Changes in cardiac time intervals over a decade and the risk of incident heart failure: The Copenhagen City Heart Study
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Changes in cardiac time intervals over a decade and the risk of incident heart failure : The Copenhagen City Heart Study. / Alhakak, Alia Saed; Olsen, Flemming Javier; Skaarup, Kristoffer Grundtvig; Lassen, Mats Christian Højbjerg; Johansen, Niklas Dyrby; Espersen, Caroline; Abildgaard, Ulrik; Jensen, Gorm Boje; Schnohr, Peter; Marott, Jacob Louis; Søgaard, Peter; Møgelvang, Rasmus; Biering-Sørensen, Tor.
In: International Journal of Cardiology, Vol. 386, 2023, p. 141-148.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Changes in cardiac time intervals over a decade and the risk of incident heart failure
T2 - The Copenhagen City Heart Study
AU - Alhakak, Alia Saed
AU - Olsen, Flemming Javier
AU - Skaarup, Kristoffer Grundtvig
AU - Lassen, Mats Christian Højbjerg
AU - Johansen, Niklas Dyrby
AU - Espersen, Caroline
AU - Abildgaard, Ulrik
AU - Jensen, Gorm Boje
AU - Schnohr, Peter
AU - Marott, Jacob Louis
AU - Søgaard, Peter
AU - Møgelvang, Rasmus
AU - Biering-Sørensen, Tor
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - Background: The cardiac time intervals include the isovolumic contraction time (IVCT), the left ventricular ejection time (LVET), the isovolumic relaxation time (IVRT) and the combination of all the cardiac time intervals in the myocardial performance index (MPI) (defined as [(IVCT+IVRT)/LVET)]. Whether the cardiac time intervals change over time and which clinical factors that accelerate these changes is not well-established. Additionally, whether these changes are associated with subsequent heart failure (HF), remains unknown. Methods: We investigated participants from the general population (n = 1064) who had an echocardiographic examination including color tissue Doppler imaging performed in both the 4th and 5th Copenhagen City Heart Study. The examinations were performed 10.5 years apart. Results: The IVCT, LVET, IVRT and MPI increased significantly over time. None of the investigated clinical factors were associated with increase in IVCT. Systolic blood pressure (standardized β= − 0.09) and male sex (standardized β= − 0.08) were associated with an accelerated decrease in LVET. Age (standardized β=0.26), male sex (standardized β=0.06), diastolic blood pressure (standardized β=0.08), and smoking (standardized β=0.08) were associated with an increase in IVRT, while HbA1c (standardized β= − 0.06) was associated with a decrease in IVRT. Increasing IVRT over a decade was associated with an increased risk of subsequent HF in participants aged <65 years (per 10 ms increase: HR 1.33; 95%CI (1.02–1.72), p = 0.034). Conclusion: The cardiac time increased significantly over time. Several clinical factors accelerated these changes. An increase in IVRT was associated with an increased risk of subsequent HF in participants aged <65 years.
AB - Background: The cardiac time intervals include the isovolumic contraction time (IVCT), the left ventricular ejection time (LVET), the isovolumic relaxation time (IVRT) and the combination of all the cardiac time intervals in the myocardial performance index (MPI) (defined as [(IVCT+IVRT)/LVET)]. Whether the cardiac time intervals change over time and which clinical factors that accelerate these changes is not well-established. Additionally, whether these changes are associated with subsequent heart failure (HF), remains unknown. Methods: We investigated participants from the general population (n = 1064) who had an echocardiographic examination including color tissue Doppler imaging performed in both the 4th and 5th Copenhagen City Heart Study. The examinations were performed 10.5 years apart. Results: The IVCT, LVET, IVRT and MPI increased significantly over time. None of the investigated clinical factors were associated with increase in IVCT. Systolic blood pressure (standardized β= − 0.09) and male sex (standardized β= − 0.08) were associated with an accelerated decrease in LVET. Age (standardized β=0.26), male sex (standardized β=0.06), diastolic blood pressure (standardized β=0.08), and smoking (standardized β=0.08) were associated with an increase in IVRT, while HbA1c (standardized β= − 0.06) was associated with a decrease in IVRT. Increasing IVRT over a decade was associated with an increased risk of subsequent HF in participants aged <65 years (per 10 ms increase: HR 1.33; 95%CI (1.02–1.72), p = 0.034). Conclusion: The cardiac time increased significantly over time. Several clinical factors accelerated these changes. An increase in IVRT was associated with an increased risk of subsequent HF in participants aged <65 years.
KW - Cardiac time intervals
KW - Heart failure
KW - TDI-echocardiography
U2 - 10.1016/j.ijcard.2023.05.018
DO - 10.1016/j.ijcard.2023.05.018
M3 - Journal article
C2 - 37178800
AN - SCOPUS:85160082785
VL - 386
SP - 141
EP - 148
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -
ID: 350996458