Age- and sex-based normal values of layer-specific longitudinal and circumferential strain by speckle tracking echocardiography: the Copenhagen City Heart Study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Age- and sex-based normal values of layer-specific longitudinal and circumferential strain by speckle tracking echocardiography : the Copenhagen City Heart Study. / Skaarup, Kristoffer Grundtvig; Lassen, Mats Christian Højbjerg; Johansen, Niklas Dyrby; Olsen, Flemming Javier; Lind, Jannie Nørgaard; Jørgensen, Peter Godsk; Jensen, Gorm; Schnohr, Peter; Prescott, Eva; Søgaard, Peter; Møgelvang, Rasmus; Biering-Sørensen, Tor.

In: European Heart Journal Cardiovascular Imaging, Vol. 23, No. 5, 2022, p. 629–640.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Skaarup, KG, Lassen, MCH, Johansen, ND, Olsen, FJ, Lind, JN, Jørgensen, PG, Jensen, G, Schnohr, P, Prescott, E, Søgaard, P, Møgelvang, R & Biering-Sørensen, T 2022, 'Age- and sex-based normal values of layer-specific longitudinal and circumferential strain by speckle tracking echocardiography: the Copenhagen City Heart Study', European Heart Journal Cardiovascular Imaging, vol. 23, no. 5, pp. 629–640. https://doi.org/10.1093/ehjci/jeab032

APA

Skaarup, K. G., Lassen, M. C. H., Johansen, N. D., Olsen, F. J., Lind, J. N., Jørgensen, P. G., Jensen, G., Schnohr, P., Prescott, E., Søgaard, P., Møgelvang, R., & Biering-Sørensen, T. (2022). Age- and sex-based normal values of layer-specific longitudinal and circumferential strain by speckle tracking echocardiography: the Copenhagen City Heart Study. European Heart Journal Cardiovascular Imaging, 23(5), 629–640. https://doi.org/10.1093/ehjci/jeab032

Vancouver

Skaarup KG, Lassen MCH, Johansen ND, Olsen FJ, Lind JN, Jørgensen PG et al. Age- and sex-based normal values of layer-specific longitudinal and circumferential strain by speckle tracking echocardiography: the Copenhagen City Heart Study. European Heart Journal Cardiovascular Imaging. 2022;23(5):629–640. https://doi.org/10.1093/ehjci/jeab032

Author

Skaarup, Kristoffer Grundtvig ; Lassen, Mats Christian Højbjerg ; Johansen, Niklas Dyrby ; Olsen, Flemming Javier ; Lind, Jannie Nørgaard ; Jørgensen, Peter Godsk ; Jensen, Gorm ; Schnohr, Peter ; Prescott, Eva ; Søgaard, Peter ; Møgelvang, Rasmus ; Biering-Sørensen, Tor. / Age- and sex-based normal values of layer-specific longitudinal and circumferential strain by speckle tracking echocardiography : the Copenhagen City Heart Study. In: European Heart Journal Cardiovascular Imaging. 2022 ; Vol. 23, No. 5. pp. 629–640.

Bibtex

@article{cc26316d9c7d400aa20384c2647800db,
title = "Age- and sex-based normal values of layer-specific longitudinal and circumferential strain by speckle tracking echocardiography: the Copenhagen City Heart Study",
abstract = "Aims Technical advancements in 2D-speckle tracking echocardiography (2DSTE) have allowed for quantification of layer-specific global longitudinal strain (GLS) and circumferential strain (GCS) of the left ventricle (LV). The aim of this study was to establish age- and sex-based reference ranges of peak systolic layer-specific GLS and GCS and to assess normal values of regional strain. Methods and results We performed 2DSTE analysis of 1997 members of the general population from the fifth round of the Copenhagen City Heart Study, who were free of cardiovascular disease and risk factors. The mean age was 46 +/- 16 years (range 21-97) and 62% were female. Mean values for peak systolic whole wall GLS (GLS(WW.Sys)), endomycardial (GLS(Endo.Sys)), and epimyocardial (GLS(Epi.Sys)) were 19.9 +/- 2.1% (prediction interval [PI]: 15.8-24.0%), 23.5 +/- 2.5% (PI: 18.6-28.4%), and 17.3 +/- 1.9% (PI: 13.6-21.1%), respectively. Mean peak systolic whole wall GCS (GCS(WW.Sys)), was 21.6 +/- 3.7% (PI: 14.3-28.9%), endomyocardial (GCS(Endo.Sys)) was 31.9 +/- 4.7% (PI: 22.7-41.1%), and epimyocardial (GCS(Epi.Sys)) was 14.3 +/- 3.8% (PI: 6.8-21.8%). A significant discrepancy in normal strain values between males and females was observed. Men had lower mean values and lower reference limits for all strain parameters. Furthermore, GLS and GCS changed differently with age in males and females. Finally, regional LS decreased from the apical to the basal LV region in both sexes, and regional CS varied significantly by LV segment. Conclusion In this study, we reported age- and sex-based reference ranges of layer-specific GLS and GCS. These reference ranges varied significantly with sex and age.",
keywords = "2D-speckle tracking echocardiography, layer-specific global longitudinal strain, layer-specific global circumferential strain, normal values, MYOCARDIAL DEFORMATION, REFERENCE RANGES, DYSFUNCTION",
author = "Skaarup, {Kristoffer Grundtvig} and Lassen, {Mats Christian H{\o}jbjerg} and Johansen, {Niklas Dyrby} and Olsen, {Flemming Javier} and Lind, {Jannie N{\o}rgaard} and J{\o}rgensen, {Peter Godsk} and Gorm Jensen and Peter Schnohr and Eva Prescott and Peter S{\o}gaard and Rasmus M{\o}gelvang and Tor Biering-S{\o}rensen",
year = "2022",
doi = "10.1093/ehjci/jeab032",
language = "English",
volume = "23",
pages = "629–640",
journal = "European Heart Journal Cardiovascular Imaging",
issn = "2047-2404",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Age- and sex-based normal values of layer-specific longitudinal and circumferential strain by speckle tracking echocardiography

T2 - the Copenhagen City Heart Study

AU - Skaarup, Kristoffer Grundtvig

AU - Lassen, Mats Christian Højbjerg

AU - Johansen, Niklas Dyrby

AU - Olsen, Flemming Javier

AU - Lind, Jannie Nørgaard

AU - Jørgensen, Peter Godsk

AU - Jensen, Gorm

AU - Schnohr, Peter

AU - Prescott, Eva

AU - Søgaard, Peter

AU - Møgelvang, Rasmus

AU - Biering-Sørensen, Tor

PY - 2022

Y1 - 2022

N2 - Aims Technical advancements in 2D-speckle tracking echocardiography (2DSTE) have allowed for quantification of layer-specific global longitudinal strain (GLS) and circumferential strain (GCS) of the left ventricle (LV). The aim of this study was to establish age- and sex-based reference ranges of peak systolic layer-specific GLS and GCS and to assess normal values of regional strain. Methods and results We performed 2DSTE analysis of 1997 members of the general population from the fifth round of the Copenhagen City Heart Study, who were free of cardiovascular disease and risk factors. The mean age was 46 +/- 16 years (range 21-97) and 62% were female. Mean values for peak systolic whole wall GLS (GLS(WW.Sys)), endomycardial (GLS(Endo.Sys)), and epimyocardial (GLS(Epi.Sys)) were 19.9 +/- 2.1% (prediction interval [PI]: 15.8-24.0%), 23.5 +/- 2.5% (PI: 18.6-28.4%), and 17.3 +/- 1.9% (PI: 13.6-21.1%), respectively. Mean peak systolic whole wall GCS (GCS(WW.Sys)), was 21.6 +/- 3.7% (PI: 14.3-28.9%), endomyocardial (GCS(Endo.Sys)) was 31.9 +/- 4.7% (PI: 22.7-41.1%), and epimyocardial (GCS(Epi.Sys)) was 14.3 +/- 3.8% (PI: 6.8-21.8%). A significant discrepancy in normal strain values between males and females was observed. Men had lower mean values and lower reference limits for all strain parameters. Furthermore, GLS and GCS changed differently with age in males and females. Finally, regional LS decreased from the apical to the basal LV region in both sexes, and regional CS varied significantly by LV segment. Conclusion In this study, we reported age- and sex-based reference ranges of layer-specific GLS and GCS. These reference ranges varied significantly with sex and age.

AB - Aims Technical advancements in 2D-speckle tracking echocardiography (2DSTE) have allowed for quantification of layer-specific global longitudinal strain (GLS) and circumferential strain (GCS) of the left ventricle (LV). The aim of this study was to establish age- and sex-based reference ranges of peak systolic layer-specific GLS and GCS and to assess normal values of regional strain. Methods and results We performed 2DSTE analysis of 1997 members of the general population from the fifth round of the Copenhagen City Heart Study, who were free of cardiovascular disease and risk factors. The mean age was 46 +/- 16 years (range 21-97) and 62% were female. Mean values for peak systolic whole wall GLS (GLS(WW.Sys)), endomycardial (GLS(Endo.Sys)), and epimyocardial (GLS(Epi.Sys)) were 19.9 +/- 2.1% (prediction interval [PI]: 15.8-24.0%), 23.5 +/- 2.5% (PI: 18.6-28.4%), and 17.3 +/- 1.9% (PI: 13.6-21.1%), respectively. Mean peak systolic whole wall GCS (GCS(WW.Sys)), was 21.6 +/- 3.7% (PI: 14.3-28.9%), endomyocardial (GCS(Endo.Sys)) was 31.9 +/- 4.7% (PI: 22.7-41.1%), and epimyocardial (GCS(Epi.Sys)) was 14.3 +/- 3.8% (PI: 6.8-21.8%). A significant discrepancy in normal strain values between males and females was observed. Men had lower mean values and lower reference limits for all strain parameters. Furthermore, GLS and GCS changed differently with age in males and females. Finally, regional LS decreased from the apical to the basal LV region in both sexes, and regional CS varied significantly by LV segment. Conclusion In this study, we reported age- and sex-based reference ranges of layer-specific GLS and GCS. These reference ranges varied significantly with sex and age.

KW - 2D-speckle tracking echocardiography

KW - layer-specific global longitudinal strain

KW - layer-specific global circumferential strain

KW - normal values

KW - MYOCARDIAL DEFORMATION

KW - REFERENCE RANGES

KW - DYSFUNCTION

U2 - 10.1093/ehjci/jeab032

DO - 10.1093/ehjci/jeab032

M3 - Journal article

C2 - 33624014

VL - 23

SP - 629

EP - 640

JO - European Heart Journal Cardiovascular Imaging

JF - European Heart Journal Cardiovascular Imaging

SN - 2047-2404

IS - 5

ER -

ID: 302813817