Søren-Peter Olesen

Søren-Peter Olesen

Professor


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  1. Published

    Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells

    Adinolfi, B., Carpi, S., Romanini, A., Da Pozzo, E., Castagna, M., Costa, B., Martini, C., Olesen, Søren-Peter, Schmitt, Nicole, Breschi, M. C., Nieri, P. & Fogli, S., Jul 2015, In: Anticancer Research. 35, 7, p. 3781-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

    Ahlberg, G., Refsgaard, L., Lundegaard, Pia Rengtved, Andreasen, Laura Korsholm, Ranthe, M. F., Linscheid, N., Nielsen, J. B., Melbye, M., Haunsø, Stig, Sajadieh, Ahmad, Camp, L., Olesen, Søren-Peter, Rasmussen, Simon, Lundby, Alicia, Ellinor, P. T., Holst, A. G., Svendsen, Jesper Hastrup & Olesen, Morten Steen Salling, 2018, In: Nature Communications. 9, 1, 11 p., 4316.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    AMP-activated protein kinase downregulates Kv7.1 cell surface expression

    Andersen, M. N., Krzystanek, K., Jespersen, Thomas, Olesen, Søren-Peter & Rasmussen, Hanne Borger, 2012, In: Traffic. 13, 1, p. 143-56 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Kv7.1 surface expression is regulated by epithelial cell polarization

    Andersen, M. N., Olesen, Søren-Peter & Rasmussen, Hanne Borger, 2011, In: American Journal of Physiology: Cell Physiology. 300, 4, p. C814-24

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking

    Andersen, M. N., Hefting, L. L., Steffensen, Annette Buur, Schmitt, Nicole, Olesen, Søren-Peter, Olsen, Jesper Velgaard, Lundby, Alicia & Rasmussen, Hanne Borger, 15 Nov 2015, In: American Journal of Physiology: Cell Physiology. 309, 10, p. C693-C706 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

    Andersen, M. N., Krzystanek, K., Petersen, F., Bomholtz, Sofia Hammami, Olesen, Søren-Peter, Abriel, H., Jespersen, Thomas & Rasmussen, Hanne Borger, 8 Nov 2013, In: The Journal of Biological Chemistry. 288, 52, p. 36841-54 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.

    Angelo, K., Jespersen, Thomas, Grunnet, Morten, Nielsen, Morten Schak, Klærke, Dan Arne & Olesen, Søren-Peter, 2002, In: Biophysical Journal. 83, 4, p. 1997-2006 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1.

    Angelo, K., Korolkova, Y. V., Grunnet, Morten, Grishin, E. V., Pluzhnikov, K. A., Klærke, Dan Arne, Knaus, H., Møller, Morten & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 447, 1, p. 55-63 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension

    Askew Page, H. R., Dalsgaard, T., Baldwin, S. N., Jepps, Thomas Andrew Qvistgaard, Povstyan, O., Olesen, Søren-Peter & Greenwood, I. A., Jun 2019, In: British Journal of Pharmacology. 176, 11, p. 1635-1648

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production

    Bang, L., Nielsen-Kudsk, J. E., Gruhn, N., Theilgaard, S. A., Olesen, Søren-Peter & Aldershvile, J., 1999, In: Scandinavian Cardiovascular Journal. 33, p. 71-78

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Hydralazine-induced vasodilation involves opening of high conductan Ca2+-activated K+ channels

    Bang, L., Nielsen-Kudsk, J. E., Gruhn, N., Trautner, S., Theilgaard, S. A., Olesen, Søren-Peter, Boesgaard, S. & Aldershvile, J., 1998, In: European Journal of Pharmacology. 361(1), p. 43-49

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Live Imaging of Kv7.2/7.3 Cell Surface Dynamics at the Axon Initial Segment: High Steady-State Stability and Calpain-Dependent Excitotoxic Downregulation Revealed.

    Benned-Jensen, T., Christensen, R. K., Denti, F., Perrier, Jean-Francois Marie, Rasmussen, Hanne Borger & Olesen, Søren-Peter, 2016, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 36, 7, p. 2261-2266

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    BK channel activators and their therapeutic perspectives

    Bentzen, Bo Hjorth, Olesen, Søren-Peter, Rønn, L. C. B. & Grunnet, Morten, 2014, In: Frontiers in Physiology. 5, p. 1-12 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury

    Bentzen, Bo Hjorth, Osadchii, O., Jespersen, Thomas, Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2009, In: Pflügers Archiv: European Journal of Physiology. 457, 5, p. 979-88 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.

    Bentzen, Bo Hjorth, Schmitt, Nicole, Callø, Kirstine, Dalby Brown, W., Grunnet, Morten & Olesen, Søren-Peter, 2006, In: Neuropharmacology. 51, 6, p. 1068-77 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.

    Bentzen, Bo Hjorth, Nardi, A., Callø, Kirstine, Madsen, L. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Molecular Pharmacology. 72, 4, p. 1033-44 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo

    Bentzen, Bo Hjorth, Andersen, R. W., Olesen, Søren-Peter, Grunnet, Morten & Nardi, A., 2009, In: NAUNYN-SCHMIEDEBERGS ARCHIV FUR EXPERIMENTELLE PATHOLOGIE UND PHARMAKOLOGIE.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.

    Callø, Kirstine, Ravn, L. S., Schmitt, Nicole, Sui, J. L., Duno, M., Haunso, S., Grunnet, Morten, Svendsen, J. H. & Olesen, Søren-Peter, 2007, In: Biochemical and Biophysical Research Communications. 364, 4, p. 889-95 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome

    Callø, Kirstine, Cordeiro, J. M., Di Diego, J. M., Hansen, R. S., Grunnet, Morten, Olesen, Søren-Peter & Antzelevitch, C., 2008, In: Cardiovascular Research. 81, 4, p. 686-94 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Differential effects of the transient outward K(+) current activator NS5806 in the canine left ventricle

    Callø, Kirstine, Soltysinska, E., Jespersen, Thomas, Lundby, Alicia, Antzelevitch, C., Olesen, Søren-Peter & Cordeiro, J. M., 2009, In: Journal of Molecular and Cellular Cardiology. 48, 1, p. 191-200 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.

    Callø, Kirstine, Elmedyb, P., Olesen, Søren-Peter, Jorgensen, N. K. & Grunnet, Morten, 2005, In: Biophysical Journal. 89, 3, p. 2159-69 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Comparison of the Effects of a Transient Outward Potassium Channel Activator on Currents Recorded from Atrial and Ventricular Cardiomyocytes.

    Callø, Kirstine, Nof, E., Jespersen, Thomas, Di Diego, J. M., Chlus, N., Olesen, Søren-Peter, Antzelevitch, C. & Cordeiro, J. M., 2011, In: Journal of Cardiovascular Electrophysiology. 22, 9, p. 1057-1066 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Tissue-specific effects of acetylcholine in the canine heart

    Callø, Kirstine, Goodrow, R., Olesen, Søren-Peter, Antzelevitch, C. & Cordeiro, J. M., 2013, In: A J P: Heart and Circulatory Physiology (Online). 305, p. H66-H75 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Mechanism of action of NS1643, a novel hERG channel activator

    Casis, O., Olesen, Søren-Peter & Sanguinetti, M. C., 2006, In: Molecular Pharmacology. 69, p. 658-665

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Mechanism of action of a novel human ether-a-go-go-related gene channel activator.

    Casis, O., Olesen, Søren-Peter & Sanguinetti, M. C., 2005, In: Molecular Pharmacology. 69, 2, p. 658-65 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired ß-adrenoceptor-mediated relaxation of renal arteries in hypertension

    Chadha, P. S., Zunke, F., Zhu, H., Davis, A. J., Jepps, Thomas Andrew Qvistgaard, Olesen, Søren-Peter, Cole, W. C., Moffatt, J. D. & Greenwood, I., 2012, In: Hypertension. 59, 4, p. 877-84 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size

    Christensen, A. H., Chatelain, F. C., Huttner, I. G., Olesen, Morten Steen Salling, Soka, M., Feliciangeli, S., Horvat, C., Santiago, C. F., Vandenberg, J. I., Schmitt, Nicole, Olesen, Søren-Peter, Lesage, F. & Fatkin, D., Aug 2016, In: Journal of Molecular and Cellular Cardiology. 97, p. 24-35 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation

    Christophersen, I. E., Olesen, M. S., Liang, B., Andersen, M. N., Larsen, A. P., Nielsen, J. B., Haunsø, Stig, Olesen, Søren-Peter, Tveit, A., Svendsen, Jesper Hastrup & Schmitt, Nicole, 21 Dec 2012, In: European Heart Journal.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Physiological consequences of transient outward K(+) current activation during heart failure in the canine left ventricle

    Cordeiro, J. M., Callø, Kirstine, Moise, N. S., Kornreich, B., Giannandrea, D., Di Diego, J. M., Olesen, Søren-Peter & Antzelevitch, C., 2012, In: Journal of Molecular and Cellular Cardiology. 52, 6, p. 1291-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    K(v)7 channels: Function, pharmacology and channel modulators

    Dalby-Brown, W., Hansen, H. H., Korsgaard, M. P. G., Mirza, N. & Olesen, Søren-Peter, 2006, In: Current Topics in Medicinal Chemistry. 6, 10, p. 999-1023 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Trafficking of the IKs -Complex in MDCK Cells: Site of Subunit Assembly and Determinants of Polarized Localization

    David, J., Andersen, M. N., Olesen, Søren-Peter, Rasmussen, Hanne Borger & Schmitt, Nicole, Apr 2013, In: Traffic. 14, 4, p. 399-411 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation

    Denti, F., Paludan-Müller, Christian, Olesen, Søren-Peter, Haunsø, Stig, Svendsen, Jesper Hastrup, Olesen, Morten Steen Salling, Bentzen, Bo Hjorth & Schmitt, Nicole, Mar 2018, In: Personalized Medicine. 15, 2, p. 93-102 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs

    Diness, Jonas Goldin, Skibsbye, L., Simó-Vicens, R., Louro Larupa dos Santos, J., Lundegaard, Pia Rengtved, Citerni, C., Sauter, D. R. P., Bomholtz, Sofia Hammami, Svendsen, Jesper Hastrup, Olesen, Søren-Peter, Sørensen, U. S., Jespersen, Thomas, Grunnet, Morten & Bentzen, Bo Hjorth, 10 Oct 2017, In: Circulation: Arrhythmia and Electrophysiology. 10, 19 p., e005125.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.

    Diness, T. G., Yeh, Y., Qi, X. Y., Chartier, D., Tsuji, Y., Hansen, R. S., Olesen, Søren-Peter, Grunnet, Morten & Nattel, S., 2008, In: Cardiovascular Research. 79, 1, p. 61-69 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels.

    Diness, T. G., Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 4, p. 1224-33 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Effect of beta-adrenoceptor blockers on human ether-a-go-go-related gene (HERG) potassium channels.

    Dupuis, D. S., Klærke, Dan Arne & Olesen, Søren-Peter, 2005, In: Basic & Clinical Pharmacology & Toxicology. 96, 2, p. 123-30 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.

    Dupuis, D. S., Schrøder, R. L., Jespersen, Thomas, Christensen, J. K., Christophersen, P., Jensen, B. S. & Olesen, Søren-Peter, 2002, In: European Journal of Pharmacology. 437, 3, p. 129-37 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Functional properties of human neuronal Kv11 channels

    Einarsen, K., Callø, Kirstine, Grunnet, Morten, Olesen, Søren-Peter & Schmitt, Nicole, 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 689-700 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Activation of ERG2 potassium channels by the diphenylurea NS1643.

    Elmedyb, P., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Neuropharmacology. 53, 2, p. 283-94 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Modulation of ERG channels by XE991.

    Elmedyb, P., Callø, Kirstine, Schmitt, Nicole, Hansen, R. S., Grunnet, Morten & Olesen, Søren-Peter, 2007, In: Basic & Clinical Pharmacology & Toxicology. 100, 5, p. 316-22 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Single-copy insertion of transgenes in Caenorhabditis elegans.

    Frøkjær-Jensen, Christian, Davis, M. W., Hopkins, C. E., Newman, B. J., Thummel, J. M., Olesen, Søren-Peter, Grunnet, Morten & Jorgensen, E. M., 2008, In: Nature Genetics. 40, 11, p. 1375-83 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality

    Ghouse, Jonas, Have, C. T., Skov, M. W., Andreasen, Laura Korsholm, Ahlberg, G., Nielsen, J. B., Skaaby, T., Olesen, Søren-Peter, Grarup, Niels, Linneberg, Allan René, Pedersen, Oluf Borbye, drb459, drb459, Haunsø, Stig, Svendsen, Jesper Hastrup, Hansen, Torben, Kanters, Jørgen K. & Olesen, Morten Steen Salling, May 2017, In: Genetics In Medicine. 19, 5, p. 521-528 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice

    Grubb, Søren, Speerschneider, T., Occhipinti, D., Fiset, C., Olesen, Søren-Peter, Thomsen, Morten Bækgaard & Callø, Kirstine, 2014, In: Journal of Cardiovascular Electrophysiology. 25, 8, p. 896-904 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Preservation of cardiac function by prolonged action potentials in mice deficient of KChIP2

    Grubb, Søren, Aistrup, G. L., Koivumäki, J. T., Speerschneider, T., Gottlieb, Lisa Amalie, Mutsaers, N. A. M., Olesen, Søren-Peter, Callø, Kirstine & Thomsen, Morten Bækgaard, 1 Aug 2015, In: American Journal of Physiology: Heart and Circulatory Physiology. 309, 3, p. H481-H489 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function

    Grunnet, Morten, Diness, T. G., Hansen, R. S. & Olesen, Søren-Peter, 2008, In: Cellular Physiology and Biochemistry. 22, 5-6, p. 611-624 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.

    Grunnet, Morten, Olesen, Søren-Peter, Klærke, Dan Arne & Jespersen, Thomas, 2005, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1146-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    KCNQ1 channels sense small changes in cell volume.

    Grunnet, Morten, Jespersen, Thomas, MacAulay, Nanna, Jørgensen, N. K., Schmitt, Nicole, Pongs, O., Olesen, Søren-Peter & Klærke, Dan Arne, 2003, In: Journal of Physiology. 549, Pt 2, p. 419-27 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Regulation of cloned, Ca2+-activated K+ channels by cell volume changes.

    Grunnet, Morten, MacAulay, Nanna, Jorgensen, N. K., Jensen, S., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Pflügers Archiv: European Journal of Physiology. 444, 1-2, p. 167-77 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome.

    Grunnet, Morten, Behr, E. R., Callø, Kirstine, Hofman-Bang, J., Till, J., Christiansen, M., McKenna, W. J., Olesen, Søren-Peter & Schmitt, Nicole, 2005, In: Heart Rhythm. 2, 11, p. 1238-49 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Apamin interacts with all subtypes of cloned small-conductance Ca2+-activated K+ channels

    Grunnet, Morten, Jensen, B. S., Olesen, Søren-Peter & Klærke, Dan Arne, 2001, In: Pflügers Archiv: European Journal of Physiology. 441, p. 544-550

    Research output: Contribution to journal › Journal article › Research › peer-review

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