Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.

Research output: Contribution to journal › Journal article › Research › peer-review

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Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass. / Nielsen, Anders Rinnov; Hojman, Pernille; Erikstrup, Christian; Fischer, Christian Philip; Plomgaard, Peter; Mounier, Remi; Mortensen, Ole Hartvig; Broholm, Christa; Taudorf, Sarah; Krogh-Madsen, Rikke; Lindegaard, Birgitte; Petersen, Anne Marie Winther; Gehl, Julie; Pedersen, Bente Klarlund.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 11, 2008, p. 4486-93.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, AR, Hojman, P, Erikstrup, C, Fischer, CP, Plomgaard, P, Mounier, R, Mortensen, OH, Broholm, C, Taudorf, S, Krogh-Madsen, R, Lindegaard, B, Petersen, AMW, Gehl, J & Pedersen, BK 2008, 'Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.', Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, pp. 4486-93. https://doi.org/10.1210/jc.2007-2561

APA

Nielsen, A. R., Hojman, P., Erikstrup, C., Fischer, C. P., Plomgaard, P., Mounier, R., Mortensen, O. H., Broholm, C., Taudorf, S., Krogh-Madsen, R., Lindegaard, B., Petersen, A. M. W., Gehl, J., & Pedersen, B. K. (2008). Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass. Journal of Clinical Endocrinology and Metabolism, 93(11), 4486-93. https://doi.org/10.1210/jc.2007-2561

Vancouver

Nielsen AR, Hojman P, Erikstrup C, Fischer CP, Plomgaard P, Mounier R et al. Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass. Journal of Clinical Endocrinology and Metabolism. 2008;93(11):4486-93. https://doi.org/10.1210/jc.2007-2561

Author

Nielsen, Anders Rinnov ; Hojman, Pernille ; Erikstrup, Christian ; Fischer, Christian Philip ; Plomgaard, Peter ; Mounier, Remi ; Mortensen, Ole Hartvig ; Broholm, Christa ; Taudorf, Sarah ; Krogh-Madsen, Rikke ; Lindegaard, Birgitte ; Petersen, Anne Marie Winther ; Gehl, Julie ; Pedersen, Bente Klarlund. / Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass. In: Journal of Clinical Endocrinology and Metabolism. 2008 ; Vol. 93, No. 11. pp. 4486-93.

Bibtex

@article{518fabf0acd311ddb538000ea68e967b,
title = "Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.",
abstract = "Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass.",
author = "Nielsen, {Anders Rinnov} and Pernille Hojman and Christian Erikstrup and Fischer, {Christian Philip} and Peter Plomgaard and Remi Mounier and Mortensen, {Ole Hartvig} and Christa Broholm and Sarah Taudorf and Rikke Krogh-Madsen and Birgitte Lindegaard and Petersen, {Anne Marie Winther} and Julie Gehl and Pedersen, {Bente Klarlund}",
year = "2008",
doi = "10.1210/jc.2007-2561",
language = "English",
volume = "93",
pages = "4486--93",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.

AU - Nielsen, Anders Rinnov

AU - Hojman, Pernille

AU - Erikstrup, Christian

AU - Fischer, Christian Philip

AU - Plomgaard, Peter

AU - Mounier, Remi

AU - Mortensen, Ole Hartvig

AU - Broholm, Christa

AU - Taudorf, Sarah

AU - Krogh-Madsen, Rikke

AU - Lindegaard, Birgitte

AU - Petersen, Anne Marie Winther

AU - Gehl, Julie

AU - Pedersen, Bente Klarlund

PY - 2008

Y1 - 2008

N2 - Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass.

AB - Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass.

U2 - 10.1210/jc.2007-2561

DO - 10.1210/jc.2007-2561

M3 - Journal article

C2 - 18697873

VL - 93

SP - 4486

EP - 4493

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 11

ER -

ID: 8465884