Michael J. Davies

Michael J. Davies

Professor

ORCID: 0000-0002-5196-6919

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  1. High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

    Morgan, P. E., Pattison, D. I., Talib, J., Summers, F. A., Harmer, J. A., Celermajer, D. S., Hawkins, Clare Louise & Davies, Michael J., 1 Nov 2011, In: Free Radical Biology & Medicine. 51, 9, p. 1815-22 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine

    Talib, J., Pattison, D. I., Harmer, J. A., Celermajer, D. S. & Davies, Michael J., 1 Jul 2012, In: Free Radical Biology & Medicine. 53, 1, p. 20-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA

    Luxford, C., Morin, B., Dean, R. T. & Davies, Michael J., 15 Nov 1999, In: Biochemical Journal. 344 Pt 1, p. 125-34 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Hypobromous acid and bromamine production by neutrophils and modulation by superoxide

    Chapman, A. L. P., Skaff, O., Senthilmohan, R., Kettle, A. J. & Davies, Michael J., 1 Feb 2009, In: Biochemical Journal. 417, 3, p. 773-81 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates

    Rees, M. D., Hawkins, Clare Louise & Davies, Michael J., 1 Jul 2004, In: Biochemical Journal. 381, Pt 1, p. 175-84 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis

    Hawkins, C. L., Brown, B. E. & Davies, Michael J., 15 Nov 2001, In: Archives of Biochemistry and Biophysics. 395, 2, p. 137-45 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Hypochlorite-induced damage to DNA, RNA, and polynucleotides: formation of chloramines and nitrogen-centered radicals

    Hawkins, Clare Louise & Davies, Michael J., Jan 2002, In: Chemical Research in Toxicology. 15, 1, p. 83-92 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Hypochlorite-induced damage to nucleosides: formation of chloramines and nitrogen-centered radicals

    Hawkins, C. L. & Davies, Michael J., Aug 2001, In: Chemical Research in Toxicology. 14, 8, p. 1071-81 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Hypochlorite-induced damage to proteins: formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation

    Hawkins, C. L. & Davies, Michael J., 15 Jun 1998, In: Biochemical Journal. 332 ( Pt 3), p. 617-25 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Hypochlorite-induced damage to red blood cells: evidence for the formation of nitrogen-centred radicals

    Hawkins, C. L. & Davies, Michael J., 2000, In: Redox Report (Online). 5, 1, p. 57-9 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Hypochlorite-induced oxidation of amino acids, peptides and proteins

    Hawkins, C. L., Pattison, D. I. & Davies, Michael J., Dec 2003, In: Amino Acids. 25, 3-4, p. 259-74 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation

    Hawkins, C. L. & Davies, Michael J., 1 Jun 1999, In: Biochemical Journal. 340 ( Pt 2), p. 539-48 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Hypochlorite-induced oxidation of thiols: formation of thiyl radicals and the role of sulfenyl chlorides as intermediates

    Davies, Michael J. & Hawkins, C. L., Dec 2000, In: Free Radical Research. 33, 6, p. 719-29 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Hypochlorite-mediated fragmentation of hyaluronan, chondroitin sulfates, and related N-acetyl glycosamines: evidence for chloramide intermediates, free radical transfer reactions, and site-specific fragmentation

    Rees, M. D., Hawkins, Clare Louise & Davies, Michael J., 12 Nov 2003, In: Journal of the American Chemical Society. 125, 45, p. 13719-33 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity

    Wang, Y., Hammer, A., Hoefler, G., Malle, E., Hawkins, Clare Louise, Chuang, Christine & Davies, Michael J., 2023, In: Antioxidants. 12, 2, 25 p., 420.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin

    Szuchman-Sapir, A. J., Pattison, D. I., Ellis, N. A., Hawkins, Clare Louise, Davies, Michael J. & Witting, P. K., 15 Sep 2008, In: Free Radical Biology & Medicine. 45, 6, p. 789-98 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Hypochlorous acid-mediated oxidation of lipid components and antioxidants present in low-density lipoproteins: absolute rate constants, product analysis, and computational modeling

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., Apr 2003, In: Chemical Research in Toxicology. 16, 4, p. 439-49 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., 28 Aug 2007, In: Biochemistry. 46, 34, p. 9853-64 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

    Cai, H., Chuang, Christine, Vanichkitrungruang, S., Hawkins, Clare Louise & Davies, Michael J., 2019, In: Free Radical Biology and Medicine. 134, p. 526-536

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

    Lloyd, M. M., van Reyk, D. M., Davies, Michael J. & Hawkins, Clare Louise, 1 Sep 2008, In: Biochemical Journal. 414, 2, p. 271-80 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance

    Skaff, O., Pattison, D. I. & Davies, Michael J., 15 Aug 2009, In: Biochemical Journal. 422, 1, p. 111-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Hypoxia of human endothelial artery wall cells affects arterial extracellular matrix remodelling and contributes to atherosclerosis development

    Huang, S., Chuang, Christine & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 563 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  23. Published

    Identification and characterization of protein cross-links induced by oxidative reactions

    Hägglund, Per Mårten, Mariotti, M. & Davies, Michael J., 2018, In: Expert Review of Proteomics. 15, 8, p. 665-681

    Research output: Contribution to journal › Review › Research › peer-review

  24. Published

    Identification and quantification of protein nitration sites in human coronary artery smooth muscle cells in the absence and presence of peroxynitrous acid/peroxynitrite

    Xu, Shuqi, Chuang, Christine, Hawkins, Clare Louise, Hägglund, Per Mårten & Davies, Michael J., 2023, In: Redox Biology. 64, 13 p., 102799.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Identification and quantification of sites of nitration and oxidation in the key matrix protein laminin and the structural consequences of these modifications

    Lorentzen, Lasse Gøbel, Chuang, Christine, Rogowska-Wrzesinska, A. & Davies, Michael J., 2019, In: Redox Biology. 24, UNSP 101226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids

    Trammell, Sam, Gamon, Luke Francis, Gotfryd, K., Michler, Katja Thorøe, Alrehaili, B. D., Rix, I., Knop, Filip Krag, Gourdon, Pontus Emanuel, Lee, Y. K., Davies, Michael J., Gillum, M. P. & Grevengoed, Trisha Jean, 2023, In: Journal of Lipid Research. 64, 9, 9 p., 100361.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Identification of galectin-1 and other cellular targets of alpha,beta-unsaturated carbonyl compounds, including dimethylfumarate, by use of click-chemistry probes

    Sauerland, Max Benjamin, Helm, C., Lorentzen, Lasse Gøbel, Manandhar, Asmita, Ulven, Trond, Gamon, Luke Francis & Davies, Michael J., 2023, In: Redox Biology. 59, 15 p., 102560.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines

    Summers, F. A., Morgan, P. E., Davies, Michael J. & Hawkins, Clare Louise, Sep 2008, In: Chemical Research in Toxicology. 21, 9, p. 1832-40 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Impact of myeloperoxidase-derived oxidants on vascular smooth muscle cell damage and death in atherosclerosis {Meeting Abstract]

    Flouda, K., Davies, Michael J. & Hawkins, C., 2019, In: Free Radical Biology and Medicine. 139, S1, p. S23-S24 64.

    Research output: Contribution to journal › Conference abstract in journal › Research

  30. Published

    Implications of differential peroxyl radical-induced inactivation of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase for the pentose phosphate pathway

    Reyes, J. S., Fuentes Lemus, Eduardo, Figueroa, J. D., Rojas, J., Fierro, A., Arenas, F., Hägglund, Per Mårten, Davies, Michael J. & López-Alarcón, C., 2022, In: Scientific Reports. 12, 1, 19 p., 21191.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    In memoriam: Emeritus Professor Robin L. Willson

    Davies, Michael J., Davies, K. J. A., Halliwell, B., Jackson, M. J., Mann, G. E., Poli, G., Radi, R., Riley, P. A., Sies, H., Ward, J. F., Wardman, P. & Willson, J., 2022, In: Free Radical Research. 56, 7-8, p. 572-576 5 p.

    Research output: Contribution to journal › Journal article › Research

  32. Published

    Inactivation of cellular caspases by peptide-derived tryptophan and tyrosine peroxides

    Hampton, M. B., Morgan, P. E. & Davies, Michael J., 11 Sep 2002, In: FEBS Letters. 527, 1-3, p. 289-92 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Inactivation of cellular enzymes by carbonyls and protein-bound glycation/glycoxidation products

    Morgan, P. E., Dean, R. T. & Davies, Michael J., 15 Jul 2002, In: Archives of Biochemistry and Biophysics. 403, 2, p. 259-69 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Inactivation of protease inhibitors and lysozyme by hypochlorous acid: role of side-chain oxidation and protein unfolding in loss of biological function

    Hawkins, Clare Louise & Davies, Michael J., Oct 2005, In: Chemical Research in Toxicology. 18, 10, p. 1600-10 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

    Barrett, T. J., Pattison, D. I., Leonard, S. E., Carroll, K. S., Davies, Michael J. & Hawkins, Clare Louise, 15 Mar 2012, In: Free Radical Biology & Medicine. 52, 6, p. 1075-85 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus

    Morgan, P. E., Sturgess, A. D. & Davies, Michael J., Jul 2005, In: Arthritis & Rheumatism. 52, 7, p. 2069-79 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Increasing capacity to deliver diabetes self-management education: Results of the DESMOND lay educator non-randomized controlled equivalence trial

    Carey, M. E., Mandalia, P. K., Daly, H., Gray, L. J., Hale, R., Martin Stacey, L., Taub, N., Skinner, Timothy, Stone, M., Heller, S., Khunti, K. & Davies, Michael J., 1 Jan 2014, In: Diabetic Medicine. 31, 11, p. 1431-1438 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Induction of DNA damage by oxidised amino acids and proteins

    Luxford, C., Dean, R. T. & Davies, Michael J., 2002, In: Biogerontology. 3, 1-2, p. 95-102 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Influence of O-2 on riboflavin-mediated photo-oxidation of lysozyme: [Meeting Abstract]

    Silva, E., Tirapegui, C., Fuentes-Lemus, E., Barrias, P., Aspee, A., Lorentzen, Lasse Gøbel, Caroll, L., Leinisch, F., Davies, Michael J. & Lopez-Alarcon, C., 2018, In: Free Radical Biology and Medicine. 120, S1, p. S58-S59 P-46.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  40. Published

    Influence of plasma halide, pseudohalide and nitrite ions on myeloperoxidase-mediated protein and extracellular matrix damage

    Xu, Shuqi, Chuang, Christine, Malle, E., Gamon, Luke Francis, Hawkins, Clare Louise & Davies, Michael J., 2022, In: Free Radical Biology and Medicine. 188, p. 162-174

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone

    Shu, N., Cheng, Q., Arner, E. S. J. & Davies, Michael J., 2020, In: Redox Biology. 28, 9 p., 101335 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Inhibition of cathepsins and related proteases by amino acid, peptide, and protein hydroperoxides

    Headlam, H. A., Gracanin, M., Rodgers, K. J. & Davies, Michael J., 1 May 2006, In: Free Radical Biology & Medicine. 40, 9, p. 1539-48 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack

    Morgan, P. E., Dean, R. T. & Davies, Michael J., Apr 2002, In: European Journal of Biochemistry. 269, 7, p. 1916-25 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: a potential contributory factor in diabetes-associated atherosclerosis

    Moheimani, F., Kim, C. H. J., Rahmanto, A. S., van Reyk, D. M. & Davies, Michael J., Jul 2012, In: Atherosclerosis. 223, 1, p. 144-51 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

    Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K., Fu, S., Bottle, S. E., Hawkins, Clare Louise & Davies, Michael J., May 2014, In: Free Radical Biology & Medicine. 70, p. 96-105 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides

    Rees, M. D., Bottle, S. E., Fairfull-Smith, K. E., Malle, E., Whitelock, J. M. & Davies, Michael J., 1 Jul 2009, In: Biochemical Journal. 421, 1, p. 79-86 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Inhibition of protein tyrosine phosphatases by amino acid, peptide, and protein hydroperoxides: potential modulation of cell signaling by protein oxidation products

    Gracanin, M. & Davies, Michael J., 15 May 2007, In: Free Radical Biology & Medicine. 42, 10, p. 1543-51 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Interaction kinetics of selenium -containing compounds with oxidants

    Carroll, L., Gardiner, K., Ignasiak, M., Holmehave, J., Shimodaira, S., Breitenbach, T., Iwaoka, M., Ogilby, P. R., Pattison, David & Davies, Michael J., 2020, In: Free Radical Biology and Medicine. 155, p. 58-68

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Iodide anions show protective and damaging effects in oxidation of amino acids, peptides and proteins: [Meeting Abstract]

    Ignasiak-Kciuk, M., Shashikadze, B., Frackowiak, K., Gamon, Luke Francis, Davies, Michael J. & Marciniak, B., 2019, In: Free Radical Biology and Medicine. 139, S1, p. S30-S30 89.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  50. Published

    Iodide modulates myeloperoxidase-derived oxidative damage to extracellular matrix proteins: [Meeting Abstract]

    Gamon, Luke Francis, Ignasiak, M. T., Dieterich, S. D., Sauerland, Max Benjamin, Goll, S. T. & Davies, Michael J., 1 Aug 2019, In: Free Radical Biology and Medicine. 139, S1, p. S8-S8 2.

    Research output: Contribution to journal › Conference abstract in journal › Research

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