Lykke Sylow

Lykke Sylow

Associate Professor - Promotion Programme

ORCID: 0000-0003-0905-5932

Publication year:
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1 - 50 out of 71Page size: 50
  1. 2011
  2. Published

    Current understanding of increased insulin sensitivity after exercise - emerging candidates

    Maarbjerg, S. J., Sylow, Lykke & Richter, Erik A., 2011, In: Acta Physiologica. 202, 3, p. 323-335 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

    Chiu, T. T., Jensen, Thomas Elbenhardt, Sylow, Lykke, Richter, Erik A. & Klip, A., 2011, In: Cellular Signalling. 23, 10, p. 1546-1554 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  4. 2012
  5. Published

    Overexpression of monocarboxylate transporter-1 (Slc16a1) in mouse pancreatic ß-cells leads to relative hyperinsulinism during exercise

    Pullen, T. J., Sylow, Lykke, Sun, G., Halestrap, A. P., Richter, Erik A. & Rutter, G. A., 2012, In: Diabetes. 61, 7, p. 1719-1725 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2013
  7. Published

    Body composition and metabolic characterization.

    Kristensen, Jonas Møller, Kiens, Bente, Sylow, Lykke, Maarbjerg, S. J., Alsted, T. J., Frosig, C., Jeppesen, J., Jensen, T. E., Schjerling, Peter, Treebak, Jonas Thue, Wojtaszewski, Jørgen F P, Richter, Erik A. & Pehmoller, C., 2013

    Research output: Other contribution › Research

  8. Published

    Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

    Beck Jørgensen, S., O'Neill, H. M., Sylow, Lykke, Honeyman, J., Hewitt, K. A., Palanivel, R., Fullerton, M. D., Öberg, L., Balendran, A., Galic, S., van der Poel, C., Trounce, I. A., Lynch, G. S., Schertzer, J. D. & Steinberg, G. R., 2013, In: Diabetes. 62, 1, p. 56-64 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Involvement of Rac1 and the actin cytoskeleton in insulin- and contraction-stimulated intracellular signaling and glucose uptake in mature skeletal muscle

    Sylow, Lykke, 2013, Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  10. Published

    LKB1 regulates lipid oxidation during exercise independently of AMPK

    Jeppesen, J. F., Maarbjerg, S. J., Jordy, A. B., Fritzen, Andreas Mæchel, Pehmøller, C., Sylow, Lykke, Serup, A. K. L., Jessen, N., Thorsen, K., Prats Gavalda, Clara, Qvortrup, Klaus, Dyck, J. R. B., Hunter, R. W., Sakamoto, Kei, Thomson, D. M., Schjerling, Peter, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2013, In: Diabetes. 62, 5, p. 1490-1499 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

    Sylow, Lykke, Jensen, Thomas Elbenhardt, Kleinert, Maximilian, Mouatt, J. R., Maarbjerg, S. J., Jeppesen, J. F., Prats Gavalda, Clara, Chiu, T. T., Boguslavsky, S., Klip, A., Schjerling, Peter & Richter, Erik A., 2013, In: Diabetes. 62, 4, p. 1139-1151 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle

    Sylow, Lykke, Jensen, Thomas Elbenhardt, Kleinert, Maximilian, Højlund, K., Kiens, Bente, Wojtaszewski, Jørgen F P, Prats Gavalda, Clara, Schjerling, P. & Richter, Erik A., 2013, In: Diabetes. 62, 6, p. 1865-1875 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Regulation of glycogen synthase in muscle and its role in Type 2 diabetes

    Kleinert, Maximilian, Sylow, Lykke & Richter, Erik A., 2013, In: Diabetes Management. p. 81-90 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  14. 2014
  15. Published

    Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

    Kleinert, Maximilian, Sylow, Lykke, Fazakerley, D. J., Krycer, J. R., Thomas, K. C., Oxbøll, A., Jordy, A. B., Jensen, Thomas Elbenhardt, Yang, G., Schjerling, P., Kiens, Bente, James, D. E., Ruegg, M. A. & Richter, Erik A., 2014, In: Molecular Metabolism. 3, 6, p. 630-641 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Akt and Rac1 signalling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

    Sylow, Lykke, Kleinert, Maximilian, Pehmøller, C., Prats Gavalda, Clara, Chiu, T. T., Klip, A., Richter, Erik A. & Jensen, Thomas Elbenhardt, 2014, In: Cellular Signalling. 26, 2, p. 323-331 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca2+ release

    Jensen, Thomas Elbenhardt, Sylow, Lykke, Rose, A. J., Madsen, A. L. B., Angin, Y., Maarbjerg, S. J. & Richter, Erik A., 2014, In: Molecular Metabolism. 3, 7, p. 742-753 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Is contraction-stimulated glucose transport feedforward regulated by Ca2+?

    Jensen, Thomas Elbenhardt, Angin, Y., Sylow, Lykke & Richter, Erik A., 2014, In: Experimental Physiology. 99, 12, p. 1562-1568 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Rac1- a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

    Sylow, Lykke, Møller, L. L. V., Kleinert, Maximilian, Richter, Erik A. & Jensen, Thomas Elbenhardt, 2014, In: Experimental Physiology. 99, 12, p. 1574-1580 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2015
  21. Published

    Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle

    D'Hulst, G., Sylow, Lykke, Hespel, P. & Deldicque, L., 2015, In: European Journal of Applied Physiology. 115, 6, p. 1219-1231 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

    Jensen, Thomas Elbenhardt, Ross, F. A., Kleinert, Maximilian, Sylow, Lykke, Knudsen, Jonas Roland, Gowans, G. J., Hardie, D. G. & Richter, Erik A., 2015, In: Biochemical Journal. 467, 3, p. 461-472 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Reply from Lykke Sylow, Lisbeth L. V. Møller, Maximilian Kleinert, Erik A. Richter and Thomas E. Jensen

    Sylow, Lykke, Møller, Lisbeth L V, Kleinert, Maximilian, Richter, Erik A. & Jensen, Thomas Elbenhardt, 2015, In: Journal of Physiology. 593, 9, p. 2239-2240 2 p.

    Research output: Contribution to journal › Comment/debate › Research

  24. Published

    Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1

    Sylow, Lykke, Møller, L. L. V., Kleinert, Maximilian, Richter, Erik A. & Jensen, Thomas Elbenhardt, 2015, In: Journal of Physiology. 593, 3, p. 645-656 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. 2016
  26. Published

    Decreased spontaneous activity in AMPK alpha 2 muscle specific kinase dead mice is not caused by changes in brain dopamine metabolism

    Møller, Lisbeth L V, Sylow, Lykke, Gøtzsche, C. R., Serup, A. K. L., Christiansen, S. H., Weikop, Pia, Kiens, Bente, Woldbye, David Paul Drucker & Richter, Erik A., 2016, In: Physiology & Behavior. 164, Part A, p. 300-305 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

    Sylow, Lykke, Laurent, I., Kleinert, Maximilian, Møller, Lisbeth L V, Ploug, Thorkil, Schjerling, Peter, Bilan, P. J., Klip, A., Jensen, Thomas Elbenhardt & Richter, Erik A., 2016, In: Journal of Physiology. 594, 17, p. 4997-5008 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Rac1 in muscle is dispensable for improved insulin action after exercise in mice

    Sylow, Lykke, Møller, Lisbeth L V, D'Hulst, G., Schjerling, P., Jensen, Thomas Elbenhardt & Richter, Erik A., 2016, In: Endocrinology. 157, 8, p. 3009-3015 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    The cancer drug Dasatinib increases PGC-1α in adipose tissue but has adverse effects on glucose tolerance in obese mice

    Sylow, Lykke, Long, J., Lokurkar, I. A., Zeng, X., Richter, Erik A. & Spiegelman, B. M., 2016, In: Endocrinology. 157, 11, p. 4184-4191 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells

    Sylow, Lykke, 2016, In: Laboratory Investigation. 96, 9, p. 1026 1 p.

    Research output: Contribution to journal › Comment/debate › Research

  31. Published

    mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

    Kleinert, Maximilian, Parker, B. L., Chaudhuri, R., Fazakerley, D. J., Serup, A. K. L., Thomas, K. C., Krycer, J. R., Sylow, Lykke, Fritzen, Andreas Mæchel, Hoffman, N. J., Jeppesen, J. F., Schjerling, P., Ruegg, M. A., Kiens, Bente, James, D. E. & Richter, Erik A., 2016, In: Molecular Metabolism. 5, 8, p. 646-655 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2017
  33. Published

    Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects

    Gliemann, Lasse, Rytter, N., Lindskrog, M., Slingsby, M. H. L., Åkerström, T., Sylow, Lykke, Richter, Erik A. & Hellsten, Ylva, 2017, In: Journal of Physiology. 595, 16, p. 5557-5571 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling

    Sjøberg, K. A., Frøsig, C., Kjøbsted, Rasmus, Sylow, Lykke, Kleinert, Maximilian, Betik, A. C., Shaw, C. S., Kiens, Bente, Wojtaszewski, Jørgen F P, Rattigan, S., Richter, Erik A. & McConell, G. K., 2017, In: Diabetes. 66, 6, p. 1501-1510 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Exercise-stimulated glucose uptake - regulation and implications for glycaemic control

    Sylow, Lykke, Kleinert, Maximilian, Richter, Erik A. & Jensen, Thomas Elbenhardt, 2017, In: Nature Reviews Endocrinology. 13, 3, p. 133-148 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  36. Published

    Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

    Kleinert, Maximilian, Parker, B. L., Fritzen, Andreas Mæchel, Knudsen, Jonas Roland, Jensen, Thomas Elbenhardt, Kjøbsted, Rasmus, Sylow, Lykke, Ruegg, M. A., James, D. E. & Richter, Erik A., 2017, In: Journal of Physiology. 595, 14, p. 4845-4855 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Rac1 and AMPK account for the majority of muscle glucose uptake stimulated by ex vivo contraction but not in vivo exercise

    Sylow, Lykke, Møller, Lisbeth L V, Kleinert, Maximilian, D'Hulst, G., De Groote, E., Schjerling, P., Steinberg, G. R., Jensen, Thomas Elbenhardt & Richter, Erik A., 2017, In: Diabetes. 66, 6, p. 1548-1559 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2018
  39. Published

    Differential effects of high-fat diet and exercise training on bone and energy metabolism

    Picke, A., Sylow, Lykke, Møller, Lisbeth L V, Kjøbsted, Rasmus, Schmidt, F. N., Steejn, M. W., Salbach-Hirsch, J., Hofbauer, C., Blüher, M., Saalbach, A., Busse, B., Rauner, M. & Hofbauer, L. C., 2018, In: Bone. 116, p. 120-134 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training

    Kleinert, Maximilian, Parker, B. L., Jensen, Thomas Elbenhardt, Raun, Steffen Henning, Pham, P., Han, X., James, D. E., Richter, Erik A. & Sylow, Lykke, 2018, In: Scientific Reports. 8, 11 p., 10723.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt

    Raun, Steffen Henning, Ali, Mona Sadek, Kjøbsted, Rasmus, Møller, Lisbeth L V, Federspiel, M. A., Richter, Erik A., Jensen, Thomas Elbenhardt & Sylow, Lykke, 2018, In: Journal of Physiology. 596, 12, p. 2283-2299 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    β-actin shows limited mobility and is only required for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle

    Madsen, A. L. B., Knudsen, Jonas Roland, Henriquez-Olguín, Carlos, Angin, Y., Zaal, K. J., Sylow, Lykke, Schjerling, P., Ralston, E. & Jensen, Thomas Elbenhardt, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 1, p. E110-E125 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 2019
  44. Published

    Current advances in our understanding of exercise as medicine in metabolic disease

    Sylow, Lykke & Richter, Erik A., 2019, In: Current Opinion in Physiology. 12, p. 12-19 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  45. Published

    Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

    Henriquez-Olguín, Carlos, Knudsen, Jonas Roland, Raun, Steffen Henning, Li, Z., Kellezi, Emilie Dalbram, Treebak, Jonas Thue, Sylow, Lykke, Holmdahl, R., Richter, Erik A., Jaimovich, E. & Jensen, Thomas Elbenhardt, 2019, In: Nature Communications. 10, 11 p., 4623.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

    Han, X., Møller, Lisbeth L V, De Groote, E., Bojsen-Møller, K. N., Davey, J., Henriquez-Olguín, Carlos, Li, Z., Knudsen, Jonas Roland, Jensen, Thomas Elbenhardt, Madsbad, Sten, Gregorevic, P., Richter, Erik A. & Sylow, Lykke, 2019, In: Journal of Cachexia, Sarcopenia and Muscle. 10, 6, p. 1241-1257 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry

    Nelson, M. E., Parker, B. L., Burchfield, J. G., Hoffman, N. J., Needham, E. J., Cooke, K. C., Naim, T., Sylow, Lykke, Ling, N. X. Y., Francis, D., Norris, D. M., Chaudhuri, R., Oakhill, J. S., Richter, Erik A., Lynch, G. S., Stöckli, J. & James, D. E., 2019, In: E M B O Journal. 38, 24, 20 p., e102578.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Rho GTPases-emerging regulators of glucose homeostasis and metabolic health

    Møller, Lisbeth L V, Klip, A. & Sylow, Lykke, 2019, In: Cells. 8, 5, 21 p., 434.

    Research output: Contribution to journal › Review › Research › peer-review

  49. 2020
  50. Published

    Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion

    Han, X., Raun, Steffen Henning, Carlsson, Michala, Sjøberg, K. A., Henriquez-Olguín, Carlos, Ali, Mona Sadek, Lundsgaard, Anne-Marie, Fritzen, Andreas Mæchel, Møller, Lisbeth L V, Li, Z., Li, J., Jensen, Thomas Elbenhardt, Kiens, Bente & Sylow, Lykke, 2020, In: Metabolism - Clinical and Experimental. 105, 14 p., 154169.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Circulating follistatin and activin A and their regulation by insulin in obesity and type 2 diabetes

    Sylow, Lykke, Vind, B. F., Kruse, R., Møller, P. M., Wojtaszewski, Jørgen F P, Richter, Erik A. & Højlund, K., 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 5, p. 1343-1354 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Housing temperature influences exercise training adaptations in mice

    Raun, Steffen Henning, Henriquez-Olguín, Carlos, Karavaeva, Iuliia, Ali, Mona Sadek, Møller, Lisbeth L V, Kot, Witold, Castro-Mejía, J. L., Nielsen, Dennis Sandris, Gerhart-Hines, Zach, Richter, Erik A. & Sylow, Lykke, 2020, In: Nature Communications. 11, 16 p., 1560.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)2, but not PAK1, in mouse skeletal muscle

    Møller, Lisbeth L V, Jaurji, M., Kjøbsted, Rasmus, Joseph, G. A., Madsen, A. B., Knudsen, Jonas Roland, Lundsgaard, Anne-Marie, Andersen, Nicoline Resen, Schjerling, P., Jensen, Thomas Elbenhardt, Krauss, R. S., Richter, Erik A. & Sylow, Lykke, 2020, In: Journal of Physiology. 598, 23, p. 5351-5377 27 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Integrin-associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients

    Draicchio, F., van Vliet, S., Ancu, O., Paluska, S. A., Wilund, K. R., Mickute, M., Sathyapalan, T., Renshaw, D., Watt, P., Sylow, Lykke, Burd, N. A. & Mackenzie, R., 2020, In: Journal of Physiology. 598, 24, p. 5701-5716 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Klyngevejledning til ph.d.- studerendes artikelskrivning

    Sylow, Lykke, 2020, Improving University Science Teaching and Learning - Pedagogical Projects 2020. Christiansen, F. V. & Arias, A. A. (eds.). Copenhagen: Department of Science Education, University of Copenhagen, p. 109-119 11 p. (Improving University Science Teaching and Learning - Pedagogical Projects, Vol. 15).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education › peer-review

  56. Published

    The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport

    Møller, Lisbeth L V, Nielsen, I. L., Knudsen, Jonas Roland, Andersen, Nicoline Resen, Jensen, Thomas Elbenhardt, Sylow, Lykke & Richter, Erik A., 2020, In: Physiological Reports. 8, 12, 13 p., e14460.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Conditioned media from MCF7 and BT474 breast cancer cells induce insulin resistance in skeletal muscle myotubes

    Ali, Mona Sadek, Han, X., Li, J., Jäättelä, M. & Sylow, Lykke, 28 Jan 2020, bioRxiv.

    Research output: Working paper › Preprint › Research

  58. 2021
  59. Published

    Editorial: Skeletal muscle immunometabolism

    Trollet, C., Cheng, A. J., Sylow, Lykke, Batista, M. L. & Pillon, N. J., 2021, In: Frontiers in Physiology. 12, 3 p., 683088.

    Research output: Contribution to journal › Editorial › Research

  60. Published

    Effect of hypoxic exercise on glucose tolerance in healthy and pre-diabetic adults

    De Groote, E., Britto, F. A., Balan, E., Warnier, G., Thissen, J., Nielens, H., Sylow, Lykke & Deldicque, L., 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, 1, p. E43-E54 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes

    Pham, Tang Cam Phung, Bojsen-Møller, K. N., Madsbad, Sten, Wojtaszewski, Jørgen F P, Richter, Erik A. & Sylow, Lykke, 2021, In: International Journal of Obesity. 45, p. 316-325 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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