A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning
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A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning. / Nilsson, Anne C; Östman, Elin M; Knudsen, Knud Erik Bach; Holst, Jens Juul; Björck, Inger M E.
In: Journal of Nutrition, Vol. 140, No. 11, 01.11.2010, p. 1932-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning
AU - Nilsson, Anne C
AU - Östman, Elin M
AU - Knudsen, Knud Erik Bach
AU - Holst, Jens Juul
AU - Björck, Inger M E
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Epidemiological studies have shown an inverse relation between a whole grain consumption and risk of type-2 diabetes and cardiovascular disease. One tentative mechanism relates to colonic metabolism of indigestible carbohydrates. In a previous study, we reported a positive relation between colonic fermentation and improved glucose tolerance. This work can be seen as an extension of that study, focusing on the tentative role of specific colonic metabolites, i.e. SCFA. Plasma concentrations of acetate, propionate, and butyrate were determined in the morning in healthy participants (5 women and 10 men, mean ± SD: 25.9 ± 3.2 y, BMI <25) following 8 different cereal-based evening meals (50 g available starch) varying in content of indigestible carbohydrates. Each participant consumed all test meals in a random order on separate evenings. At a standardized breakfast following evening test meals, the postprandial glucose response (incremental area under the curve, 0-120 min) was inversely related to plasma butyrate (r = -0.26; P <0.01) and acetate (r = -0.20; P <0.05) concentrations. Evening meals composed of high-amylose barley kernels or high-ß-glucan barley kernels resulted in higher plasma butyrate concentrations the following morning compared with an evening meal with white wheat bread (P <0.05). The results support the view that cereal products rich in indigestible carbohydrates may improve glucose tolerance through a mechanism involving colonic fermentation and generation of SCFA, where in particular butyric acid may be involved. This mechanism may be one explanation by which whole grain is protective against type 2 diabetes and cardiovascular disease.
AB - Epidemiological studies have shown an inverse relation between a whole grain consumption and risk of type-2 diabetes and cardiovascular disease. One tentative mechanism relates to colonic metabolism of indigestible carbohydrates. In a previous study, we reported a positive relation between colonic fermentation and improved glucose tolerance. This work can be seen as an extension of that study, focusing on the tentative role of specific colonic metabolites, i.e. SCFA. Plasma concentrations of acetate, propionate, and butyrate were determined in the morning in healthy participants (5 women and 10 men, mean ± SD: 25.9 ± 3.2 y, BMI <25) following 8 different cereal-based evening meals (50 g available starch) varying in content of indigestible carbohydrates. Each participant consumed all test meals in a random order on separate evenings. At a standardized breakfast following evening test meals, the postprandial glucose response (incremental area under the curve, 0-120 min) was inversely related to plasma butyrate (r = -0.26; P <0.01) and acetate (r = -0.20; P <0.05) concentrations. Evening meals composed of high-amylose barley kernels or high-ß-glucan barley kernels resulted in higher plasma butyrate concentrations the following morning compared with an evening meal with white wheat bread (P <0.05). The results support the view that cereal products rich in indigestible carbohydrates may improve glucose tolerance through a mechanism involving colonic fermentation and generation of SCFA, where in particular butyric acid may be involved. This mechanism may be one explanation by which whole grain is protective against type 2 diabetes and cardiovascular disease.
KW - Adult
KW - Amylose
KW - Blood Glucose
KW - Butyrates
KW - Cereals
KW - Cross-Over Studies
KW - Dietary Carbohydrates
KW - Dietary Fiber
KW - Fatty Acids, Volatile
KW - Feeding Behavior
KW - Female
KW - Glucose Intolerance
KW - Hordeum
KW - Humans
KW - Male
KW - Seeds
KW - Starch
KW - Time Factors
KW - Young Adult
KW - beta-Glucans
U2 - 10.3945/jn.110.123604
DO - 10.3945/jn.110.123604
M3 - Journal article
C2 - 20810606
VL - 140
SP - 1932
EP - 1936
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 11
ER -
ID: 33939197