Association between age, IL-10, IFN¿, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes
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Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN¿) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFN¿ gene were genotyped and serum levels of IL-10 and IFN¿ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P
| Original language | English |
|---|---|
| Journal | Diabetic Medicine Online |
| Volume | 29 |
| Issue number | 6 |
| Pages (from-to) | 734-741 |
| Number of pages | 8 |
| ISSN | 1464-5491 |
| DOIs | |
| Publication status | Published - 2012 |
ID: 38412684