Michael Jonathan Davies

Michael Jonathan Davies

Professor

ORCID: 0000-0002-5196-6919

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  1. Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins

    Zeng, J. & Davies, Michael Jonathan, Aug 2005, In : Chemical Research in Toxicology. 18, 8, p. 1232-41 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Exploring oxidative modifications of tyrosine: An update on mechanisms of formation, advances in analysis and biological consequences

    Houée-Lévin, C., Bobrowski, K., Horakova, L., Karademir, B., Schöneich, C., Davies, Michael Jonathan & Spickett, C. M., Apr 2015, In : Free Radical Research. 49, 4, p. 347-73 27 p.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Exposure of aconitase to smoking-related oxidants results in iron loss and increased iron response protein-1 activity: potential mechanisms for iron accumulation in human arterial cells

    Talib, J. & Davies, Michael Jonathan, 2016, In : Journal of Biological Inorganic Chemistry. 21, 3, p. 305-317 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function: [Meeting Abstract]

    Degendorfer, G., Lorentzen, Lasse Gøbel, Chuang, Christine, Mariotti, M., Hammer, A., Hoefler, G., Haegglund, P., Malle, E., Wise, S. & Davies, Michael Jonathan, 2018, In : Free Radical Biology and Medicine. 120, S1, p. S102-S103 P-192 .

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  5. Published

    Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function

    Degendorfer, G., Chuang, Christine, Mariotti, M., Hammer, A., Hoefler, G., Hägglund, Per Mårten, Malle, E., Wise, S. G. & Davies, Michael Jonathan, 1 Feb 2018, In : Free Radical Biology & Medicine. 115, S1, p. 202-214 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    FIBROSIS IS NOT JUST FIBROSIS - TGF-B AND PDGF INDUCE DIFFERENT EXTRACELLULAR MATRIX PROFILE: A MODEL OF DERMAL FIBROBLASTS WHICH MIMICS SYSTEMIC SCLEROSIS POTENTIAL FOR EVALUATION OF ANTI-FIBROTIC COMPOUNDS WITH TRANSLATIONAL BIOMARKERS [Meeting Abstract}

    Juhl, P., Bomdesen, S., Bay-Jensen, A., Karsdal, M., Davies, Michael Jonathan & Siebuhr, A. S., 2019, In : Annals of the Rheumatic Diseases. 78, S2, p. 448-449 THU0335.

    Research output: Contribution to journal › Conference abstract in journal › Research

  7. Published

    Formation and characterization of crosslinks, including Tyr-Trp species, on one electron oxidation of free Tyr and Trp residues by carbonate radical anion

    Figueroa, J. D., Zárate, A. M., Fuentes Lemus, Eduardo, Davies, Michael Jonathan & López-Alarcón, C., 2020, In : RSC Advances. 10, 43, p. 25786-25800 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Formation and detection of oxidant-generated tryptophan dimers in peptides and proteins

    Carroll, L., Pattison, D. I., Davies, J. B., Anderson, R. F., Lopez-Alarcon, C. & Davies, Michael Jonathan, Dec 2017, In : Free Radical Biology & Medicine. 113, p. 132-142 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Formation of hydroxyl radicals in the human lens is related to the severity of nuclear cataract

    Garner, B., Davies, Michael Jonathan & Truscott, R. J., Jan 2000, In : Experimental Eye Research. 70, 1, p. 81-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Formation of long-lived radicals on proteins by radical transfer from heme enzymes--a common process?

    Ostdal, H., Andersen, H. J. & Davies, Michael Jonathan, 1 Feb 1999, In : Archives of Biochemistry and Biophysics. 362, 1, p. 105-12 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Fragmentation of extracellular matrix by hypochlorous acid

    Woods, A. A. & Davies, Michael Jonathan, 15 Nov 2003, In : Biochemical Journal. 376, Pt 1, p. 219-27 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Free Radical Research origins

    Davies, Michael Jonathan, Jan 2012, In : Free Radical Research. 46, 1, p. 1

    Research output: Contribution to journal › Journal article › Research

  13. Published

    Generation and propagation of radical reactions on proteins

    Hawkins, C. L. & Davies, Michael Jonathan, 2 Apr 2001, In : B B A - Reviews on Cancer. 1504, 2-3, p. 196-219 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Generation of Aggregates of α-Lactalbumin by UV-B Light Exposure

    Zhao, Z., Engholm-Keller, Kasper, Poojary, Mahesha Manjunatha, Boelt, S. G., Rogowska-Wrzesinska, A., Skibsted, Leif Horsfelt, Davies, Michael Jonathan & Lund, Marianne N., 2020, In : Journal of Agricultural and Food Chemistry. 68, 24, p. 6701-6714 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction

    Galougahi, K. K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N. A. S., Davies, Michael Jonathan, Hawkins, Clare Louise, Rasmussen, H. H. & Figtree, G. A., 2014, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 3, 2, p. e000731

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes. Formation of modified and oxidized particles

    Knott, H. M., Brown, B. E., Davies, Michael Jonathan & Dean, R. T., Sep 2003, In : European Journal of Biochemistry. 270, 17, p. 3572-82 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages

    Brown, B. E., Rashid, I., van Reyk, D. M. & Davies, Michael Jonathan, Mar 2007, In : F E B S Journal. 274, 6, p. 1530-41 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells

    Brown, B. E., Dean, R. T. & Davies, Michael Jonathan, Feb 2005, In : Diabetologia. 48, 2, p. 361-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Glycosaminoglycans are fragmented by hydroxyl, carbonate, and nitrogen dioxide radicals in a site-selective manner: implications for peroxynitrite-mediated damage at sites of inflammation

    Kennett, E. C. & Davies, Michael Jonathan, 15 Aug 2009, In : Free Radical Biology & Medicine. 47, 4, p. 389-400 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Guanine-specific DNA damage induced by gamma-irradiated histone

    Furukawa, A., Hiraku, Y., Oikawa, S., Luxford, C., Davies, Michael Jonathan & Kawanishi, S., 15 Jun 2005, In : Biochemical Journal. 388, Pt 3, p. 813-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Heparan sulfate degradation via reductive homolysis of its N-chloro derivatives

    Rees, M. D. & Davies, Michael Jonathan, 8 Mar 2006, In : Journal of the American Chemical Society. 128, 9, p. 3085-97 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction

    Nedoboy, P. E., Morgan, P. E., Mocatta, T. J., Richards, A. M., Winterbourn, C. C. & Davies, Michael Jonathan, Oct 2014, In : Free Radical Research. 48, 10, p. 1256-66 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

    Morgan, P. E., Pattison, D. I., Talib, J., Summers, F. A., Harmer, J. A., Celermajer, D. S., Hawkins, Clare Louise & Davies, Michael Jonathan, 1 Nov 2011, In : Free Radical Biology & Medicine. 51, 9, p. 1815-22 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine

    Talib, J., Pattison, D. I., Harmer, J. A., Celermajer, D. S. & Davies, Michael Jonathan, 1 Jul 2012, In : Free Radical Biology & Medicine. 53, 1, p. 20-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA

    Luxford, C., Morin, B., Dean, R. T. & Davies, Michael Jonathan, 15 Nov 1999, In : Biochemical Journal. 344 Pt 1, p. 125-34 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Hypobromous acid and bromamine production by neutrophils and modulation by superoxide

    Chapman, A. L. P., Skaff, O., Senthilmohan, R., Kettle, A. J. & Davies, Michael Jonathan, 1 Feb 2009, In : Biochemical Journal. 417, 3, p. 773-81 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates

    Rees, M. D., Hawkins, Clare Louise & Davies, Michael Jonathan, 1 Jul 2004, In : Biochemical Journal. 381, Pt 1, p. 175-84 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis

    Hawkins, C. L., Brown, B. E. & Davies, Michael Jonathan, 15 Nov 2001, In : Archives of Biochemistry and Biophysics. 395, 2, p. 137-45 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Hypochlorite-induced damage to DNA, RNA, and polynucleotides: formation of chloramines and nitrogen-centered radicals

    Hawkins, Clare Louise & Davies, Michael Jonathan, Jan 2002, In : Chemical Research in Toxicology. 15, 1, p. 83-92 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Hypochlorite-induced damage to nucleosides: formation of chloramines and nitrogen-centered radicals

    Hawkins, C. L. & Davies, Michael Jonathan, Aug 2001, In : Chemical Research in Toxicology. 14, 8, p. 1071-81 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Hypochlorite-induced damage to proteins: formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation

    Hawkins, C. L. & Davies, Michael Jonathan, 15 Jun 1998, In : Biochemical Journal. 332 ( Pt 3), p. 617-25 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Hypochlorite-induced damage to red blood cells: evidence for the formation of nitrogen-centred radicals

    Hawkins, C. L. & Davies, Michael Jonathan, 2000, In : Redox Report (Online). 5, 1, p. 57-9 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Hypochlorite-induced oxidation of amino acids, peptides and proteins

    Hawkins, C. L., Pattison, D. I. & Davies, Michael Jonathan, Dec 2003, In : Amino Acids. 25, 3-4, p. 259-74 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation

    Hawkins, C. L. & Davies, Michael Jonathan, 1 Jun 1999, In : Biochemical Journal. 340 ( Pt 2), p. 539-48 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Hypochlorite-induced oxidation of thiols: formation of thiyl radicals and the role of sulfenyl chlorides as intermediates

    Davies, Michael Jonathan & Hawkins, C. L., Dec 2000, In : Free Radical Research. 33, 6, p. 719-29 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Hypochlorite-mediated fragmentation of hyaluronan, chondroitin sulfates, and related N-acetyl glycosamines: evidence for chloramide intermediates, free radical transfer reactions, and site-specific fragmentation

    Rees, M. D., Hawkins, Clare Louise & Davies, Michael Jonathan, 12 Nov 2003, In : Journal of the American Chemical Society. 125, 45, p. 13719-33 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin

    Szuchman-Sapir, A. J., Pattison, D. I., Ellis, N. A., Hawkins, Clare Louise, Davies, Michael Jonathan & Witting, P. K., 15 Sep 2008, In : Free Radical Biology & Medicine. 45, 6, p. 789-98 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Hypochlorous acid-mediated oxidation of lipid components and antioxidants present in low-density lipoproteins: absolute rate constants, product analysis, and computational modeling

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael Jonathan, Apr 2003, In : Chemical Research in Toxicology. 16, 4, p. 439-49 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael Jonathan, 28 Aug 2007, In : Biochemistry. 46, 34, p. 9853-64 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

    Cai, H., Chuang, Christine, Vanichkitrungruang, S., Hawkins, Clare Louise & Davies, Michael Jonathan, 2019, In : Free Radical Biology and Medicine. 134, p. 526-536

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

    Lloyd, M. M., van Reyk, D. M., Davies, Michael Jonathan & Hawkins, Clare Louise, 1 Sep 2008, In : Biochemical Journal. 414, 2, p. 271-80 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance

    Skaff, O., Pattison, D. I. & Davies, Michael Jonathan, 15 Aug 2009, In : Biochemical Journal. 422, 1, p. 111-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Identification and characterization of protein cross-links induced by oxidative reactions

    Hägglund, Per Mårten, Mariotti, M. & Davies, Michael Jonathan, 2018, In : Expert Review of Proteomics. 15, 8, p. 665-681

    Research output: Contribution to journal › Review › Research › peer-review

  44. Published

    Identification and quantification of sites of nitration and oxidation in the key matrix protein laminin and the structural consequences of these modifications

    Lorentzen, Lasse Gøbel, Chuang, Christine, Rogowska-Wrzesinska, A. & Davies, Michael Jonathan, 2019, In : Redox Biology. 24, UNSP 101226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines

    Summers, F. A., Morgan, P. E., Davies, Michael Jonathan & Hawkins, Clare Louise, Sep 2008, In : Chemical Research in Toxicology. 21, 9, p. 1832-40 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Impact of myeloperoxidase-derived oxidants on vascular smooth muscle cell damage and death in atherosclerosis {Meeting Abstract]

    Flouda, Konstantina, Davies, Michael Jonathan & Hawkins, C., 2019, In : Free Radical Biology and Medicine. 139, S1, p. S23-S24 64.

    Research output: Contribution to journal › Conference abstract in journal › Research

  47. Published

    Inactivation of cellular caspases by peptide-derived tryptophan and tyrosine peroxides

    Hampton, M. B., Morgan, P. E. & Davies, Michael Jonathan, 11 Sep 2002, In : FEBS letters. 527, 1-3, p. 289-92 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Inactivation of cellular enzymes by carbonyls and protein-bound glycation/glycoxidation products

    Morgan, P. E., Dean, R. T. & Davies, Michael Jonathan, 15 Jul 2002, In : Archives of Biochemistry and Biophysics. 403, 2, p. 259-69 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Inactivation of protease inhibitors and lysozyme by hypochlorous acid: role of side-chain oxidation and protein unfolding in loss of biological function

    Hawkins, Clare Louise & Davies, Michael Jonathan, Oct 2005, In : Chemical Research in Toxicology. 18, 10, p. 1600-10 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

    Barrett, T. J., Pattison, D. I., Leonard, S. E., Carroll, K. S., Davies, Michael Jonathan & Hawkins, Clare Louise, 15 Mar 2012, In : Free Radical Biology & Medicine. 52, 6, p. 1075-85 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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