Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. A placebo-controlled study

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K B Madsen, C Askov-Hansen, R M Naimi, C F Brandt, B Hartmann, Jens Juul Holst, P B Mortensen, P B Jeppesen

The ileocolonic brake is impaired in short bowel syndrome (SBS) patients with distal bowel resections. An attenuated meal-stimulated hormone secretion may cause gastric hypersecretion, rapid gastric and intestinal transit and a poor adaptation. Attempting to restore this ileocolonic brake, this study evaluated the acute effects of continuous intravenous administration of glucagon-like peptide (GLP) 1 and 2, alone or in combination, on gastrointestinal function in SBS patients.
Original languageEnglish
JournalRegulatory Peptides
Volume184
Issue number10
Pages (from-to)30-9
Number of pages10
ISSN0167-0115
DOIs
Publication statusPublished - 10 Jun 2013

ID: 45839908