jørgensen, P E

AU - Juhl, C O

AU - Orntoft, T

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1996

Y1 - 1996

N2 - Twenty-four male Wistar rats, 8 weeks old, were allocated into three groups and treated with human recombinant epidermal growth factor (EGF) administered subcutaneously in doses of 0, 30, and 150 micrograms/kg per day for 4 weeks. Blood sampling was done every 2nd week and urine sampling was done for 2 consecutive days every week. The most striking finding was that the ureters were dose dependently enlarged, due to growth of all layers of the ureteric wall. The urothelium of the bladder showed considerable hyperplasticity with a widening of the basal proliferative compartment and a normal differentiation pattern as observed by the expression of carbohydrate epitopes, characterized with lectinohistochemistry. Blood examination revealed a decrease in blood haemoglobin concentration and a slight increase in serum creatinine concentration in the high-dose group. There were no effects of EGF on the urinary excretion of electrolytes, proteins, and endogenous EGF.

AB - Twenty-four male Wistar rats, 8 weeks old, were allocated into three groups and treated with human recombinant epidermal growth factor (EGF) administered subcutaneously in doses of 0, 30, and 150 micrograms/kg per day for 4 weeks. Blood sampling was done every 2nd week and urine sampling was done for 2 consecutive days every week. The most striking finding was that the ureters were dose dependently enlarged, due to growth of all layers of the ureteric wall. The urothelium of the bladder showed considerable hyperplasticity with a widening of the basal proliferative compartment and a normal differentiation pattern as observed by the expression of carbohydrate epitopes, characterized with lectinohistochemistry. Blood examination revealed a decrease in blood haemoglobin concentration and a slight increase in serum creatinine concentration in the high-dose group. There were no effects of EGF on the urinary excretion of electrolytes, proteins, and endogenous EGF.

KW - Animals

KW - Creatinine

KW - Dose-Response Relationship, Drug

KW - Epidermal Growth Factor

KW - Hemoglobins

KW - Humans

KW - Lectins

KW - Male

KW - Osmolar Concentration

KW - Rats

KW - Rats, Wistar

KW - Recombinant Proteins

KW - Time Factors

KW - Urinary Tract

M3 - Journal article

C2 - 8966836

VL - 24

SP - 15

EP - 21

JO - Urolithiasis

JF - Urolithiasis

SN - 2194-7228

IS - 1

ER -

ID: 47486931