Morten Schak Nielsen

Morten Schak Nielsen

Associate Professor


  1. Published

    Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels

    Alstrøm, J. S., Stroemlund, L. W., Nielsen, Morten Schak & MacAulay, Nanna, Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 519-23 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Isoform-specific phosphorylation-dependent regulation of connexin hemichannels

    Alstrøm, J. S., Hansen, D. B., Nielsen, Morten Schak & MacAulay, Nanna, 15 Nov 2015, In : Journal of Neurophysiology. 114, 5, p. 3014-22 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.

    Angelo, Kamilla, Jespersen, Thomas, Grunnet, M., Nielsen, Morten Schak, Klærke, Dan Arne & Olesen, Søren-Peter, 2002, In : Biophysical Journal. 83, 4, p. 1997-2006 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Increasing gap junctional coupling: a tool for dissecting the role of gap junctions.

    Axelsen, L. N., Haugan, K., Stahlhut, M., Kjølbye, A., Hennan, J. K., Petersen, J. S., Nielsen, Morten Schak & Holstein-Rathlou, N., 2007, In : Journal of Membrane Biology. 216, 1, p. 23-35 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Managing the complexity of communication: regulation of gap junctions by post-translational modification

    Axelsen, L. N., Callø, Kirstine, von Holstein-Rathlou, N. & Nielsen, Morten Schak, Oct 2013, In : Frontiers in Pharmacology. 4, p. 1-18 18 p., 130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).

    Axelsen, L. N., Stahlhut, M., Mohammed, S., Larsen, B. D., Nielsen, Morten Schak, Andersen, S., Jensen, O. N., Hennan, J. K., Kjølbye, A. L. & Holstein-Rathlou, N., 2006, In : Journal of Molecular and Cellular Cardiology. 40, 6, p. 790-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Diet-induced pre-diabetes slows cardiac conductance and promotes arrhythmogenesis

    Axelsen, L. N., Callø, Kirstine, Braunstein, T. H., Riemann, Mads, Hofgaard, J. P., Liang, Bo, Jensen, C. F., Olsen, Kristine Boisen, Bartels, E. D., Baandrup, U., Jespersen, Thomas, Nielsen, L. B., von Holstein-Rathlou, N. & Nielsen, Morten Schak, 14 Jul 2015, In : Cardiovascular Diabetology. 14, 14 p., 87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Intracelllular calcium and ADH stimulated sodium transport in frog skin.

    Bjerregaard, H., Nielsen, Morten Schak & Brodin, B., 1995, In : Pflügers Archiv: European Journal of Physiology. 430, p. R135 (Abstract)

    Research output: Contribution to journalConference abstract in journalResearch

  9. Published

    The angiotensin II type 1 receptor antagonist Losartan binds and activates bradykinin B2 receptor signaling

    Bonde, M. M., Olsen, Kristine Boisen, Erikstrup, N., Speerschneider, T., Lyngsø, C., Haunsø, Stig, Nielsen, Morten Schak, Sheikh, S. P. & Hansen, J. L., 2011, In : Regulatory Peptides. 167, 1, p. 21-25 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.

    Callø, Kirstine, Nielsen, Morten Schak, Grunnet, M., Schmitt, Nicole & Jorgensen, N. K., 2007, In : BBA General Subjects. 1773, 6, p. 764-73 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Genetically modified animals as tools to personalize the study of arrhythmia mechanisms and treatment

    Cerrone, M., Nielsen, Morten Schak & Delmar, M., 2018, ESC CardioMed. Camm, A. J., Lüscher, T. F., Maurer, G. & Serruys, P. W. (eds.). 3 ed. Oxford University Press

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  12. Published

    Connexins and Disease

    Delmar, M., Laird, D. W., Naus, C. C., Nielsen, Morten Schak, Verselis, V. K. & White, T. W., 2018, In : Cold Spring Harbor perspectives in biology. 10, 9, p. 1-18 a029348.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Modulating cardiac conduction during metabolic ischemia with perfusate sodium and calcium in guinea pig hearts

    George, S. A., Hoeker, G., Calhoun, P. J., Entz, M., Raisch, T. B., King, D. R., Khan, M., Baker, C., Gourdie, R. G., Smyth, J. W., Nielsen, Morten Schak & Poelzing, S., 1 Feb 2019, In : American Journal of Physiology: Heart and Circulatory Physiology. 316, 4, p. H849-H861

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Unsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels

    Gnanasambandam, R., Nielsen, Morten Schak, Nicolai, C., Sachs, F., Hofgaard, J. P. & Dreyer, J. K., 2017, In : Frontiers in Neuroinformatics. 11, 16 p., 31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The K+ channels of colonic crypts and their regulation

    Greger, R., Hamm, K., Warth, R., Nielsen, Morten Schak, Weyand, B., Ecke, D., Riedemann, N., Gerlach, U., Busch, A. E., Englert, H. C., Hropot, M., Lang, H. J. & Bleich, M., 1998, In : Korean Journal of Physiology and Pharmacology. 2, 4, p. 403-409 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

    Hansen, D. B., Ye, Z., Callø, Kirstine, Braunstein, T. H., Hofgaard, J. P., Ransom, B. R., Nielsen, Morten Schak & MacAulay, Nanna, 19 Sep 2014, In : The Journal of Biological Chemistry. 289, 38, p. 26058-73 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Distinct permeation profiles of the connexin 30 and 43 hemichannels

    Hansen, D. B., Braunstein, T. H., Nielsen, Morten Schak & MacAulay, Nanna, 17 Apr 2014, In : FEBS letters. 588, 8, p. 1446-57 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The antiarrhythmic peptide analog ZP123 prevents atrial conduction slowing during metabolic stress.

    Haugan, K., Olsen, Kristine Boisen, Hartvig, L., Petersen, J. S., Hennan, J. K., Nielsen, Morten Schak & Holstein-Rathlou, N., 2005, In : Cardiovascular Electrophysiology. 16, 5, p. 537-45 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction.

    Haugan, K., Marcussen, N., Kjølbye, A. L., Nielsen, Morten Schak, Hennan, J. K. & Petersen, J. S., 2006, In : Journal of Cardiovascular Pharmacology. 47, 2, p. 236-42 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Quantification of gap junctional intercellular communication based on digital image analysis

    Hofgaard, J. P., Mollerup, S., Holstein-Rathlou, N. & Nielsen, Morten Schak, 2009, In : American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 297, 2, p. R243-7 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes

    Hofgaard, J. P., Banach, K., Mollerup, S., Jørgensen, H. K., Olesen, Søren-Peter, Holstein-Rathlou, N. & Nielsen, Morten Schak, 2008, In : Pflügers Archiv: European Journal of Physiology. 457, 2, p. 303-13 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Acute intramyocardial lipid accumulation in rats does not slow cardiac conduction per se

    Jensen, C. F., Bartels, E. D., Braunstein, T. H., Nielsen, L. B., Holstein-Rathlou, N., Axelsen, L. N. & Nielsen, Morten Schak, Apr 2019, In : Physiological Reports. 7, 7, 13 p., e14049.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    T-type Ca(2+) channels and Autoregulation of Local Blood Flow

    Jensen, Lars Jørn, Nielsen, Morten Schak, Salomonsson, M. & Sorensen, Charlotte Mehlin, 2017, In : Channels (Austin). 11, 3, p. 183-195 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    RXP-E: a connexin43-binding peptide that prevents action potential propagation block

    Lewandowski, R., Procida, Kristina, Vaidyanathan, R., Coombs, W., Jalife, J., Nielsen, Morten Schak, Taffet, S. M. & Delmar, M., 2008, In : Circulation Research. 103, 5, p. 519-26 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Astrocytic connexin hemichannels are regulated by PKC phosphorylation in an isoform-specific manner

    MacAulay, Nanna, Alstrom, J. S., Hansen, D. B. & Nielsen, Morten Schak, 2017, In : Glia. 65, S1, p. E64-E64 S17-01.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  26. Published

    Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions

    Mollerup, S., Hofgaard, J. P., Braunstein, T. H., Kjenseth, A., Leithe, E., Rivedal, E., von Holstein-Rathlou, N. & Nielsen, Morten Schak, 21 Sep 2011, In : Cell Communication & Adhesion (Print Edition). 18, 4, p. 57-65 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Sphingosine-1-Phosphate reduces ischemia/reperfusion injury by phosphorylating the gap junction protein Connexin43

    Morel, S., Christoffersen, Christina, Axelsen, L. N., Montecucco, F., Rochemont, V., Frias, M. A., Mach, F., James, R. W., Naus, C. C., Chanson, M., Lampe, P. D., Nielsen, Morten Schak, Nielsen, L. B. & Kwak, B. R., 13 Jan 2016, In : Cardiovascular Research. 109, p. 385-396 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics

    Nielsen, B. S., Hansen, D. B., Ransom, B. R., Nielsen, Morten Schak & MacAulay, Nanna, Sep 2017, In : Neurochemical Research. 42, 9, p. 2537–2550 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Pannexin 1 activation and inhibition is permeant-selective

    Nielsen, B. S., Toft-Bertelsen, Trine Lisberg, Lolansen, Sara Diana, Anderson, C. L., Nielsen, Morten Schak, Thompson, R. J. & MacAulay, Nanna, 2020, In : The Journal of Physiology. 598, 2, p. 361-379 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Structural determinants underlying permeant discrimination of the Cx43 hemichannel

    Nielsen, B. S., Zonta, F., Farkas, T., Litman, Thomas, Nielsen, Morten Schak & MacAulay, Nanna, 2019, In : Journal of Biological Chemistry. 294, 45, p. 16789-16803 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Permeant-specific gating of connexin 30 hemichannels

    Nielsen, B. S., Alstrom, J. S., Nicholson, B., Nielsen, Morten Schak & MacAulay, Nanna, 2017, In : Journal of Biological Chemistry. 292, 49, p. 19999-20009

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    The basolateral Ca2+-dependent K+ channel in rat colonic crypt cells

    Nielsen, Morten Schak, Warth, R., Bleich, M., Weyand, B. & Greger, R., 1998, In : Pflügers Archiv: European Journal of Physiology. 435, p. 267-272

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Regulation of cellular and paracellular ion fluxes in frog skin glands.

    Nielsen, Morten Schak & Nielsen, R., 1993, Glasgow: XXXII Congress of the International Uni3. 21 p.

    Research output: Book/ReportBookResearch

  34. Published

    K+ is actively secreted in the frog skin gland.

    Nielsen, Morten Schak & Nielsen, R., 1994, In : Acta Physiologica (Print Edition). 151, p. 26A

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Gap Junctions

    Nielsen, Morten Schak, Axelsen, L. N., Sorgen, P., Verma, V., Mario, D. & von Holstein-Rathlou, N., 2012, In : Comprehensive Physiology. 2, p. 1981-2035

    Research output: Contribution to journalReviewResearchpeer-review

  36. Published

    Effect of carbachol and prostaglandin E2 on chloride secretion and signal transduction in the exocrine glands of frog skin (Rana esculenta)

    Nielsen, Morten Schak & Nielsen, R., 1999, In : Pflügers Archiv: European Journal of Physiology. 438, p. 732-740

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Myocyte-fibroblast interactions--risky connections

    Nielsen, Morten Schak, 2009, In : Heart Rhythm. 6, 11, p. 1650-1 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Lateralized gap junctions in pulmonary hypertension - lost but not alone

    Nielsen, Morten Schak, 2012, In : Heart Rhythm. 9, 7, p. 1141-1142 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Probenecid inhibits α-adrenergic receptor-mediated vasoconstriction in the human leg vasculature

    Nyberg, M. P., Piil, Peter, Kiehn, O. T., Maagaard, C., Jørgensen, T. S., Egelund, J., Isakson, B. E., Nielsen, Morten Schak, Gliemann, Lasse & Hellsten, Ylva, 2018, In : Hypertension. 71, 1, p. 151-159 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Estimation of the effective intercellular diffusion coefficient in cell monolayers coupled by gap junctions

    Olesen, N. E., Hofgaard, J. P., von Holstein-Rathlou, N., Nielsen, Morten Schak & Jacobsen, Jens Christian Brings, 2012, In : European Journal of Pharmaceutical Sciences. 46, 4, p. 222-32 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Angiotensin II does not acutely regulate conduction velocity in rat atrial tissue

    Olsen, Kristine Boisen, Braunstein, T. H., Sorensen, Charlotte Mehlin, Axelsen, L. N., Holstein-Rathlou, N. & Nielsen, Morten Schak, 6 Jul 2011, In : Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. 71, 6, p. 492 499 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Myocardial impulse propagation is impaired in right ventricular tissue of Zucker Diabetic Fatty (ZDF) rats

    Olsen, Kristine Boisen, Axelsen, L. N., Braunstein, T. H., Sorensen, Charlotte Mehlin, Andersen, C. B., Ploug, Thorkil, von Holstein-Rathlou, N. & Nielsen, Morten Schak, 2013, In : Cardiovascular Diabetology. 12, p. 19 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Phosphorylation of connexin43 on serine 306 regulates electrical coupling

    Procida, Kristina, Jørgensen, L., Schmitt, Nicole, Delmar, M., Taffet, S. M., Holstein-Rathlou, N., Nielsen, Morten Schak & Braunstein, T. H., 2009, In : Heart Rhythm. 6, 11, p. 1632-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Sympathetic vasoconstriction takes an unexpected pannexin detour

    Nielsen, Morten Schak, 17 Feb 2015, In : Science signaling. 8, 364, p. 1-2 2 p., fs4.

    Research output: Contribution to journalComment/debateResearchpeer-review

  45. Published

    Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium

    Skibsbye, L., Wang, X., Axelsen, L. N., Bomholtz, S. H., Nielsen, Morten Schak, Grunnet, M., Bentzen, Bo Hjorth & Jespersen, Thomas, Aug 2015, In : Journal of Cardiovascular Pharmacology. 66, 2, p. 165-176 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles (American Journal of Physiology - Regulatory Integrative and Comparative Physiology (2008) 295, (R840-R847) DOI:10.1152/ajpregu.00491.2007)

    Sorensen, Charlotte Mehlin, Salomonsson, M., Braunstein, T. H., Nielsen, Morten Schak & Holstein-Rathlou, N. H., 1 Jan 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 1

    Research output: Contribution to journalComment/debateResearchpeer-review

  47. Published

    Protein⁻Protein Interactions with Connexin 43: Regulation and Function

    Sorgen, P. L., Trease, A. J., Spagnol, G., Delmar, M. & Nielsen, Morten Schak, 10 May 2018, In : International Journal of Molecular Sciences. 19, 5, 21 p., 1428.

    Research output: Contribution to journalReviewResearchpeer-review

  48. Published

    Gap junctions-guards of excitability

    Stroemlund, L. W., Jensen, C. F., Qvortrup, Klaus, Delmar, M. & Nielsen, Morten Schak, 1 Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 508-12 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles.

    Sorensen, Charlotte Mehlin, Salomonsson, M., Braunstein, T. H., Nielsen, Morten Schak & Holstein-Rathlou, N., 2008, In : American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 295, 3, p. R840-7

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Maxi K+ channels co-localised with CFTR in the apical membrane of an exocrine gland acinus: possible involvement in secretion

    Sørensen, J. B., Nielsen, Morten Schak, Gudme, C. N., Larsen, Erik Hviid & Nielsen, R., 2001, In : Pflügers Archiv: European Journal of Physiology. 442, p. 1-11

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Uremia increases QRS duration after β-adrenergic stimulation in mice

    Thomsen, Morten Bækgaard, Nielsen, Morten Schak, Aarup, A., Bisgaard, Line Stattau & Pedersen, Tanja Xenia, 1 Jul 2018, In : Physiological Reports. 6, 13, 13 p., e13720.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome

    Thorsen, K., Dam, V. S., Kjaer-Sorensen, K., Pedersen, L. N., Skeberdis, V. A., Jurevicius, J., Treinys, R., Petersen, I. M. B. S., Nielsen, Morten Schak, Oxvig, C., Morth, J. P., Matchkov, V. V., Aalkjær, Christian, Bundgård, Henning & Jensen, H. K., 22 Nov 2017, In : Nature Communications. 8, 10 p., 1696.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Synopsis of the International Gap Junction Conference in Elsinore, Denmark August 5-9, 2007.

    Willecke, K. & Nielsen, Morten Schak, 2008, In : Cell Communication & Adhesion (Print Edition). 14, 6, p. 251-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs.

    Xing, D., Kjølbye, A. L., Nielsen, Morten Schak, Petersen, J. S., Harlow, K. W., Martins, J. B. & Holstein-Rathlou, N., 2003, In : Cardiovascular Electrophysiology. 14, 5, p. 510-20 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 6471