1,4-Anhydro-4-seleno-d-talitol (SeTal): a remarkable selenium-containing therapeutic molecule

Research output: Contribution to journal › Review › Research › peer-review

Standard

1,4-Anhydro-4-seleno-d-talitol (SeTal) : a remarkable selenium-containing therapeutic molecule. / Davies, Michael J.; Schiesser, Carl H.

In: New Journal of Chemistry, Vol. 43, No. 25, 2019, p. 9759-9765.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Davies, MJ & Schiesser, CH 2019, '1,4-Anhydro-4-seleno-d-talitol (SeTal): a remarkable selenium-containing therapeutic molecule', New Journal of Chemistry, vol. 43, no. 25, pp. 9759-9765. https://doi.org/10.1039/c9nj02185j

APA

Davies, M. J., & Schiesser, C. H. (2019). 1,4-Anhydro-4-seleno-d-talitol (SeTal): a remarkable selenium-containing therapeutic molecule. New Journal of Chemistry, 43(25), 9759-9765. https://doi.org/10.1039/c9nj02185j

Vancouver

Davies MJ, Schiesser CH. 1,4-Anhydro-4-seleno-d-talitol (SeTal): a remarkable selenium-containing therapeutic molecule. New Journal of Chemistry. 2019;43(25):9759-9765. https://doi.org/10.1039/c9nj02185j

Author

Davies, Michael J. ; Schiesser, Carl H. / 1,4-Anhydro-4-seleno-d-talitol (SeTal) : a remarkable selenium-containing therapeutic molecule. In: New Journal of Chemistry. 2019 ; Vol. 43, No. 25. pp. 9759-9765.

Bibtex

@article{5e4484aa725647df8030de71f4af20e6,
title = "1,4-Anhydro-4-seleno-d-talitol (SeTal): a remarkable selenium-containing therapeutic molecule",
abstract = "It is well accepted that organoselenium compounds are powerful antioxidants that have potential therapeutic benefits. Unfortunately, the therapeutic value of many of these selenium-containing entities is often hampered by low solubility in aqueous solutions, which prevents them from reaching therapeutically relevant doses in plasma. We approached this problem by constructing selenosugars with infinite water solubilities. Work over many years led to the discovery of 1,4-anhydro-4-seleno-d-tallitol (SeTal), which has been shown to accelerate skin-tissue repair, heal wounds in (db/db and wt) rodent and porcine models, and prevent high-glucose-induced endothelial dysfunction in mouse aorta. This lead compound is currently being developed as a topical medicament for a variety of skin-repair scenarios. This article discusses the chemistry that led to the development of our selenium-containing carbohydrates, and showcases the remarkable therapeutic properties of SeTal.",
author = "Davies, {Michael J.} and Schiesser, {Carl H.}",
year = "2019",
doi = "10.1039/c9nj02185j",
language = "English",
volume = "43",
pages = "9759--9765",
journal = "New Journal of Chemistry",
issn = "1144-0546",
publisher = "Royal Society of Chemistry",
number = "25",

}

RIS

TY - JOUR

T1 - 1,4-Anhydro-4-seleno-d-talitol (SeTal)

T2 - a remarkable selenium-containing therapeutic molecule

AU - Davies, Michael J.

AU - Schiesser, Carl H.

PY - 2019

Y1 - 2019

N2 - It is well accepted that organoselenium compounds are powerful antioxidants that have potential therapeutic benefits. Unfortunately, the therapeutic value of many of these selenium-containing entities is often hampered by low solubility in aqueous solutions, which prevents them from reaching therapeutically relevant doses in plasma. We approached this problem by constructing selenosugars with infinite water solubilities. Work over many years led to the discovery of 1,4-anhydro-4-seleno-d-tallitol (SeTal), which has been shown to accelerate skin-tissue repair, heal wounds in (db/db and wt) rodent and porcine models, and prevent high-glucose-induced endothelial dysfunction in mouse aorta. This lead compound is currently being developed as a topical medicament for a variety of skin-repair scenarios. This article discusses the chemistry that led to the development of our selenium-containing carbohydrates, and showcases the remarkable therapeutic properties of SeTal.

AB - It is well accepted that organoselenium compounds are powerful antioxidants that have potential therapeutic benefits. Unfortunately, the therapeutic value of many of these selenium-containing entities is often hampered by low solubility in aqueous solutions, which prevents them from reaching therapeutically relevant doses in plasma. We approached this problem by constructing selenosugars with infinite water solubilities. Work over many years led to the discovery of 1,4-anhydro-4-seleno-d-tallitol (SeTal), which has been shown to accelerate skin-tissue repair, heal wounds in (db/db and wt) rodent and porcine models, and prevent high-glucose-induced endothelial dysfunction in mouse aorta. This lead compound is currently being developed as a topical medicament for a variety of skin-repair scenarios. This article discusses the chemistry that led to the development of our selenium-containing carbohydrates, and showcases the remarkable therapeutic properties of SeTal.

U2 - 10.1039/c9nj02185j

DO - 10.1039/c9nj02185j

M3 - Review

VL - 43

SP - 9759

EP - 9765

JO - New Journal of Chemistry

JF - New Journal of Chemistry

SN - 1144-0546

IS - 25

ER -

ID: 223923001