[68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

[68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy. / Follin, Bjarke; Hoeeg, Cecilie; Hunter, Ingrid; Bentsen, Simon; Juhl, Morten; Jensen, Jacob Kildevang; Binderup, Tina; Nielsen, Carsten Haagen; Ripa, Rasmus Sejersten; Kastrup, Jens; Ekblond, Annette; Kjaer, Andreas.

In: Diagnostics, Vol. 13, No. 2, 268, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Follin, B, Hoeeg, C, Hunter, I, Bentsen, S, Juhl, M, Jensen, JK, Binderup, T, Nielsen, CH, Ripa, RS, Kastrup, J, Ekblond, A & Kjaer, A 2023, '[68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy', Diagnostics, vol. 13, no. 2, 268. https://doi.org/10.3390/diagnostics13020268

APA

Follin, B., Hoeeg, C., Hunter, I., Bentsen, S., Juhl, M., Jensen, J. K., Binderup, T., Nielsen, C. H., Ripa, R. S., Kastrup, J., Ekblond, A., & Kjaer, A. (2023). [68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy. Diagnostics, 13(2), [268]. https://doi.org/10.3390/diagnostics13020268

Vancouver

Follin B, Hoeeg C, Hunter I, Bentsen S, Juhl M, Jensen JK et al. [68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy. Diagnostics. 2023;13(2). 268. https://doi.org/10.3390/diagnostics13020268

Author

Follin, Bjarke ; Hoeeg, Cecilie ; Hunter, Ingrid ; Bentsen, Simon ; Juhl, Morten ; Jensen, Jacob Kildevang ; Binderup, Tina ; Nielsen, Carsten Haagen ; Ripa, Rasmus Sejersten ; Kastrup, Jens ; Ekblond, Annette ; Kjaer, Andreas. / [68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy. In: Diagnostics. 2023 ; Vol. 13, No. 2.

Bibtex

@article{65cd875088b84c0791321c6f873cb294,
title = "[68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy",
abstract = "An increasing number of patients are living with chronic ischemic cardiomyopathy (ICM) and/or heart failure. Treatment options and prognostic tools are lacking for many of these patients. Our aim was to investigate the prognostic value of imaging angiogenesis and macrophage activation via positron emission tomography (PET) in terms of functional improvement after cell therapy. Myocardial infarction was induced in rats. Animals were scanned with [18F]FDG PET and echocardiography after four weeks and randomized to allogeneic adipose tissue-derived stromal cells (ASCs, n = 18) or saline (n = 9). Angiogenesis and macrophage activation were assessed before and after treatment by [68Ga]Ga-RGD and [64Cu]Cu-DOTATATE. There was no overall effect of the treatment. Rats that improved left ventricular ejection fraction (LVEF) had higher uptake of both [68Ga]Ga-RGD and [64Cu]Cu-DOTATATE at follow-up (p = 0.006 and p = 0.008, respectively). The uptake of the two tracers correlated with each other (r = 0.683, p = 0.003 pre-treatment and r = 0.666, p = 0.004 post-treatment). SUVmax at follow-up could predict improvement in LVEF (p = 0.016 for [68Ga]Ga-RGD and p = 0.045 for [64Cu]Cu-DOTATATE). High uptake of [68Ga]Ga-RGD and [64Cu]Cu-DOTATATE PET after injection of ASCs or saline preceded improvement in LVEF. The use of these tracers could improve the monitoring of heart failure patients in treatment.",
keywords = "angiogenesis, cardiomyopathy, cell therapy, inflammation, nuclear cardiology",
author = "Bjarke Follin and Cecilie Hoeeg and Ingrid Hunter and Simon Bentsen and Morten Juhl and Jensen, {Jacob Kildevang} and Tina Binderup and Nielsen, {Carsten Haagen} and Ripa, {Rasmus Sejersten} and Jens Kastrup and Annette Ekblond and Andreas Kjaer",
note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",
year = "2023",
doi = "10.3390/diagnostics13020268",
language = "English",
volume = "13",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - [68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy

AU - Follin, Bjarke

AU - Hoeeg, Cecilie

AU - Hunter, Ingrid

AU - Bentsen, Simon

AU - Juhl, Morten

AU - Jensen, Jacob Kildevang

AU - Binderup, Tina

AU - Nielsen, Carsten Haagen

AU - Ripa, Rasmus Sejersten

AU - Kastrup, Jens

AU - Ekblond, Annette

AU - Kjaer, Andreas

N1 - Publisher Copyright: © 2023 by the authors.

PY - 2023

Y1 - 2023

N2 - An increasing number of patients are living with chronic ischemic cardiomyopathy (ICM) and/or heart failure. Treatment options and prognostic tools are lacking for many of these patients. Our aim was to investigate the prognostic value of imaging angiogenesis and macrophage activation via positron emission tomography (PET) in terms of functional improvement after cell therapy. Myocardial infarction was induced in rats. Animals were scanned with [18F]FDG PET and echocardiography after four weeks and randomized to allogeneic adipose tissue-derived stromal cells (ASCs, n = 18) or saline (n = 9). Angiogenesis and macrophage activation were assessed before and after treatment by [68Ga]Ga-RGD and [64Cu]Cu-DOTATATE. There was no overall effect of the treatment. Rats that improved left ventricular ejection fraction (LVEF) had higher uptake of both [68Ga]Ga-RGD and [64Cu]Cu-DOTATATE at follow-up (p = 0.006 and p = 0.008, respectively). The uptake of the two tracers correlated with each other (r = 0.683, p = 0.003 pre-treatment and r = 0.666, p = 0.004 post-treatment). SUVmax at follow-up could predict improvement in LVEF (p = 0.016 for [68Ga]Ga-RGD and p = 0.045 for [64Cu]Cu-DOTATATE). High uptake of [68Ga]Ga-RGD and [64Cu]Cu-DOTATATE PET after injection of ASCs or saline preceded improvement in LVEF. The use of these tracers could improve the monitoring of heart failure patients in treatment.

AB - An increasing number of patients are living with chronic ischemic cardiomyopathy (ICM) and/or heart failure. Treatment options and prognostic tools are lacking for many of these patients. Our aim was to investigate the prognostic value of imaging angiogenesis and macrophage activation via positron emission tomography (PET) in terms of functional improvement after cell therapy. Myocardial infarction was induced in rats. Animals were scanned with [18F]FDG PET and echocardiography after four weeks and randomized to allogeneic adipose tissue-derived stromal cells (ASCs, n = 18) or saline (n = 9). Angiogenesis and macrophage activation were assessed before and after treatment by [68Ga]Ga-RGD and [64Cu]Cu-DOTATATE. There was no overall effect of the treatment. Rats that improved left ventricular ejection fraction (LVEF) had higher uptake of both [68Ga]Ga-RGD and [64Cu]Cu-DOTATATE at follow-up (p = 0.006 and p = 0.008, respectively). The uptake of the two tracers correlated with each other (r = 0.683, p = 0.003 pre-treatment and r = 0.666, p = 0.004 post-treatment). SUVmax at follow-up could predict improvement in LVEF (p = 0.016 for [68Ga]Ga-RGD and p = 0.045 for [64Cu]Cu-DOTATATE). High uptake of [68Ga]Ga-RGD and [64Cu]Cu-DOTATATE PET after injection of ASCs or saline preceded improvement in LVEF. The use of these tracers could improve the monitoring of heart failure patients in treatment.

KW - angiogenesis

KW - cardiomyopathy

KW - cell therapy

KW - inflammation

KW - nuclear cardiology

UR - http://www.scopus.com/inward/record.url?scp=85146785566&partnerID=8YFLogxK

U2 - 10.3390/diagnostics13020268

DO - 10.3390/diagnostics13020268

M3 - Journal article

C2 - 36673078

AN - SCOPUS:85146785566

VL - 13

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 2

M1 - 268

ER -

ID: 334855924