Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice

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KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.
Original languageEnglish
JournalJournal of Cardiovascular Electrophysiology
Issue number8
Pages (from-to)896-904
Number of pages9
Publication statusPublished - 2014

ID: 106948937