Olav Larsen

Olav Larsen

Postdoc


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1 - 26 out of 26Page size: 50
  1. 2023
  2. Published

    Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5

    Larsen, Olav, Schuermans, S., Walser, Anna Louise Silvia, Louka, S., Lillethorup, I. A., Våbenø, J., Qvortrup, K., Proost, P. & Rosenkilde, Mette, 2023, In: FEBS Letters. 597, 24, p. 3049-3060

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    GPR162 is a beta cell CART receptor

    Lindqvist, A., Abels, M., Shcherbina, L., Ngara, M., Kryvokhyzha, D., Chriett, S., Riva, M., Fajul, A., Barghouth, M., Luan, C., Eliasson, L., Larsen, Olav, Rosenkilde, Mette, Zhang, E., Renström, E. & Wierup, N., 2023, In: iScience. 26, 12, 15 p., 108416.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2022
  5. Published

    Identification of a conserved chemokine receptor motif that enables ligand discrimination

    Larsen, Olav, van der Velden, W. J. C., Mavri, M., Schuermans, S., Rummel, P. C., Karlshøj, S., Gustavsson, Martin, Proost, P., Våbenø, J. & Rosenkilde, Mette, 2022, In: Science Signaling. 15, 724, eabg7042.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2021
  7. Published

    GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

    van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. 2019
  9. Published

    Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

    Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1

    Larsen, Olav, Lückmann, Michael, van der Velden, W. J. C., Oliva-Santiago, M., Brvar, M., Ulven, Trond, Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 2019, In: ACS Pharmacology & Translational Science. 2, 6, p. 429-441 13 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  11. Published

    Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1

    Fox, J. C., Thomas, M. A., Dishman, A. F., Larsen, Olav, Nakayama, T., Yoshie, O., Rosenkilde, Mette & Volkman, B. F., 2019, In: Science Signaling. 12, 597, 15 p., eaat4128.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2018
  13. Published

    Mutational analysis of CCL20 reveals flexibility of N-terminal amino acid composition and length

    Riutta, S. J., Larsen, Olav, Getschman, A. E., Rosenkilde, M. M., Hwang, S. T. & Volkman, B. F., Aug 2018, In: Journal of Leukocyte Biology. 104, 2, p. 423-434

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Insulin Secretion Depends on Intra-islet Glucagon Signaling

    Svendsen, B., Larsen, Olav, Gabe, M. B. N., Christiansen, Charlotte Bayer, Rosenkilde, M. M., Drucker, D. J. & Holst, Jens Juul, 2018, In: Cell Reports. 25, 5, p. 1127-1134.E2

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity

    Janssens, R., Boff, D., Ruytinx, P., Mortier, A., Vanheule, V., Larsen, Olav, Daugvilaite, V., Rosenkilde, Mette, Noppen, S., Liekens, S., Schols, D., De Meester, I., Opdenakker, G., Struyf, S., Teixeira, M. M., Amaral, F. A. & Proost, P., 2018, In: Frontiers in Immunology. 9, p. 1933

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

    Miles, T. F., Spiess, Katja, Jude, K. M., Tsutsumi, N., Burg, J. S., Ingram, J. R., Waghray, D., Hjortø, Gertrud Malene, Larsen, Olav, Ploegh, H. L., Rosenkilde, Mette & Garcia, K. C., 2018, In: eLife. 7, 23 p., e35850 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2017
  19. Published

    Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration

    González-Motos, V., Jürgens, C., Ritter, B., Kropp, K. A., Durán, V., Larsen, Olav, Binz, A., Ouwendijk, W. J. D., Lenac Rovis, T., Jonjic, S., Verjans, G. M. G. M., Sodeik, B., Krey, T., Bauerfeind, R., Schulz, T. F., Kaufer, B. B., Kalinke, U., Proudfoot, A. E. I., Rosenkilde, Mette & Viejo-Borbolla, A., May 2017, In: PLOS Pathogens. 13, 5, 28 p., e1006346.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23-dependent murine model

    Getschman, A. E., Imai, Y., Larsen, Olav, Peterson, F. C., Wu, X., Rosenkilde, M. M., Hwang, S. T. & Volkman, B. F., 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. 12460-12465 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes

    Janssens, R., Mortier, A., Boff, D., Ruytinx, P., Gouwy, M., Vantilt, B., Larsen, Olav, Daugvilaite, V., Rosenkilde, Mette, Parmentier, M., Noppen, S., Liekens, S., Van Damme, J., Struyf, S., Teixeira, M. M., Amaral, F. A. & Proost, P., 2017, In: Biochemical Pharmacology. 132, p. 92-101 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 2016
  23. Published

    Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

    Karlshøj, S., Amarandi, R. M., Larsen, Olav, Daugvilaite, V., Steen, A., Brvar, M., Pui, A., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 23 Dec 2016, In: Journal of Biological Chemistry. 291, 52, p. 26860-26874

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28

    Frank, T., Reichel, A., Larsen, Olav, Stilp, A., Rosenkilde, Mette, Stamminger, T., Ozawa, T. & Tschammer, N., 12 Dec 2016, In: Cell Communication and Signaling. 14, 16 p., 31.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

    Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119

    Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

    Barington, L., Rummel, P. C., Lückmann, Michael, Pihl, H., Larsen, Olav, Daugvilaite, V., Johnsen, A. H., Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 19 May 2016, In: The Journal of Biological Chemistry. 291, 31, p. 16208-16220

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3

    Milanos, L., Brox, R., Frank, T., Poklukar, G., Palmisano, R., Waibel, R., Einsiedel, J., Dürr, M., Ivanović-Burmazović, I., Larsen, Olav, Hjortø, Gertrud Malene, Rosenkilde, M. M. & Tschammer, N., 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2222-2243 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo

    Janssens, R., Mortier, A., Boff, D., Vanheule, V., Gouwy, M., Franck, C., Larsen, Olav, Rosenkilde, Mette, Damme, J. V., Amaral, F. A., Teixeira, M. M., Struyf, S. & Proost, P., 2016, In: OncoTarget. 7, 38, p. 62439-62459 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. 2015
  31. Published

    Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

    Spiess, Katja, Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjortø, Gertrud Malene, Larsen, Olav, Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N. & Rosenkilde, Mette, Jul 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8427-8432 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2000
  33. Published

    Prevalences of HTLV-1 infection and associated risk determinants in an urban population in Guinea-Bissau, West Africa

    Larsen, Olav, Andersson, S., da Silva, Z., Hedegaard, K., Sandstrom, A., Naucler, A., Dias, F., Melbye, M. & Aaby, P., 1 Oct 2000, In: Journal of Acquired Immune Deficiency Syndromes. 25, 2, p. 157-163

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 1998
  35. Published

    HTLV-1 infection in a population-based cohort of older persons in Guinea-Bissau, West Africa: Risk factors and impact on survival

    Melbye, M., Poulsen, A., Gallo, D., Pedersen, J., Biggar, R., Larsen, Olav, Dias, F. & Aaby, P., 4 May 1998, In: International Journal of Cancer. 76, 3, p. 293-298

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. 1996
  37. Published

    Aggression and personality: Association with amino acids and monoamine metabolites

    Møller, Søren, Mortensen, Erik Lykke, Breum, Leif, Alling, C., Larsen, Olav, Bøge-Rasmussen, T., Jensen, C. & Bennicke, K., Mar 1996, In: Psychological Medicine. 26, 2, p. 323-331 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 138841170