18F-FET-PET in Primary Hyperparathyroidism: A Pilot Study

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Standard

18F-FET-PET in Primary Hyperparathyroidism : A Pilot Study. / Krakauer, Martin; Kjær, Andreas; Bennedbæk, Finn Noe.

In: Diagnostics, Vol. 6, No. 3, 30, 2016.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Harvard

Krakauer, M, Kjær, A & Bennedbæk, FN 2016, '18F-FET-PET in Primary Hyperparathyroidism: A Pilot Study', Diagnostics, vol. 6, no. 3, 30. https://doi.org/10.3390/diagnostics6030030

APA

Krakauer, M., Kjær, A., & Bennedbæk, F. N. (2016). 18F-FET-PET in Primary Hyperparathyroidism: A Pilot Study. Diagnostics, 6(3), [30]. https://doi.org/10.3390/diagnostics6030030

Vancouver

Krakauer M, Kjær A, Bennedbæk FN. 18F-FET-PET in Primary Hyperparathyroidism: A Pilot Study. Diagnostics. 2016;6(3). 30. https://doi.org/10.3390/diagnostics6030030

Author

Krakauer, Martin ; Kjær, Andreas ; Bennedbæk, Finn Noe. / 18F-FET-PET in Primary Hyperparathyroidism : A Pilot Study. In: Diagnostics. 2016 ; Vol. 6, No. 3.

Bibtex

@article{2fcce5cccc3e49f1b9823c8868a2f5b7,
title = "18F-FET-PET in Primary Hyperparathyroidism: A Pilot Study",
abstract = "Preoperative localisation of the diseased parathyroid gland(s) in primary hyperparathyroidism (PHP) is a prerequisite for subsequent minimally invasive surgery. Recently, as alternatives to conventional sestamibi parathyroid scintigraphy, the (11)C-based positron emission tomography (PET) tracers methionine and choline have shown promise for this purpose. We evaluated the feasibility of using the (18)F-based PET tracer fluoroethyl-l-tyrosine (FET), as the longer half-life of (18)F makes it logistically more favourable. As a proof-of-concept study, we included two patients with PHP in which dual-isotope parathyroid subtraction single photon emission computed tomography had determined the exact location of the parathyroid adenoma. A dynamic FET PET/CT scan was performed with subsequent visual evaluation and calculation of target-to-background (TBR; parathyroid vs. thyroid). The maximum TBR in the two patients under study was achieved approximately 30 min after the injection of the tracer and was 1.5 and 1.7, respectively. This ratio was too small to allow for confident visualisation of the adenomas. FET PET/CT seems not feasible as a preoperative imaging modality in PHP.",
author = "Martin Krakauer and Andreas Kj{\ae}r and Bennedb{\ae}k, {Finn Noe}",
year = "2016",
doi = "10.3390/diagnostics6030030",
language = "English",
volume = "6",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "MDPI AG",
number = "3",

}

RIS

TY - JOUR

T1 - 18F-FET-PET in Primary Hyperparathyroidism

T2 - A Pilot Study

AU - Krakauer, Martin

AU - Kjær, Andreas

AU - Bennedbæk, Finn Noe

PY - 2016

Y1 - 2016

N2 - Preoperative localisation of the diseased parathyroid gland(s) in primary hyperparathyroidism (PHP) is a prerequisite for subsequent minimally invasive surgery. Recently, as alternatives to conventional sestamibi parathyroid scintigraphy, the (11)C-based positron emission tomography (PET) tracers methionine and choline have shown promise for this purpose. We evaluated the feasibility of using the (18)F-based PET tracer fluoroethyl-l-tyrosine (FET), as the longer half-life of (18)F makes it logistically more favourable. As a proof-of-concept study, we included two patients with PHP in which dual-isotope parathyroid subtraction single photon emission computed tomography had determined the exact location of the parathyroid adenoma. A dynamic FET PET/CT scan was performed with subsequent visual evaluation and calculation of target-to-background (TBR; parathyroid vs. thyroid). The maximum TBR in the two patients under study was achieved approximately 30 min after the injection of the tracer and was 1.5 and 1.7, respectively. This ratio was too small to allow for confident visualisation of the adenomas. FET PET/CT seems not feasible as a preoperative imaging modality in PHP.

AB - Preoperative localisation of the diseased parathyroid gland(s) in primary hyperparathyroidism (PHP) is a prerequisite for subsequent minimally invasive surgery. Recently, as alternatives to conventional sestamibi parathyroid scintigraphy, the (11)C-based positron emission tomography (PET) tracers methionine and choline have shown promise for this purpose. We evaluated the feasibility of using the (18)F-based PET tracer fluoroethyl-l-tyrosine (FET), as the longer half-life of (18)F makes it logistically more favourable. As a proof-of-concept study, we included two patients with PHP in which dual-isotope parathyroid subtraction single photon emission computed tomography had determined the exact location of the parathyroid adenoma. A dynamic FET PET/CT scan was performed with subsequent visual evaluation and calculation of target-to-background (TBR; parathyroid vs. thyroid). The maximum TBR in the two patients under study was achieved approximately 30 min after the injection of the tracer and was 1.5 and 1.7, respectively. This ratio was too small to allow for confident visualisation of the adenomas. FET PET/CT seems not feasible as a preoperative imaging modality in PHP.

U2 - 10.3390/diagnostics6030030

DO - 10.3390/diagnostics6030030

M3 - Comment/debate

C2 - 27548229

VL - 6

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 3

M1 - 30

ER -

ID: 173164369