TY - JOUR

T1 - Basal and exercise-induced neuroendocrine activation in patients with heart failure and in normal subjects.

AU - Kjaer, Andreas

AU - Appel, Jon

AU - Hildebrandt, Per

AU - Petersen, Claus Leth

N1 - Keywords: Aged; Aged, 80 and over; Arginine Vasopressin; Case-Control Studies; Endothelin-1; Exercise; Exercise Tolerance; Female; Heart Failure; Humans; Male; Natriuretic Peptides; Neurosecretory Systems; Norepinephrine; Renin

PY - 2004

Y1 - 2004

N2 - BACKGROUND: Neuroendocrine activation is a pathophysiological response and an important prognostic marker in patients with chronic heart failure (CHF). Although chronic activation is well described, data on the responsiveness of the hormone systems are more limited. Most previous studies have looked at activation during maximal exercise, whereas we believe that activation at a submaximal level might be more pathophysiologically relevant. AIM: To compare exercise-induced neurohormonal activation between CHF patients and normal subjects using the same relative and submaximal workload. Subjects: Twenty-three newly-diagnosed CHF patients and 18 age- and gender-matched healthy subjects were exercised at two workloads, which were calculated to correspond to 50 and 75% of each individual's heart rate response. RESULTS: In CHF patients, baseline levels of ANP, BNP, AVP, PRA and ET-1 were elevated compared to healthy subjects. Exercise induced an increase in ANP, A and NA in both CHF patients and in normal subjects, however BNP was only increased in CHF patients and not in normal subjects. CONCLUSION: When CHF patients exercise at the same relative and submaximal level as age-matched healthy subjects, the relative increases in ANP, A and NA were similar, however, BNP levels only increased in the CHF group.

AB - BACKGROUND: Neuroendocrine activation is a pathophysiological response and an important prognostic marker in patients with chronic heart failure (CHF). Although chronic activation is well described, data on the responsiveness of the hormone systems are more limited. Most previous studies have looked at activation during maximal exercise, whereas we believe that activation at a submaximal level might be more pathophysiologically relevant. AIM: To compare exercise-induced neurohormonal activation between CHF patients and normal subjects using the same relative and submaximal workload. Subjects: Twenty-three newly-diagnosed CHF patients and 18 age- and gender-matched healthy subjects were exercised at two workloads, which were calculated to correspond to 50 and 75% of each individual's heart rate response. RESULTS: In CHF patients, baseline levels of ANP, BNP, AVP, PRA and ET-1 were elevated compared to healthy subjects. Exercise induced an increase in ANP, A and NA in both CHF patients and in normal subjects, however BNP was only increased in CHF patients and not in normal subjects. CONCLUSION: When CHF patients exercise at the same relative and submaximal level as age-matched healthy subjects, the relative increases in ANP, A and NA were similar, however, BNP levels only increased in the CHF group.

U2 - 10.1016/S1388-9842(03)00035-7

DO - 10.1016/S1388-9842(03)00035-7

M3 - Journal article

C2 - 15012916

VL - 6

SP - 29

EP - 39

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1567-4215

IS - 1

ER -