Clare Louise Hawkins

Clare Louise Hawkins

Professor with special responsibilities


  1. 2019
  2. Published

    8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response. / Tang, Vickie; Fu, Shanlin; Rayner, Benjamin S.; Hawkins, Clare L.

    In: Redox Biology, Vol. 26, UNSP 101274, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation. / Macer-Wright, Jessica L.; Stanley, Naomi R.; Portman, Neil; Tan, Joanne T.; Bursill, Christina; Rayner, Benjamin S.; Hawkins, Clare L.

    In: Chemical Research in Toxicology, Vol. 32, No. 6, 2019, p. 1223-1234.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts. / Reyes, Leila; Hawkins, Clare L.; Rayner, Benjamin S.

    In: Nitric Oxide: Biology and Chemistry, Vol. 665, 2019, p. 132-142.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase. / Lim, Yean J.; Foo, Timothy C.; Yeung, Amanda W. S.; Tu, Xiaofan; Ma, Yuanqing; Hawkins, Clare L.; Witting, Paul K.; Jameson, Guy N. L.; Terentis, Andrew C.; Thomas, Shane R.

    In: Biochemistry, Vol. 58, No. 7, 2019, p. 974-986.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells. / Cai, Huan; Chuang, Christine Y.; Vanichkitrungruang, Siriluck; Hawkins, Clare L.; Davies, Michael J.

    In: Free Radical Biology and Medicine, Vol. 134, 2019, p. 526-536.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function. / Vanichkitrungruang, Siriluck; Chuang, Christine Y.; Hawkins, Clare L.; Hammer, Astrid; Hoefler, Gerald; Malle, Ernst; Davies, Michael J.

    In: Free Radical Biology and Medicine, Vol. 136, 2019, p. 118-134.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2018
  9. Published

    A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid. / Pan, Gary; Rayner, Benjamin; Zhang, Yunjia; van Reyk, David; Hawkins, Clare.

    In: Archives of Biochemistry and Biophysics, Vol. 642, 2018, p. 23-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart? / Hawkins, C. L.

    In: Acta Physiologica, Vol. 223, No. 4, e13106 , 2018.

    Research output: Contribution to journalEditorialResearchpeer-review

  11. Published

    Cellular responses to radical propagation from ion-implanted plasma polymer surfaces. / Stewart, Callum A. C.; Akhavan, Behnam; Santos, Miguel; Hung, JuiChien; Hawkins, Clare L.; Bao, Shisan; Wise, Steven G.; Bilek, Marcela M. M.

    In: Applied Surface Science, Vol. 456, 2018, p. 701-710.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Protein carbamylation : a key driver of vascular calcification during chronic kidney disease. / Hawkins, Clare L.

    In: Kidney International, Vol. 94, No. 1, 2018, p. 12-14.

    Research output: Contribution to journalComment/debateResearchpeer-review

  13. Published

    Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation. / Rayner, Benjamin S.; Zhang, Yunjia; Brown, Bronwyn E.; Reyes, Leila; Cogger, Victoria C.; Hawkins, Clare L.

    In: Free Radical Biology and Medicine, Vol. 129, 2018, p. 25-34.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The dys-regulation of anti-oxidant defense via an impairment of Nrf2 response in the pathology of Friedreich's ataxia : [Meeting Abstract]. / Chiang, Shannon; Anzovino, Amy; Brown, Bronwyn E.; Hawkins, Clare L.; Richardson, Des R.; Huang, Michael L. -H.

    In: Free Radical Biology and Medicine, Vol. 120, OP-19 , 2018, p. S35-S35.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  15. 2017
  16. Published

    Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia : An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis. / Anzovino, Amy; Chiang, Shannon; Brown, Bronwyn E; Hawkins, Clare L; Richardson, Des R; Huang, Michael L-H.

    In: American Journal of Pathology, Vol. 187, No. 12, 12.2017, p. 2858-2875.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis. / Ridiandries, Anisyah; Tan, Joanne T M; Ravindran, Dhanya; Williams, Helen; Medbury, Heather J; Lindsay, Laura; Hawkins, Clare; Prosser, Hamish C G; Bursill, Christina A.

    In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 31, No. 3, 03.2017, p. 1179-1192.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Catalytic oxidant scavenging by selenium-containing compounds : Reduction of selenoxides and N-chloramines by thiols and redox enzymes. / Carroll, Luke; Pattison, David I; Fu, Shanlin; Schiesser, Carl H; Davies, Michael J; Hawkins, Clare L.

    In: Redox Biology, Vol. 12, 2017, p. 872-882.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction. / Abdo, Adrian; Rayner, B.S.; van Reyk, D.M.; Hawkins, C.L.

    In: Redox Biology, Vol. 13, 2017, p. 623-632.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function. / Indo, Hiroko P.; Hawkins, Clare L; Nakanishi, Ikuo; Matsumoto, Ken-Ichiro; Matsui, Hirofumi; Suenaga, Shigeaki; Davies, Michael J; St Clair, Daret K; Ozawa, Toshihiko; Majima, Hideyuki J.

    Pharmacology of Mitochondria. Vol. 240 Springer, 2017. p. 439-456 (Handbook of Experimental Pharmacology, Vol. 240).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  21. 2016
  22. A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity. / Lok, Hiu Chuen; Sahni, Sumit; Jansson, Patric J; Kovacevic, Zaklina; Hawkins, Clare Louise; Richardson, Des R.

    In: The Journal of Biological Chemistry, Vol. 291, No. 53, 30.12.2016, p. 27042-27061.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space. / Indo, Hiroko P; Majima, Hideyuki J; Terada, Masahiro; Suenaga, Shigeaki; Tomita, Kazuo; Yamada, Shin; Higashibata, Akira; Ishioka, Noriaki; Kanekura, Takuro; Nonaka, Ikuya; Hawkins, Clare Louise; Davies, Michael J; Clair, Daret K St; Mukai, Chiaki.

    In: Scientific Reports, Vol. 6, 39015, 16.12.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions : implications for cataract development. / Tweeddale, Helen J; Hawkins, Clare Louise; Janmie, Joane F; Truscott, Roger J W; Davies, Michael J.

    In: Free Radical Research, Vol. 50, No. 10, 10.2016, p. 1116-1130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia. / Karimi Galougahi, Keyvan; Liu, Chia-Chi; Garcia, Alvaro; Gentile, Carmine; Fry, Natasha A; Hamilton, Elisha J; Hawkins, Clare L; Figtree, Gemma A.

    In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, Vol. 5, No. 2, e002824, 19.02.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages. / Love, D; Barrett, T.J.; White, M.Y.; Cordwell, S.J.; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Free Radical Biology & Medicine, Vol. 94, 2016, p. 88-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function : A Contributing Factor to Macrophage Dysfunction in Atherosclerosis? / Ismael, Fahd O; Barrett, Tessa J; Sheipouri, Diba; Brown, Bronwyn E; Davies, Michael J; Hawkins, Clare Louise.

    In: P L o S One, Vol. 11, No. 12, e0168844, 2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2015
  29. Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion. / Indo, Hiroko P.; Matsui, Hirofumi; Chen, Jing; Zhu, Haining; Hawkins, Clare Louise; Davies, Michael J.; Yarana, Chontida; Clair, Daret K St; Majima, Hideyuki J.

    In: Journal of Clinical Biochemistry and Nutrition, Vol. 57, No. 1, 01.07.2015, p. 13-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants : Second-order rate constants and implications for biological damage. / Carroll, Luke; Pattison, David I.; Fu, Shanlin; Schiesser, Carl H.; Davies, Michael J.; Hawkins, Clare Louise.

    In: Free Radical Biology & Medicine, Vol. 84, 07.2015, p. 279-288.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2014
  32. Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants. / Bonifay, Vincent; Barrett, Tessa J; Pattison, David I; Davies, Michael Jonathan; Hawkins, Clare Louise; Ashby, Michael T.

    In: Archives of Biochemistry and Biophysics, Vol. 564, 15.12.2014, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Role of cyanate in the induction of vascular dysfunction during uremia : more than protein carbamylation? / Hawkins, Clare L.

    In: Kidney International, Vol. 86, No. 5, 11.2014, p. 875-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. / Rayner, Benjamin S; Love, Dominic T; Hawkins, Clare L.

    In: Free Radical Biology & Medicine, Vol. 71, 06.2014, p. 240-55.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  35. Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides. / Kajer, Tracey B; Fairfull-Smith, Kathryn E; Yamasaki, Toshihide; Yamada, Ken-ichi; Fu, Shanlin; Bottle, Steven E; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 70, 05.2014, p. 96-105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Detection and characterisation of radicals in biological materials using EPR methodology. / Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: B B A - Reviews on Cancer, Vol. 1840, No. 2, 02.2014, p. 708-21.

    Research output: Contribution to journalReviewResearchpeer-review

  37. Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction. / Galougahi, Keyvan Karimi; Liu, Chia-Chi; Gentile, Carmine; Kok, Cindy; Nunez, Andrea; Garcia, Alvaro; Fry, Natasha A S; Davies, Michael Jonathan; Hawkins, Clare Louise; Rasmussen, Helge H; Figtree, Gemma A.

    In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, Vol. 3, No. 2, 2014, p. e000731.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. 2013
  39. Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. / Lloyd, Mitchell M; Grima, Michael A; Rayner, Benjamin S; Hadfield, Katrina A; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Free Radical Biology & Medicine, Vol. 65, 12.2013, p. 1352-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins : comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl). / Hadfield, Katrina A; Pattison, David I; Brown, Bronwyn E; Hou, Liming; Rye, Kerry-Anne; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Biochemical Journal, Vol. 449, No. 2, 15.01.2013, p. 531-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. 2012
  42. Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines. / Summers, Fiona A; Forsman Quigley, Anna; Hawkins, Clare L.

    In: Biochemical and Biophysical Research Communications, Vol. 425, No. 2, 24.08.2012, p. 157-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Reactions and reactivity of myeloperoxidase-derived oxidants : differential biological effects of hypochlorous and hypothiocyanous acids. / Pattison, David I; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Free Radical Research, Vol. 46, No. 8, 08.2012, p. 975-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. / Boon, Ai-Ching; Hawkins, Clare L; Bisht, Kavita; Coombes, Jeff S; Bakrania, Bhavisha; Wagner, Karl-Heinz; Bulmer, Andrew C.

    In: Free Radical Biology & Medicine, Vol. 52, No. 10, 15.05.2012, p. 2120-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Inactivation of thiol-dependent enzymes by hypothiocyanous acid : role of sulfenyl thiocyanate and sulfenic acid intermediates. / Barrett, Tessa J; Pattison, David I; Leonard, Stephen E; Carroll, Kate S; Davies, Michael Jonathan; Hawkins, Clare Louise.

    In: Free Radical Biology & Medicine, Vol. 52, No. 6, 15.03.2012, p. 1075-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Hypothiocyanous acid - benign or deadly? / Barrett, Tessa J; Hawkins, Clare L.

    In: Chemical Research in Toxicology, Vol. 25, No. 2, 20.02.2012, p. 263-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes. / Lok, Hiu Chuen; Suryo Rahmanto, Yohan; Hawkins, Clare L; Kalinowski, Danuta S; Morrow, Charles S; Townsend, Alan J; Ponka, Prem; Richardson, Des R.

    In: The Journal of Biological Chemistry, Vol. 287, No. 1, 02.01.2012, p. 607-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 2011
  49. High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase. / Morgan, Philip E; Pattison, David I; Talib, Jihan; Summers, Fiona A; Harmer, Jason A; Celermajer, David S; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 51, No. 9, 01.11.2011, p. 1815-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity. / Yu, Yu; Suryo Rahmanto, Yohan; Hawkins, Clare L; Richardson, Des R.

    In: Molecular Pharmacology, Vol. 79, No. 6, 06.2011, p. 921-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome. / Gracanin, Michelle; Lam, Magdalena A; Morgan, Philip E; Rodgers, Kenneth J; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 50, No. 2, 15.01.2011, p. 389-99.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2010
  53. Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts. / Rahmanto, Aldwin Suryo; Morgan, Philip E; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 49, No. 10, 30.11.2010, p. 1505-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation - an EPR study. / Jansson, Patric J; Hawkins, Clare L; Lovejoy, David B; Richardson, Des R.

    In: Journal of Inorganic Biochemistry, Vol. 104, No. 11, 11.2010, p. 1224-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. / Lane, Amanda E; Tan, Joanne T M; Hawkins, Clare Louise; Heather, Alison K; Davies, Michael Jonathan.

    In: Biochemical Journal, Vol. 430, No. 1, 15.08.2010, p. 161-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents. / Stanley, Naomi R; Pattison, David I; Hawkins, Clare L.

    In: Chemical Research in Toxicology, Vol. 23, No. 7, 19.07.2010, p. 1293-302.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. / Koelsch, Maud; Mallak, Roger; Graham, Garry G; Kajer, Tracey; Milligan, Marian K; Nguyen, Ly Q; Newsham, Dawn W; Keh, Jeremy S; Kettle, Anthony J; Scott, Kieran F; Ziegler, John B; Pattison, David I; Fu, Shanlin; Hawkins, Clare Louise; Rees, Martin D; Davies, Michael Jonathan.

    In: Biochemical Pharmacology, Vol. 79, No. 8, 15.04.2010, p. 1156-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Cellular effects of peptide and protein hydroperoxides. / Rahmanto, Aldwin Suryo; Morgan, Philip E; Hawkins, Clare Louise; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 48, No. 8, 15.04.2010, p. 1071-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. 2009
  60. The role of hypothiocyanous acid (HOSCN) in biological systems. / Hawkins, Clare L.

    In: Free Radical Research, Vol. 43, No. 12, 12.2009, p. 1147-58.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  61. Singlet-oxygen-mediated amino acid and protein oxidation : formation of tryptophan peroxides and decomposition products. / Gracanin, Michelle; Hawkins, Clare Louise; Pattison, David I; Davies, Michael Jonathan.

    In: Free Radical Biology & Medicine, Vol. 47, No. 1, 01.07.2009, p. 92-102.

    Research output: Contribution to journalJournal articleResearchpeer-review

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