A systematic review and meta-analysis finds increased blood levels of all forms of ghrelin in both restricting and binge-eating/purging subtypes of anorexia nervosa
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A systematic review and meta-analysis finds increased blood levels of all forms of ghrelin in both restricting and binge-eating/purging subtypes of anorexia nervosa. / Seidel, Maria; Jensen, Signe Markmann; Healy, Darren; Dureja, Aakriti; Watson, Hunna J.; Holst, Birgitte; Bulik, Cynthia M.; Sjögren, Jan Magnus.
In: Nutrients, Vol. 13, No. 2, 709, 2021, p. 1-19.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - A systematic review and meta-analysis finds increased blood levels of all forms of ghrelin in both restricting and binge-eating/purging subtypes of anorexia nervosa
AU - Seidel, Maria
AU - Jensen, Signe Markmann
AU - Healy, Darren
AU - Dureja, Aakriti
AU - Watson, Hunna J.
AU - Holst, Birgitte
AU - Bulik, Cynthia M.
AU - Sjögren, Jan Magnus
PY - 2021
Y1 - 2021
N2 - Anorexia nervosa (AN) is a severe psychiatric condition associated with high mortality and chronicity. The hunt for state, trait, subtyping, and prognostic biomarkers is ongoing and the orexigenic hormone ghrelin and its different forms, acyl ghrelin and desacyl ghrelin, have been proposed to be increased in AN, especially in the restrictive subtype. A systematic literature search was performed using established databases up to 30 November 2020. Forty-nine studies met inclusion criteria for cross-sectional and longitudinal meta-analyses on total ghrelin, acyl ghrelin, and desacyl ghrelin. All forms of ghrelin were increased in the acute stage of anorexia nervosa during fasting compared to healthy controls. Previous notions on differences in ghrelin levels between AN subtypes were not supported by current data. In addition, a significant decrease in total ghrelin was observed pre-treatment to follow-up. However, total ghrelin levels at follow-up were still margin-ally elevated compared to healthy controls, whereas for acyl ghrelin, no overall effect of treatment was observed. Due to heterogeneity in follow-up designs and only few data on long-term recovered patients, longitudinal results should be interpreted with caution. While the first steps towards a biomarker in acute AN have been completed, the value of ghrelin as a potential indicator of treatment success or recovery status or its use in subtype differentiation are yet to be established.
AB - Anorexia nervosa (AN) is a severe psychiatric condition associated with high mortality and chronicity. The hunt for state, trait, subtyping, and prognostic biomarkers is ongoing and the orexigenic hormone ghrelin and its different forms, acyl ghrelin and desacyl ghrelin, have been proposed to be increased in AN, especially in the restrictive subtype. A systematic literature search was performed using established databases up to 30 November 2020. Forty-nine studies met inclusion criteria for cross-sectional and longitudinal meta-analyses on total ghrelin, acyl ghrelin, and desacyl ghrelin. All forms of ghrelin were increased in the acute stage of anorexia nervosa during fasting compared to healthy controls. Previous notions on differences in ghrelin levels between AN subtypes were not supported by current data. In addition, a significant decrease in total ghrelin was observed pre-treatment to follow-up. However, total ghrelin levels at follow-up were still margin-ally elevated compared to healthy controls, whereas for acyl ghrelin, no overall effect of treatment was observed. Due to heterogeneity in follow-up designs and only few data on long-term recovered patients, longitudinal results should be interpreted with caution. While the first steps towards a biomarker in acute AN have been completed, the value of ghrelin as a potential indicator of treatment success or recovery status or its use in subtype differentiation are yet to be established.
KW - Acyl ghrelin
KW - Anorexia nervosa
KW - Desacyl ghrelin
KW - Eating disorders
KW - Ghrelin
KW - Meta-analysis
KW - Systematic re-view
U2 - 10.3390/nu13020709
DO - 10.3390/nu13020709
M3 - Review
C2 - 33672297
AN - SCOPUS:85101191603
VL - 13
SP - 1
EP - 19
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 709
ER -
ID: 257972205