Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice
Research output: Contribution to journal › Journal article › Research › peer-review
KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.
| Original language | English |
|---|---|
| Journal | Journal of Cardiovascular Electrophysiology |
| Volume | 25 |
| Issue number | 8 |
| Pages (from-to) | 896-904 |
| Number of pages | 9 |
| DOIs | |
| Publication status | Published - 2014 |
ID: 106948937